Genomic Analysis Of DNA Binding And Gene Regulation By The Chromatin Remodelling Factor UBF
Funder
National Health and Medical Research Council
Funding Amount
$624,254.00
Summary
Synthesis of ribosomes, the cellular protein synthetic machinery, is the major anabolic event of a growing cell and is frequently dysregulated during disease such as cancer. This grant will examine a protein termed UBF that we think plays an important role in orchestrating the cellular response to dysregulated ribosome biogenesis. By understanding how UBF functions we hope to uncover novel therapeutic approaches to treat diseases associated with ribosome stress .
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Improving access to phylogenomic resources for under-resourced species: a new look at existing tools. This project will have an impact on our understanding of how to most effectively use existing genomic resources to benefit a wider range of species and to better design new genomic resources. By doing so, improved access to genomic resources will be provided to species that currently have few options.
Genomic signatures of adaptive diversification in woodland Eucalyptus. This project aims to map the sources of adaptive alleles underlying diversification is to reveal insights into the mechanisms of speciation. The source of the raw material for evolution can have significant impacts on the speed with which populations can adapt. An emerging pattern in speciation research is the importance of ancient alleles and introgressed genes, which differ in the genomic signatures left by selection. Eucal ....Genomic signatures of adaptive diversification in woodland Eucalyptus. This project aims to map the sources of adaptive alleles underlying diversification is to reveal insights into the mechanisms of speciation. The source of the raw material for evolution can have significant impacts on the speed with which populations can adapt. An emerging pattern in speciation research is the importance of ancient alleles and introgressed genes, which differ in the genomic signatures left by selection. Eucalyptus offers a unique opportunity to explore these modes of evolution using the latest genomic tools. Improving our understanding of adaptation and genetic variation in woodland eucalypts is expected to make a significant contribution to their conservation, management and restoration.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100002
Funder
Australian Research Council
Funding Amount
$1,040,000.00
Summary
Distributed Memory Cluster for the Intersect consortium of universities. Distributed memory cluster:
This project aims to establish a new supercomputing facility. The NSW research community has used high performance computing (HPC) to achieve major breakthroughs across a diverse range of disciplines including astrophysics, bioinformatics, environmental science, information technology and engineering. As the use of HPC increases, the application-specific needs of the research community become mo ....Distributed Memory Cluster for the Intersect consortium of universities. Distributed memory cluster:
This project aims to establish a new supercomputing facility. The NSW research community has used high performance computing (HPC) to achieve major breakthroughs across a diverse range of disciplines including astrophysics, bioinformatics, environmental science, information technology and engineering. As the use of HPC increases, the application-specific needs of the research community become more diverse, requiring greater flexibility as well as higher performance. The present facility is no longer internationally competitive, and is hampering progress in cutting edge research. The new cluster is designed to provide a greater than 10-fold increase in computing capability.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100032
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
Access to the National Computing Infrastructure peak supercomputing facility. This project aims to continue the access of Intersect’s computational researchers to the National Computational Infrastructure (NCI) peak supercomputing facility. The peak supercomputing facility at NCI is critical collaborative infrastructure on a globally competitive scale. Transformative advances in science and technology increasingly rely on high performance computing capabilities across a wide range of research di ....Access to the National Computing Infrastructure peak supercomputing facility. This project aims to continue the access of Intersect’s computational researchers to the National Computational Infrastructure (NCI) peak supercomputing facility. The peak supercomputing facility at NCI is critical collaborative infrastructure on a globally competitive scale. Transformative advances in science and technology increasingly rely on high performance computing capabilities across a wide range of research disciplines. Ongoing access to this facility will allow researchers to tackle major problems in national priority areas including energy, health, and environmental change.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100143
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Flexible architecture high-performance computing facility for the intersect consortium of New South Wales. This new supercomputing facility is an important addition to the nation's research infrastructure and will enable world-leading, New South Wales researchers to continue their ground breaking work in increasingly competitive environments. Much of the research to be undertaken at the facility lies in areas of national priority, including frontier technologies and environmental sustainability.
The endangered swift parrot as a model for managing small migratory birds. Endangered swift parrots use variable locations while breeding in eastern Tasmania and over winter on the Australian mainland. This project aims to develop effective conservation strategies for swift parrots and other migrants using new and long term data and innovative technological solutions to tracking small birds across vast landscapes.
Processing mathematics tasks: the nature and role of visual and non-visual reasoning in digital and non-digital environments. Within the next four years, it is likely that the National Assessment Plan for Literacy and Numeracy (NAPLAN) will be administered in a digital mode. This project identifies differences between the delivery of mathematics assessment in pencil-and-paper and computer-based modes. Primary students' mathematics reasoning is compared across these modes and to cohorts from Sing ....Processing mathematics tasks: the nature and role of visual and non-visual reasoning in digital and non-digital environments. Within the next four years, it is likely that the National Assessment Plan for Literacy and Numeracy (NAPLAN) will be administered in a digital mode. This project identifies differences between the delivery of mathematics assessment in pencil-and-paper and computer-based modes. Primary students' mathematics reasoning is compared across these modes and to cohorts from Singapore.Read moreRead less
Social and geographical location and its impact on mathematics teaching and learning. Too many students from poor urban backgrounds or from rural communities are at risk of underperforming in school mathematics. This project identifies the critical factors that contribute to this failure and seeks to develop improved practices to enable greater access to school mathematics.