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Women's Hormones And Health Across The Adult Life Span
Funder
National Health and Medical Research Council
Funding Amount
$951,005.00
Summary
Sex hormones are important in younger and older women’s health. However, normal levels of sex hormones for women of different ages and the extent to which sex hormones are associated with common health outcomes are yet to be established. These issues will be systematically studied in comprehensive, community-based studies of younger and older Australian women. The findings will be immediately translated into clinical practice guidelines and community education.
Molecular Genetic Risk Factors And Mechanisms In Blinding Eye Disease
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This project aims to understand the genetic causes of blinding eye diseases. We have recently identified genetic variation that contributes to the risk of glaucoma and diabetic eye disease. We are exploring the mechanisms through which this leads to disease by looking at differences in the genes in patients with disease compared to unaffected individuals. We hope to be able to identify genes that could be the target of new therapies to prevent blindness and visual impairment in the community.
Discovery And Translation Of Disease Causing Mutations With Genomic And Transcriptomic Data
Funder
National Health and Medical Research Council
Funding Amount
$622,655.00
Summary
This proposal will develop and apply methods for the analysis of genetic data generated from family and cohort studies of collaborators to identify genetic risk loci for both neurogenetic disorders and infectious diseases, particularly malaria. The project will combine large-scale datasets of different types and across different species. This will require the development and application of multivariate statistical analysis methods suited to the data.
Translation Of Genetic, Genomic And Transcriptomic Discoveries Into Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$638,517.00
Summary
This project will progress studies on genes affecting common diseases to clinical application. Specifically, I aim to (1) establish the basis for the association of the identified MS risk factors with MS susceptibility; (2) establish if the three MS blood immune types we have identified, which are tagged by MS susceptibility genes, and altered by MS therapy, predict clinical response to therapy; and (3) determine the effect of host genetic variation in response to therapy for HCV, HIV and flu.
Decoding Mechanisms Of Brain-intestinal Communication
Funder
National Health and Medical Research Council
Funding Amount
$640,210.00
Summary
Obesity is a worldwide concern to human health. Research into how fat is regulated in the body may provide new therapeutic options. It is not well understood how signals from the brain control fat storage. We have recently identified a gene that is important for the communication between the brain and the intestine in the control of fat levels. As such, our work will enable us to better understand this phenomenon.
Using cutting edge sequencing and genotyping technology, genes causing common and rare human diseases will be identified, and genetic methods developed to diagnose genetic diseases in both antenatal and postnatal life. Treatments for common rheumatic diseases affecting tens of thousands of Australians will be developed informed by these genetic findings.
Clinical Application Of Genomic Approaches For Cancer
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
Cancer is the cause of 1 in 8 deaths worldwide. Cancer occurs due to errors or mutations in the DNA of normal cells. I will identify the mutations in tumour cells, which will tell us: i) How the tumour started and grew ii) How to treat the tumour and kill the cancer The work involves a variety of cancer types including mesothelioma, melanoma, oesophageal and breast cancer. The overall aim is to apply some of the research findings or approaches into patient care to improve patient survival.
A/Prof Thomas' Senior Research Fellowship will provide support for the continued development of a broad-based, national and international research program focused on the biology and clinical aspects of connective tissue tumours. A/Prof Thomas' career goals are to continue work in basic, translational and clinical research into these tumours which include osteosarcoma, liposarcoma, giant cell tumour of bone and the inherited risk of development of these neoplasms.
The Fellowship would support Professor Bowtell, one of the world’s leading ovarian cancer researchers. His work focuses on clinical problems of chemotherapy resistance and the development of new therapeutic approaches. His studies are underpinned by the Australian Ovarian Cancer Study (AOCS), one of the world’s most sophisticated clinical cohort studies of ovarian cancer, with over 3000 Australian women enrolled.
Using Genomics To Understand Psychiatric Disorders
Funder
National Health and Medical Research Council
Funding Amount
$772,490.00
Summary
The last five years have seen unprecedented discovery of DNA risk factors for psychiatric disorders. In my Fellowship I will combine analyses of genomic data with development of new statistical methodologies to contribute to my vision that application of genomics methods in psychiatry will continue to catalyze more discoveries of the causes of these complex genetic disorders.