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Exploiting SNP Data In Epidemiology And Genetics Through Multivariate Analysis Of Complex Traits
Funder
National Health and Medical Research Council
Funding Amount
$476,981.00
Summary
There is overlap in risk factors across multiple diseases, and some of that overlap is due to genetic factors. The availability of genome-wide DNA data on tens of thousands of patients for multiple diseases and healthy controls allows new questions to be asked and answered. For example, what is the overlap due to genes in disease risk for multiple sclerosis and rheumatoid arthritis? This project will develop and statistical genetic methodology to answer such questions and apply those methods to ....There is overlap in risk factors across multiple diseases, and some of that overlap is due to genetic factors. The availability of genome-wide DNA data on tens of thousands of patients for multiple diseases and healthy controls allows new questions to be asked and answered. For example, what is the overlap due to genes in disease risk for multiple sclerosis and rheumatoid arthritis? This project will develop and statistical genetic methodology to answer such questions and apply those methods to a range of important diseases.Read moreRead less
I am a genetic epidemiologist focused on bowel cancer risk. I will develop a comprehensive model to estimate individual cancer risk by studying the effects of personal characteristics, cancer history, genetic factors and family history of cancer using large data sets from international consortia I helped establish. My research will enable targeting of screening to those most at risk and will aid the discovery of new causes for bowel cancer.
Genetic Epidemiology Of Endometrial Cancer: Towards Understanding Aetiology And Improving Risk Prediction.
Funder
National Health and Medical Research Council
Funding Amount
$353,573.00
Summary
Studies investigating thousands of genetic markers have revolutionised our understanding of genes involved in cancer, and shown that a single gene can be associated with multiple cancers. We will conduct the largest ever study to find new genes for endometrial cancer, the most common gynaecological cancer. Our unique approach will examine >11million markers across the genome, some specifically in regions known to be important for other cancers. Findings will be used for risk prediction models ....Studies investigating thousands of genetic markers have revolutionised our understanding of genes involved in cancer, and shown that a single gene can be associated with multiple cancers. We will conduct the largest ever study to find new genes for endometrial cancer, the most common gynaecological cancer. Our unique approach will examine >11million markers across the genome, some specifically in regions known to be important for other cancers. Findings will be used for risk prediction models.Read moreRead less
Germline Mutations In Mismatch Repair Genes: Prevalence, Risk Of Cancer, And Environmental Modifiers Of Risk.
Funder
National Health and Medical Research Council
Funding Amount
$216,750.00
Summary
Aims: 1. Develop a model that will predict who has a mutation in a group of genes that cause cancer 2. Estimate risk of cancer in people who have a mutation in these genes (carriers) 3. Determine if cancer risk in carriers can be reduced People who inherit a mutation in a group of genes called 'mismatch repair genes' are at increased risk of cancer, particularly cancer of the colon and rectum. If these carriers can be identified they can take preventive measures such as screening to reduce their ....Aims: 1. Develop a model that will predict who has a mutation in a group of genes that cause cancer 2. Estimate risk of cancer in people who have a mutation in these genes (carriers) 3. Determine if cancer risk in carriers can be reduced People who inherit a mutation in a group of genes called 'mismatch repair genes' are at increased risk of cancer, particularly cancer of the colon and rectum. If these carriers can be identified they can take preventive measures such as screening to reduce their risk of cancer and death. We will develop a model using data from the Colon Cancer Family Registry (CFR), the world's largest dataset of carriers and non-carriers which has already recruited and genetically tested over 4,000 families from Australasia, USA and Canada. The model will allow clinicians to predict who is a likely be a carrier based so they can be tested for the mutation. We know the risk of cancer is high in carriers, but we don't have precise estimates. We will use the Colon CFR applying sophisticated statistical methods required to answer this question. This data is critical for genetic counselling so appropriate decisions can be made by the patient and the doctor as to what preventive measures to take. We will also use the Colon CFR data to find out what how the carriers who develop cancer differ from those who stay cancer free using their completed lifestyle questionnaires which includes questions on diet, smoking, alcohol consumption, exercise, aspirin use, and oral contraceptive pill use. We may identify risk factors that carriers can avoid (or take up if they reduce cancer risk) to reduce their risk of cancer.Read moreRead less
The Epidemiology Of Multiple Myeloma In Australia (EMMA)
Funder
National Health and Medical Research Council
Funding Amount
$1,525,729.00
Summary
In Australia, over 1,000 people are diagnosed with multiple myeloma annually. Our proposal aims to identify possible environmental and genetic causes of this serious disease. People diagnosed with myeloma, and their family members, will provide detailed personal and family histories. We plan to investigate the role of sun exposure, body size and obesity, dietary factors and pesticides as well as a large range of genetic variants. The 5-year study will be conducted in Victoria and NSW.
The Australian Twin Registry (ATR) is a volunteer registry of over 30,000 twin pairs willing to consider participation in health research. This national resource was established in the 1980s with NHMRC support because twin studies play a unique, powerful role in research on the impact of genetic and environmental factors on health. Over 400 studies have benefited. The ATR seeks on-going funding to remain internationally competitive and meet increasing demand due to advances in genetic research.
Collaborative Australian Renal Cell Carcinoma Epidemiology Study (CARES)
Funder
National Health and Medical Research Council
Funding Amount
$1,677,048.00
Summary
The objective of this project is to increase our knowledge of the causes of renal cell carcinoma, a relatively common, yet understudied, cancer and use this new knowledge to develop a risk prediction tool to provide a rational basis for risk counselling. The proposed project will establish a biobank and generate a research platform that, beyond the duration of the project, will allow us to identify diagnostic and prognostic biomarkers, and therapeutic targets.
Genetic And Environmental Risk Factors For Food Allergy In Australian Children
Funder
National Health and Medical Research Council
Funding Amount
$299,564.00
Summary
This project aims to provide important information on the role that genetic and environmental factors have in the development of food allergy in Australian children. The study will enable us to understand better the natural history of food allergy in infancy and early childhood and will help to identify risk factors for the development and resolution of food allergy. The results of this study will have implications for clinical guidelines and public health policy.
A Case Control Study Of Risk Factors For Aggressive Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$1,592,353.00
Summary
Although most prostate cancers are not fatal, some develop into an aggressive form that is likely to progress and kill. How this happens and how to prevent these cancers, is not well understood. The study will examine the lives of men with aggressive prostate cancer, from the time of conception to adulthood, their family history and genetic characteristics to identify the role of life patterns and genes in the development of these cancers, seeking a basis for their prevention .