Improving Influenza Vaccination Rate For The Prevention Of Cardiovascular Events
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Over the next 5 years, I will become an independent researcher and lead a program of work that improves heart care. My research will assess the association between high dose flu vaccine and the prevention of heart disease and test a general practice quality improvement program to enhance vaccination rate in Australia. This will deepen our understanding of the effect of flu vaccination and provide evidence to assist in generating guidelines/policies to help reduce heart disease among Australians.
Pathogenic Repeat Expansions In Ataxia: Advancing Gene Discovery And Genetic Diagnosis
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Hereditary ataxia is a severe neurological disorder that results in impaired coordination and balance and affects 1 in 20,000 Australians. Ataxias are often caused by complex genetic mutations called repeat expansions (RE), which are difficult to detect. Therefore, genetic diagnosis of ataxia remains limited and poorly accessible, leading to a gap in clinical care. In this study, we will utilise modern advances in genetic sequencing technology to diagnose and discover ataxias caused by REs.
Diagnosing Hereditary Myopathies And Dystrophies With RNA Sequencing: Translating Research Innovations Into Diagnostic Practice
Funder
National Health and Medical Research Council
Funding Amount
$279,725.00
Summary
Despite recent advances in genetic testing, more than 50% of patients with hereditary neuromuscular disorders remain undiagnosed. This project aims to apply an alternative and the newest form of Next Generation Sequencing (NGS) testing strategy known as transciptome or RNA sequencing to clinical practice to further investigate patients who have remained undiagnosed despite WES and WGS.