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The genomic programming of complex organisms. The project will have far-reaching consequences in medicine, agriculture, biotechnology, engineering, information science and associated industries. It will provide a platform for the rationalization of genetic epidemiology and genetic improvement programs, the development of a wide range of new diagnostics and therapies, the development of new core technologies and practical approaches in genetics and genetic diversity, a framework for advanced gen ....The genomic programming of complex organisms. The project will have far-reaching consequences in medicine, agriculture, biotechnology, engineering, information science and associated industries. It will provide a platform for the rationalization of genetic epidemiology and genetic improvement programs, the development of a wide range of new diagnostics and therapies, the development of new core technologies and practical approaches in genetics and genetic diversity, a framework for advanced genetic engineering, the development of new principles and systems for information storage and transmission, and the design of artificial systems capable of self-referential assembly in other environments.Read moreRead less
Role of an ancient genetic program in the elaboration of plant architecture. This proposal will reveal how plant architecture is controlled by genes. Ultimately it will help us manipulate plant form tailored for Australia's crops, pastures and plantations. Potential benefits include larger leaves, more fruits and seeds, and timbers with new properties. As a young researcher I bring a strong and growing international reputation in plant molecular developmental genetics with world-wide collaborati ....Role of an ancient genetic program in the elaboration of plant architecture. This proposal will reveal how plant architecture is controlled by genes. Ultimately it will help us manipulate plant form tailored for Australia's crops, pastures and plantations. Potential benefits include larger leaves, more fruits and seeds, and timbers with new properties. As a young researcher I bring a strong and growing international reputation in plant molecular developmental genetics with world-wide collaborations to build a focus of excellence in Australian plant development research.
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Evaluating the adaptive potential of organisms to respond to environmental change. The program utilizes technological advances to develop a gene inventory for climatic change adaptation, using, as model system, the vinegar fly from divergent climates along eastern Australia. The inventory will result in new methods for monitoring climatic change impact on populations, and for testing adaptive potential of organisms from threatened habitats. A key hypothesis is that these organisms have restricte ....Evaluating the adaptive potential of organisms to respond to environmental change. The program utilizes technological advances to develop a gene inventory for climatic change adaptation, using, as model system, the vinegar fly from divergent climates along eastern Australia. The inventory will result in new methods for monitoring climatic change impact on populations, and for testing adaptive potential of organisms from threatened habitats. A key hypothesis is that these organisms have restricted genetic options to counter environmental change, increasing extinction risk. The program investigates genetic adaptation to pollutants in midges, a key group for monitoring water health. By assessing evolutionary potential and DNA species markers, biological signatures of aquatic pollutants should result.Read moreRead less
Optimism, Pessimism and Confidence - Their economic impacts. When modelling uncertainty, economists typically assume people utilise well-behaved and precise probabilities. As most people have only the vaguest conception of chances of terrorist acts, of contracting SARS, or of extreme market volatility, this limits usefulness of the standard model in predicting or guiding choice. This project aims to incorporate a richer set of attitudes about uncertainty into economic theory, including impreci ....Optimism, Pessimism and Confidence - Their economic impacts. When modelling uncertainty, economists typically assume people utilise well-behaved and precise probabilities. As most people have only the vaguest conception of chances of terrorist acts, of contracting SARS, or of extreme market volatility, this limits usefulness of the standard model in predicting or guiding choice. This project aims to incorporate a richer set of attitudes about uncertainty into economic theory, including imprecise estimates of chance, optimistic (or pessimistic) bias, and relative confidence. This will enable more rigorous analysis of topics like irrational exuberance (panic), consumer stampedes, and (in)tolerance of risk, thereby improving the measurement of benefits and costs of related actions or policies.Read moreRead less
Metabolomic and genetic approaches to the discovery of genes that direct carbon partitioning in plants. Plants make starch, sucrose, cell walls (fibre), oil, organic acids, vitamins and other products of great economic and social importance. The partitioning of carbon resources into such products determines crop productivity and quality. This partitioning is strongly influenced by nutrients, water and salinity. The powerful genomics resources of Arabidopsis including the new discipline of metabo ....Metabolomic and genetic approaches to the discovery of genes that direct carbon partitioning in plants. Plants make starch, sucrose, cell walls (fibre), oil, organic acids, vitamins and other products of great economic and social importance. The partitioning of carbon resources into such products determines crop productivity and quality. This partitioning is strongly influenced by nutrients, water and salinity. The powerful genomics resources of Arabidopsis including the new discipline of metabolomics, will be deployed to understand the regulation of carbon partitioning in leaves and to discover genes that direct partitioning. National research capability will be enhanced and new resources will be generated to breed crops with improved yield potential and product quality under varied environmental conditions.Read moreRead less
Engineering Nanostructured Bio-inspired Products. New nanostructured products that draw on biology promise to revolutionise our lives and economy. Designer emulsions and self-assembling particles inspired by viruses are two such products that form the focus for this research programme. The constitutive behaviour of bio-molecular films that control emulsion performance will be characterised and linked to molecular properties and manufacturing conditions. A broad-based technology platform for t ....Engineering Nanostructured Bio-inspired Products. New nanostructured products that draw on biology promise to revolutionise our lives and economy. Designer emulsions and self-assembling particles inspired by viruses are two such products that form the focus for this research programme. The constitutive behaviour of bio-molecular films that control emulsion performance will be characterised and linked to molecular properties and manufacturing conditions. A broad-based technology platform for the in vitro creation of self-assembling biological nanoparticles will also be developed. Key outcomes will be valuable IPR and fundamental engineering science knowledge to ensure that the value chain for this class of products can deliver commercial outcomes.Read moreRead less
Structural neurobiology - developing a new capability in Australia to treat mental illness. Mental illness encompasses a multitude of devastating conditions that present a major burden to the Australian economy. In this project powerful tools for determining the three-dimensional shapes and functions of proteins will be utilised to gain new knowledge about the molecular bases of various mental illnesses. The project will involve extensive use of the Australian Synchrotron Facility that is due to ....Structural neurobiology - developing a new capability in Australia to treat mental illness. Mental illness encompasses a multitude of devastating conditions that present a major burden to the Australian economy. In this project powerful tools for determining the three-dimensional shapes and functions of proteins will be utilised to gain new knowledge about the molecular bases of various mental illnesses. The project will involve extensive use of the Australian Synchrotron Facility that is due to open in 2007. This knowledge gained from the project will be used to develop new therapeutic drugs to ameliorate or combat mental diseases in partnership with the Australian Biotechnology Industry.Read moreRead less
The conversion of remote location natural gas to fuels and chemicals. The objectives of the research programme will be to develop novel science, engineering and technology that will allow cost efficient conversion of remote gas reserves to liquid fuels and/or chemicals with minimal greenhouse gas emissions. The significance of the proposal rests in the fact that Australia has large remote location gas fields that cannot be exploited but faces, within ten years, trillion dollars a year balance of ....The conversion of remote location natural gas to fuels and chemicals. The objectives of the research programme will be to develop novel science, engineering and technology that will allow cost efficient conversion of remote gas reserves to liquid fuels and/or chemicals with minimal greenhouse gas emissions. The significance of the proposal rests in the fact that Australia has large remote location gas fields that cannot be exploited but faces, within ten years, trillion dollars a year balance of payments deficits due to a shortgae of liquid fuels. The development of new processes for gas to liquids conversion and new technology for existing processes is the essential aim of the proposed research.Read moreRead less
Rethinking Mental Health Laws: An Integrated Approach. Mental health is one of the Commonwealth Government's national health priority areas. This research program will ensure the best possible outcomes for the Government's five-year action plan for better mental health services by developing model legal frameworks that will help shape the way in which individuals with mental illnesses can access the highest attainable standard of mental health care. Through interdisciplinary collaboration and th ....Rethinking Mental Health Laws: An Integrated Approach. Mental health is one of the Commonwealth Government's national health priority areas. This research program will ensure the best possible outcomes for the Government's five-year action plan for better mental health services by developing model legal frameworks that will help shape the way in which individuals with mental illnesses can access the highest attainable standard of mental health care. Through interdisciplinary collaboration and through developing model frameworks for both civil commitment and sentencing laws, this program will enable Australia to set the international agenda as to how countries can best respond to the mental health needs of their citizens.Read moreRead less
Advanced products through multiscale microstructure engineering. The metals manufacturing industry is one of the most important in Australia. Future growth and sustainability of the sector is critically dependent on the development of innovative metal products and materials.. In this program Australia's leading research group in metal manufacturing will develop new products and processes through the controlled manipulation of the microstructure at a number of levels: from nano scale to macro s ....Advanced products through multiscale microstructure engineering. The metals manufacturing industry is one of the most important in Australia. Future growth and sustainability of the sector is critically dependent on the development of innovative metal products and materials.. In this program Australia's leading research group in metal manufacturing will develop new products and processes through the controlled manipulation of the microstructure at a number of levels: from nano scale to macro scale. The areas of application include the automotive industry, biomaterials, surface engineering and the emerging area of microforming technologiesRead moreRead less