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Tracing the origins of stress in the symbionts of reef-building corals. Symbiotic dinoflagellates of corals are critical to the world's major tropical reef ecosystems. Recent work in our laboratories and others has revealed that these algae are sensitive to a wide array of stresses (including climate change) and hence may be the ?Achilles Heel? of reef ecosystems. This project will identify the key genes and processes in these algae using expressed sequence tags and microarray technology. On th ....Tracing the origins of stress in the symbionts of reef-building corals. Symbiotic dinoflagellates of corals are critical to the world's major tropical reef ecosystems. Recent work in our laboratories and others has revealed that these algae are sensitive to a wide array of stresses (including climate change) and hence may be the ?Achilles Heel? of reef ecosystems. This project will identify the key genes and processes in these algae using expressed sequence tags and microarray technology. On this basis, the underlying molecular mechanisms of these stress responses and their genetic diversity will be studied in order to better understand the differential susceptibility of reef-building corals to bleaching.Read moreRead less
The genomic programming of complex organisms. The project will have far-reaching consequences in medicine, agriculture, biotechnology, engineering, information science and associated industries. It will provide a platform for the rationalization of genetic epidemiology and genetic improvement programs, the development of a wide range of new diagnostics and therapies, the development of new core technologies and practical approaches in genetics and genetic diversity, a framework for advanced gen ....The genomic programming of complex organisms. The project will have far-reaching consequences in medicine, agriculture, biotechnology, engineering, information science and associated industries. It will provide a platform for the rationalization of genetic epidemiology and genetic improvement programs, the development of a wide range of new diagnostics and therapies, the development of new core technologies and practical approaches in genetics and genetic diversity, a framework for advanced genetic engineering, the development of new principles and systems for information storage and transmission, and the design of artificial systems capable of self-referential assembly in other environments.Read moreRead less
Organisation, expression and diversity of the sub-telomeric regions of the ancient eukaryote, Giardia duodenalis. We propose to extend our findings on the extreme plasticity of the structure and organisation of the sub-telomeric region of the complete genome of Giardia by more extensive chromosome walking, and comparison of different isolates. These regions are subject to gene conversion, transcriptional silencing, gene mobility, recombination, variable surface protein expression, subtelomeric i ....Organisation, expression and diversity of the sub-telomeric regions of the ancient eukaryote, Giardia duodenalis. We propose to extend our findings on the extreme plasticity of the structure and organisation of the sub-telomeric region of the complete genome of Giardia by more extensive chromosome walking, and comparison of different isolates. These regions are subject to gene conversion, transcriptional silencing, gene mobility, recombination, variable surface protein expression, subtelomeric instability and the insertion of transposable elements, a dynamic balance between structural conservation and rapid evolution. This is a rare opportunity to understand the forces at work in moulding eukaryotic sub-telomeric sequences because Giardia is not constrained by sexual homogenisation and the dynamic variability is retained.Read moreRead less
Mechanosensitive properties and modulation of N-methyl-D-aspartate (NMDA) receptors by lipid environment. This project will provide new information about the molecular determinants which influence NMDA receptor channel gating that will significantly advance our understanding of a link between NMDA receptor function and many neurodegenerative diseases as well as pain and learning and memory. The outcomes of this project may lead to the discovery of novel lipid-based biomaterials for application i ....Mechanosensitive properties and modulation of N-methyl-D-aspartate (NMDA) receptors by lipid environment. This project will provide new information about the molecular determinants which influence NMDA receptor channel gating that will significantly advance our understanding of a link between NMDA receptor function and many neurodegenerative diseases as well as pain and learning and memory. The outcomes of this project may lead to the discovery of novel lipid-based biomaterials for application in medicine and the drug industry. This research is highly significant in relation to human health. The biological and nutritional aspects of polyunsaturated lipids and dietary fish oils have long been recognized. Thus this project will provide further knowledge that could benefit the health of the nation with consequent reduced health care costs.Read moreRead less
Descartes' Ontology of Everyday Life. Australia has a strong international reputation in philosophy and the history of philosophy. This project will contribute to our standing in the international community of scholars and to the teaching of Australian students in the historical origins of contemporary ideas and problems. It will furthermore contribute to the growing recognition of early modern interdisciplinary studies within Australia by drawing on ideas from the history of science, early mode ....Descartes' Ontology of Everyday Life. Australia has a strong international reputation in philosophy and the history of philosophy. This project will contribute to our standing in the international community of scholars and to the teaching of Australian students in the historical origins of contemporary ideas and problems. It will furthermore contribute to the growing recognition of early modern interdisciplinary studies within Australia by drawing on ideas from the history of science, early modern philosophy, medieval philosophy and the history of early modern thought and ideas.Read moreRead less
The Baroque in Architectural Culture, 1880-1980. This project will show the significance of historical architecture in the present day, and lead to better understanding of the cultural role of building. It will enhance the reputation of Australian research on the architectural history of early modern Europe, and on issues of historical method. It will train emerging researchers and develop a research environment for further research on this field. The project will foster international connection ....The Baroque in Architectural Culture, 1880-1980. This project will show the significance of historical architecture in the present day, and lead to better understanding of the cultural role of building. It will enhance the reputation of Australian research on the architectural history of early modern Europe, and on issues of historical method. It will train emerging researchers and develop a research environment for further research on this field. The project will foster international connections and collaborations and support the publication of internationally relevant research.Read moreRead less
Science and Religion in Early Modern Europe. This project seeks to elucidate the nature of early modern science, early modern religion, and their relationship. A major focus will be the shift from medieval conceptions of science (scientia) and religion (religio) as inner virtues, to the modern understanding of science and religion as bodies of knowledge and sets of practices. This transformation was fundamental to the emergence of modern science and made possible a new kind of relationship be ....Science and Religion in Early Modern Europe. This project seeks to elucidate the nature of early modern science, early modern religion, and their relationship. A major focus will be the shift from medieval conceptions of science (scientia) and religion (religio) as inner virtues, to the modern understanding of science and religion as bodies of knowledge and sets of practices. This transformation was fundamental to the emergence of modern science and made possible a new kind of relationship between science and religion?one unique to the West. The project will enhance our understanding of the rise of science and identify distinctive features of modern Western culture.Read moreRead less
A unified theory of the individual - a central problem in analytical philosophy. This project will further increase Australia's already high profile in analytic philosophy. This will foster an intellectual environment within Australia that will attract highly skilled overseas academics who bring knowledge and funding to Australia, benefiting both Australian researchers and students. This will in turn attract overseas fee-paying students who bring economic and cultural benefits to Australia.
The logical and metaphysical challenge of vague language. Where do we draw the line between life and death, tall and short, right and wrong? The vagueness or indeterminacy of such concepts prohibits easy answers. This projects aims to provide a philosophical analysis of such concepts which abound in natural language with a view to showing that orthodox views in logic and metaphysics are challenged by their presence. This analysis is to be published as a monograph whose significance lies in the f ....The logical and metaphysical challenge of vague language. Where do we draw the line between life and death, tall and short, right and wrong? The vagueness or indeterminacy of such concepts prohibits easy answers. This projects aims to provide a philosophical analysis of such concepts which abound in natural language with a view to showing that orthodox views in logic and metaphysics are challenged by their presence. This analysis is to be published as a monograph whose significance lies in the fact that it provides one of only four book-length treatments of the matter and does so from an entirely novel perspective.Read moreRead less
Particle Transport and Separation in High Aspect Ratio Inclined Channels. This project will be of benefit to the Australian coal and mineral processing industries, worth tens of billions of dollars to the Australian economy each year. The objective is to establish new options for the processing of particles as large as 50mm, and smaller than 50 microns in size, and hence significantly extend the operating size range of the Reflux Classifier. The development of new resources, especially those of ....Particle Transport and Separation in High Aspect Ratio Inclined Channels. This project will be of benefit to the Australian coal and mineral processing industries, worth tens of billions of dollars to the Australian economy each year. The objective is to establish new options for the processing of particles as large as 50mm, and smaller than 50 microns in size, and hence significantly extend the operating size range of the Reflux Classifier. The development of new resources, especially those of poorer grade, requires more effective separation technology. Success in this project will significantly benefit the end users of the technology and also contribute to Australia's Mining Services industry.Read moreRead less