Commensal benefits: genomic basis for suppressing plant pathogens with Pseudomonas biocontrol species. Food security is an issue of mounting significance due to unpredictable climate trends and increasing global population growth. A feature of paramount importance to reliable crop production is the capacity to control plant diseases. This project investigates natural plant colonising bacteria as a tool for protecting plants from disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100016
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Synthetic Biology: from Genomics to Valuable Bioproducts. Genomics has led to the discovery of both the fine and gross characteristics of specific microbial physiologies. This project aims to take the genetic diversity inherent in microbial systems and exploit it for biotechnology applications, using the cutting-edge facilities available for synthetic biology. The acquisition of a long-read sequencing platform, droplet digital PCR machine, pulsed-field electrophoresis apparatus, DNA library syst ....Synthetic Biology: from Genomics to Valuable Bioproducts. Genomics has led to the discovery of both the fine and gross characteristics of specific microbial physiologies. This project aims to take the genetic diversity inherent in microbial systems and exploit it for biotechnology applications, using the cutting-edge facilities available for synthetic biology. The acquisition of a long-read sequencing platform, droplet digital PCR machine, pulsed-field electrophoresis apparatus, DNA library system and small scale bioreactor will address the limitations of short-read sequencing, large fragment cloning and gene expression technologies, currently creating bottlenecks for synthetic biologists.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100204
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
A systems biology capability for the Ramaciotti Centre for Genomics. A systems biology capability for the Ramaciotti Centre for Genomics:
The project aims to introduce a complete systems biology capability to the Ramaciotti Centre for Genomics. This is intended to provide a complete systems biology workflow, including improved data analysis for next-generation sequencing, tissue preparation and imaging, and mass spectrometry for proteomics and metabolomics. This would enable a truly systems app ....A systems biology capability for the Ramaciotti Centre for Genomics. A systems biology capability for the Ramaciotti Centre for Genomics:
The project aims to introduce a complete systems biology capability to the Ramaciotti Centre for Genomics. This is intended to provide a complete systems biology workflow, including improved data analysis for next-generation sequencing, tissue preparation and imaging, and mass spectrometry for proteomics and metabolomics. This would enable a truly systems approach to biological problems, supporting researchers and projects that focus on microbial and mammalian metabolism, carbohydrate chemistry and synthetic biology. Read moreRead less
Decoding miRNA regulated genetic circuits. This project will aim to develop a much better understanding of how the process of making proteins from genes is regulated, and will develop scientific software capable of predicting how a cell will respond to changes in this regulation. The results will have widespread use, including assistance in deciding the best treatments for genetic diseases.
Advancing programmable genetic computation to control plant gene activity. Plants can sense diverse internal and external conditions and integrate them to appropriately tune their response and maximize fitness. Plant biotechnology relies heavily on manipulating gene activity to change cell functions and confer advantageous agronomic traits. However, our ability to control plant gene activity remains rudimentary, limiting our biotechnology capabilities. This project aims to develop synthetic gene ....Advancing programmable genetic computation to control plant gene activity. Plants can sense diverse internal and external conditions and integrate them to appropriately tune their response and maximize fitness. Plant biotechnology relies heavily on manipulating gene activity to change cell functions and confer advantageous agronomic traits. However, our ability to control plant gene activity remains rudimentary, limiting our biotechnology capabilities. This project aims to develop synthetic gene logic gates in plants, to enable the construction of programmable genetically-encoded computational functions that can sense and process customizable inputs to drive desired changes in plant function. This advance will underpin useful applications in plant biotechnology such as improved crop stress tolerance and yield.Read moreRead less
The discovery and characterisation of novel protein regulators of blood cell formation. All of the mature blood cells in the human body are derived from a common ancestor cell type known as a stem cell. Our proposed studies will enhance our knowledge of how functional, mature blood cells are formed from stem cells and how dysregulation of these normally tightly controlled pathways can give rise to severe blood diseases.