Defining how signalling pathways cooperate to regulate organ size. Control of organ size is essential for organ function and organism viability, and varies greatly across the animal kingdom. This project aims to understand how three important signalling pathways co-ordinately regulate organ size during development and also limit aberrant growth. By applying genomics, genetics and bioinformatics techniques, this project aims to discover a core set of growth genes that are regulated by different s ....Defining how signalling pathways cooperate to regulate organ size. Control of organ size is essential for organ function and organism viability, and varies greatly across the animal kingdom. This project aims to understand how three important signalling pathways co-ordinately regulate organ size during development and also limit aberrant growth. By applying genomics, genetics and bioinformatics techniques, this project aims to discover a core set of growth genes that are regulated by different signalling pathways and the mechanism by which transcription of these genes is repressed in order to eliminate faulty cells. Intended benefits are creation of jobs, new knowledge on fundamental principles of life and the stimulation of new research into organ size control.Read moreRead less
Advancing plant synthetic gene circuit capability, robustness, and use. This project aims to advance our ability to control gene expression in plants using synthetic gene circuits. By expanding the toolkit and optimizing circuit components, we aim to achieve more complex capabilities and robust implementation. Furthermore, we will apply gene circuit technologies to enhance plant frost tolerance. The expected project outcomes include a significant advance in gene circuit capabilities, a better un ....Advancing plant synthetic gene circuit capability, robustness, and use. This project aims to advance our ability to control gene expression in plants using synthetic gene circuits. By expanding the toolkit and optimizing circuit components, we aim to achieve more complex capabilities and robust implementation. Furthermore, we will apply gene circuit technologies to enhance plant frost tolerance. The expected project outcomes include a significant advance in gene circuit capabilities, a better understanding of their behavior in plant cells, and the ability to use them to confer advantageous traits. The benefits of this research include new plant biotechnology tools that will underpin future crop yield improvements, and advances in plant-based pharmaceuticals and materials.Read moreRead less
What drives the Anterior Expansion of the Central Nervous System? A striking and highly conserved feature of the central nervous system is that the brain is larger than the spinal cord. Despite the manifest implications this has for nervous system function, the underlying drivers are largely unknown. This project aims to investigate the mechanisms controlling anterior expansion of the central nervous system, and will generate new knowledge in the areas of nervous system development and evolution ....What drives the Anterior Expansion of the Central Nervous System? A striking and highly conserved feature of the central nervous system is that the brain is larger than the spinal cord. Despite the manifest implications this has for nervous system function, the underlying drivers are largely unknown. This project aims to investigate the mechanisms controlling anterior expansion of the central nervous system, and will generate new knowledge in the areas of nervous system development and evolution. This project aims to impact on our understanding of nervous system function, develop bioinformatics tools with broad utility within the biosciences field, strengthen Australia’s international standing in the developmental neuroscience, and enhance the capacity for interdisciplinary international collaborations.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100103
Funder
Australian Research Council
Funding Amount
$476,833.00
Summary
Improving efficacy of biopesticides through understanding mode of action. Insecticides are used extensively to control agricultural pests, but options are increasingly limited owing to environmental and human health concerns. A biopesticide, Bt, provides a valuable ‘soft’ option for control of caterpillars that are amongst the world's most damaging insect pests. However, little is known about how ingested Bt kills insects and this knowledge gap constrains options to improve efficacy and to count ....Improving efficacy of biopesticides through understanding mode of action. Insecticides are used extensively to control agricultural pests, but options are increasingly limited owing to environmental and human health concerns. A biopesticide, Bt, provides a valuable ‘soft’ option for control of caterpillars that are amongst the world's most damaging insect pests. However, little is known about how ingested Bt kills insects and this knowledge gap constrains options to improve efficacy and to counter resistance. This project connects industry end users (Cotton RDC; Bayer CropScience) with research training (Macquarie University) and applied research (CSIRO) to model how Bt interacts with the insect gut. This model will make valuable contributions to ensuring sustained and improved efficacy of Bt biopesticides.Read moreRead less