Cellular Gene Regulation Networks. The benefit to Australia will be scientific in terms of providing an understanding of how cells integrate transcriptional control systems and the networks that are involved. This will inform research on folate deficiency and aberrant human development and towards identifying genes that are important in improving efficiency of microbial fermentations. Additional and more practical major benefits will follow from the development of tools to analyse interaction ....Cellular Gene Regulation Networks. The benefit to Australia will be scientific in terms of providing an understanding of how cells integrate transcriptional control systems and the networks that are involved. This will inform research on folate deficiency and aberrant human development and towards identifying genes that are important in improving efficiency of microbial fermentations. Additional and more practical major benefits will follow from the development of tools to analyse interactions between control systems, including software of value to the research community. The work will provide postgraduate students with major training in up-to-date genomic technologies, and in the interface between application of bioinformatics and experimental science.
Read moreRead less
Next-generation epigenetic analysis: direct reading of DNA methylation. This project aims to develop a new molecular tool to directly and dynamically read chemical modifications on genomic DNA (epigenetics) by utilizing advanced nanomaterials with the unique features of Raman spectroscopy. Epigenetics affects cellular processes and controls genetic programs by turning them “on” and “off" but there is currently no direct method to measure modifications on DNA. A new technology will be designed to ....Next-generation epigenetic analysis: direct reading of DNA methylation. This project aims to develop a new molecular tool to directly and dynamically read chemical modifications on genomic DNA (epigenetics) by utilizing advanced nanomaterials with the unique features of Raman spectroscopy. Epigenetics affects cellular processes and controls genetic programs by turning them “on” and “off" but there is currently no direct method to measure modifications on DNA. A new technology will be designed to avoid complicated procedures/chemistry for DNA epigenetic analysis providing a specific molecular fingerprint. The anticipated outcomes include a new technique and advanced knowledge in nanomaterials and DNA functions, thus strengthening the economic viability of Australian manufacturing and biotechnology sectors.Read moreRead less
How do cells regulate the synthesis and localisation of coenzyme Q? The aims of this project are to identify how cells regulate the synthesis and the distribution of coenzyme Q between different organelles, and how these processes are affected when cells experience various conditions of stress. Coenzyme Q is a fat-soluble molecule present in all cell membranes and essential for normal cell function. Despite this, relatively little is known about the systems that regulate the synthesis and cellul ....How do cells regulate the synthesis and localisation of coenzyme Q? The aims of this project are to identify how cells regulate the synthesis and the distribution of coenzyme Q between different organelles, and how these processes are affected when cells experience various conditions of stress. Coenzyme Q is a fat-soluble molecule present in all cell membranes and essential for normal cell function. Despite this, relatively little is known about the systems that regulate the synthesis and cellular location of coenzyme Q. The project plans to identify the genes and proteins required for coenzyme Q regulation of sub-cellular distribution in unstressed and stressed cells. In doing so, the project could provide a greater understanding of the ways cells maintain normal coenzyme Q levels and respond to stress.Read moreRead less