Improving the analysis of trace DNA samples in forensic science and human identification. The introduction of DNA technology into forensic science has revolutionised this profession, by generating a very high level of individual discrimination through genetic profiling. However, there are still many crime scenes from which it is proving difficult to obtain sufficient DNA sample for such powerful profiling. This project will develop modifications to current techniques and procedures, as well as ....Improving the analysis of trace DNA samples in forensic science and human identification. The introduction of DNA technology into forensic science has revolutionised this profession, by generating a very high level of individual discrimination through genetic profiling. However, there are still many crime scenes from which it is proving difficult to obtain sufficient DNA sample for such powerful profiling. This project will develop modifications to current techniques and procedures, as well as new novel approaches, to improve the targeting, collection, extraction and typing of trace amounts of biological samples. These results will significantly improve our ability to fight crime, especially high volume crime, act as a deterrent, and assist in disaster victim identification.Read moreRead less
Unlocking the genetic and biochemical potential of kangaroo paws. Using cutting-edge gene technology and an interdisciplinary approach, this project aims to uncover the genes responsible for flower colour in the iconic kangaroo paws of Western Australia, and identify the compounds that produce the colours. The project expects to produce the first entire kangaroo paw genome and identify unique genetic variants and biochemicals underlying colour differences. This new knowledge should help horticul ....Unlocking the genetic and biochemical potential of kangaroo paws. Using cutting-edge gene technology and an interdisciplinary approach, this project aims to uncover the genes responsible for flower colour in the iconic kangaroo paws of Western Australia, and identify the compounds that produce the colours. The project expects to produce the first entire kangaroo paw genome and identify unique genetic variants and biochemicals underlying colour differences. This new knowledge should help horticultural programs to more easily breed varieties with desirable and highly marketable new colours, and could assist in conserving these amazing Australian plants.Read moreRead less
Silent witness: New analytical approaches to advance and enhance the forensic value of human hair. The Australian criminal justice system is under ever-increasing scrutiny with recent threats to national security. Courtroom evidence is expected to carry an objective indication of its value, largely as a result of the success and widespread application of DNA evidence. This is problematic for conventional human hair evidence which has traditionally been presented as the expert opinion of a hair e ....Silent witness: New analytical approaches to advance and enhance the forensic value of human hair. The Australian criminal justice system is under ever-increasing scrutiny with recent threats to national security. Courtroom evidence is expected to carry an objective indication of its value, largely as a result of the success and widespread application of DNA evidence. This is problematic for conventional human hair evidence which has traditionally been presented as the expert opinion of a hair examiner who has conducted a microscopic comparison. A recent wrongful conviction in Canada and an associated Royal Commission has highlighted these problems. A comprehensive new hair examination sequence employing objective techniques will increase the forensic value of human hair, one of the most common evidence types found at crime scenes.Read moreRead less
Fast tracking pea weevil resistance into field pea cultivars through interspecific hybridisation. Field pea is a high value export product of Australia and increased adoption will lead to greater sustainability of agriculture, improved farm income and value adding opportunities (eg. food industry) in regional Australia. Novel breeding tools used within this project will accelerate the development of pea weevil resistant field peas that are less dependent on the application of pesticides than cur ....Fast tracking pea weevil resistance into field pea cultivars through interspecific hybridisation. Field pea is a high value export product of Australia and increased adoption will lead to greater sustainability of agriculture, improved farm income and value adding opportunities (eg. food industry) in regional Australia. Novel breeding tools used within this project will accelerate the development of pea weevil resistant field peas that are less dependent on the application of pesticides than current varieties. Their availability will encourage further uptake of field pea into Australian cropping systems, contributing to environmentally sustainable farming systems by improving soil nitrogen levels and reducing the environmental effect of pesticides.Read moreRead less
The mucosal immune system of fish: analysis of the immune repertoire in gut-and gill-associated lymphoid tissues in trout. Infectious disease causes major economic loss to the aquaculture industry, highlighting the need for effective vaccination strategies. While oral or immersion vaccination represents the most cost effective means of protecting fish against infectious disease there are problems associated with inducing an effective immune response in fish that will assist our industry partner ....The mucosal immune system of fish: analysis of the immune repertoire in gut-and gill-associated lymphoid tissues in trout. Infectious disease causes major economic loss to the aquaculture industry, highlighting the need for effective vaccination strategies. While oral or immersion vaccination represents the most cost effective means of protecting fish against infectious disease there are problems associated with inducing an effective immune response in fish that will assist our industry partner (Novartis Animal Vaccines Ltd) to develop improved fish vaccines. The project will provide postgraduate training in the area of fish immunology that is vital to the developing Australian aquaculture industry.Read moreRead less
Breeding for improved Australian hop varieties by induced mutations. Hop (Humulus lupulus) plants are vital to the brewing industry. Their main commercial products are alpha-acids and oils, which contribute to the bitter taste and aroma of beer. Hops possess different alpha-acids, including humulone (desirable) and cohumulone (non-desirable), and different oils, including humulene (desirable). Recently, beta-acids have been identified as useful compounds for emerging markets. Induced mutagen ....Breeding for improved Australian hop varieties by induced mutations. Hop (Humulus lupulus) plants are vital to the brewing industry. Their main commercial products are alpha-acids and oils, which contribute to the bitter taste and aroma of beer. Hops possess different alpha-acids, including humulone (desirable) and cohumulone (non-desirable), and different oils, including humulene (desirable). Recently, beta-acids have been identified as useful compounds for emerging markets. Induced mutagenesis will be used to alter the genetic make-up of hops, to obtain varieties with: (i) higher humulone; (ii) lower cohumulone; (iii) higher humulene; and (iv) higher beta-acids. This research will greatly assist the Australian hop industry by short-cutting traditional breeding performed by crossing.Read moreRead less
Identification of the targets of a novel metalloproteinase inhibitor used for the treatment of human head lice. Human head lice are difficult to control. This project examines a new type of ovicidal treatment that prevents louse eggs from hatching. The goal is to understand precisely how this treatment is ovicidal, so that even more effective products might be designed. Beyond the benefits of providing a safe and reliable treatment option for a troublesome pest, the development of this product ....Identification of the targets of a novel metalloproteinase inhibitor used for the treatment of human head lice. Human head lice are difficult to control. This project examines a new type of ovicidal treatment that prevents louse eggs from hatching. The goal is to understand precisely how this treatment is ovicidal, so that even more effective products might be designed. Beyond the benefits of providing a safe and reliable treatment option for a troublesome pest, the development of this product will be a significant step forward for the Australian pharmaceutical industry.Read moreRead less
Genetic association studies of fundamental wood fibre components in Pinus radiata resource populations. Radiata pine is Australia's premiere softwood plantation species occupying in excess of one million hectares, contributing over $18 billion to Australia's GNP and providing employment to 130,000 Australians. With a trade deficit in forest and forest products of $1.85 billion, current massive plantation establishment efforts are in train to reverse this trend. These have to be backed by researc ....Genetic association studies of fundamental wood fibre components in Pinus radiata resource populations. Radiata pine is Australia's premiere softwood plantation species occupying in excess of one million hectares, contributing over $18 billion to Australia's GNP and providing employment to 130,000 Australians. With a trade deficit in forest and forest products of $1.85 billion, current massive plantation establishment efforts are in train to reverse this trend. These have to be backed by research into the factors that determine the base resource's quality, growth and sustainability. Results will lead to improved resource quality, increased productivity and new industrial opportunities, directly improving our trade position and releasing pressure on our native forest resources.Read moreRead less
Identification of genes controlling wood fibre properties in Eucalyptus nitens. Australian forestry is shifting to high intensity eucalypt plantations and increasingly focussing on development of breeds and clones with superior wood and pulp traits. Many of these traits are under moderate to strong genetic control and DNA markers have helped identify regions on eucalypt chromosomes that influence these traits. This project aims to identify the genes at these chromosomal locations that influence ....Identification of genes controlling wood fibre properties in Eucalyptus nitens. Australian forestry is shifting to high intensity eucalypt plantations and increasingly focussing on development of breeds and clones with superior wood and pulp traits. Many of these traits are under moderate to strong genetic control and DNA markers have helped identify regions on eucalypt chromosomes that influence these traits. This project aims to identify the genes at these chromosomal locations that influence wood fibre development and which have a strong influence on major commercial traits. The project will increase our understanding of wood and fibre development in eucalypts, and facilitate development of genetic markers to track superior genes during breeding.Read moreRead less
Advanced animal breeding in aquaculture: using genome-wide molecular breeding values for rapid animal improvement in the silver-lipped pearl oyster. The primary impediment to achieving rapid genetic progress in aquaculture is an inability to accurately and rapidly identify high-performance animals for selection as parents in animal breeding programs. This project aims to develop an innovative genomic selection breeding system for the silver-lipped pearl oyster to overcome current limitations ass ....Advanced animal breeding in aquaculture: using genome-wide molecular breeding values for rapid animal improvement in the silver-lipped pearl oyster. The primary impediment to achieving rapid genetic progress in aquaculture is an inability to accurately and rapidly identify high-performance animals for selection as parents in animal breeding programs. This project aims to develop an innovative genomic selection breeding system for the silver-lipped pearl oyster to overcome current limitations associated with traditional animal improvement methods. The use of genomic selection will not only transform the Australian pearl oyster industry, but it will also showcase the potential of genomic selection in aquaculture globally. Furthermore, knowledge gained from this project can also be applied to a variety of other Australian aquaculture species to accelerate the uptake of this technology.Read moreRead less