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Troponin Rise After Emergency Orthopaedic-geriatric Surgery Randomised To Standard Care Versus Cardiology Care
Funder
National Health and Medical Research Council
Funding Amount
$87,193.00
Summary
This project will determine whether older patients who undergo emergency orthopaedic surgery who sustain cardiac injury (detected by means of a blood test called Troponin I) benefit from cardiology care as opposed to standard care. Troponin I is used to detect heart injury and can be elevated after surgery even if the patient is asymptomatic. Patients with a troponin elevation have a higher risk of death at 1 year. It is proposed that cardiology care and follow up might improve outcomes.
Safe Use Of Medicines Among The Elderly In The Community Who Receive Partial Supported Care Services
Funder
National Health and Medical Research Council
Funding Amount
$83,223.00
Summary
People living in supported residential services and retirement villages are frail elderly with minimal social support. Data on medicine use by people who receive intermediate care support are limited. The proposed study will investigate medicine use and related problems in this group of elderly. Strategies for optimizing medicine use and health outcomes will be identified in consultation with stakeholders. The efficacy of a preferred and feasible strategy will also be tested.
A Comparison Of Loaded And Unloaded Exercise For People With Non-specific Chronic Low Back Pain (NSCLBP)
Funder
National Health and Medical Research Council
Funding Amount
$42,410.00
Summary
Chronic low back pain is a common and costly condition. This research will conduct studies to determine the important ingredients of exercise programs that are related to successful outcomes for people with chronic low back pain (CLBP) and also to determine the effects of an exercise program intended to strengthen or load the low back muscles and a program that encourages movement restoration through movement not intended to strengthen for people with non-specific CLBP.
Signalling And Transcriptional Activity For Craniofacial Morphogenesis In An Experimental Genetic Mouse Model
Funder
National Health and Medical Research Council
Funding Amount
$74,755.00
Summary
Abnormalities in craniofacial development affect 2-1000 births in Australia. The aim of this project is to identify genes crucial for the development of the head and face. In particular the project focuses on the Twist1 gene. TWIST1 plays a key role in craniofacial development and individuals lacking functional Twist1display facial anomalies such as craniosynostosis and cleft palate. Dissecting the function of Twist1 is essential to identifying new avenues for the prevention of these defects.
Viral Reservoirs:Role Of Naive T-cells In The Pathogeneisis Of T-cell Decline And Longterm Persistence Of HIV Infection.
Funder
National Health and Medical Research Council
Funding Amount
$85,716.00
Summary
Despite dramatic advances in treatment for HIV infection, HIV cannot be cured. The main reason why cure is not possible is because HIV can persist in long lived cells and these infected cells are not recognised by the immune system. This project will examine the role of a particular type of infection fighting cell, the naive T-cell, in long term persistence of HIV. The project will determine how naive T-cells are infected with HIV and what happens to these cells following HIV treatment.