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Dissecting Genetic Variation For Human Complex Diseases And Traits
Funder
National Health and Medical Research Council
Funding Amount
$135,821.00
Summary
Understanding the pattern of inheritance for human common diseases such as cancers, obesity, diabetes and mental illness, is of key importance for disease diagnosis, treatment and prevention. In this project, we will develop statistical methods and software tools to analyse DNA and clinical data to better understand the genetic basis of human common diseases and to predict a person�s risk of developing disease.
Genes, Biology And Environment In The Development Of Substance Use And Mental Health Disorders
Funder
National Health and Medical Research Council
Funding Amount
$475,910.00
Summary
Substance use and mental health disorders are major public health problems which cause long-term disabilities, poor health and early mortality. Addressing these problems requires a better understanding of the genetic, biological and environmental factors leading to these disorders. This research program represents a unique opportunity to increase our knowledge of the origins and mechanisms behind these disorders and significantly contribute to improved substance use and mental health prevention ....Substance use and mental health disorders are major public health problems which cause long-term disabilities, poor health and early mortality. Addressing these problems requires a better understanding of the genetic, biological and environmental factors leading to these disorders. This research program represents a unique opportunity to increase our knowledge of the origins and mechanisms behind these disorders and significantly contribute to improved substance use and mental health prevention policies and programs.Read moreRead less
Novel Genetic And Environmental Modifiers Of The Risk Of Iron Overload-related Disease In HFE-associated Hereditary Haemochromatosis In Cohort Of Middle-aged Australians
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
People who carry mutations in the HFE gene are pre-disposed to body iron overload but not all of them developed subsequent disease. According to the investigators of the “HealthIron” study in Melbourne, only 28% of men and 1% of women with faulty HFE genes go on to develop disease. This study has recruited more than 1,000 people from the community, and will determine which environmental and genetic risk factors stop people with iron overload from getting symptoms of disease.
Allergies And Chronic Respiratory Diseases: Causes, Biological Pathways And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$420,872.00
Summary
Allergies and chronic respiratory diseases are major causes of illness and death in Australia. Worryingly there are still many gaps in knowledge on how best to prevent and manage these diseases. The proposed program will investigate these questions and provide evidence to guide health policy and clinical management. As this program is built on state-of the-art methods and technology, these original Australian findings will be of great importance internationally.
Investigating Biological And Genetic Risk Factors For Autism Spectrum Disorders
Funder
National Health and Medical Research Council
Funding Amount
$394,264.00
Summary
Autism Spectrum Disorder (ASD) is a debilitating developmental disorder affecting around 1% of Australians. This research involves a series of cohesive studies utilising internationally unique population samples, to investigate the relationship between increased prenatal androgen exposure, enlarged head circumference, ASD behavioural traits, and genetic variants. This research aims to reveal new information about the biological and genetic mechanisms underpinning ASD.
Using Epidemiological Methods To Investigate How Genetic, Environmental And Lifestyle Factors Influence Cancer Incidence And Cancer Survivorship; And Translation Into Cancer Prevention And Policy Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
This research program focuses on investigating genetic, environmental and lifestyle causes of cancer, preventing new cases of cancer, and improving outcomes after a cancer diagnosis, particularly for melanoma and gynaecological cancer, which carry a heavy burden in the Australian population. The research will also inform the best allocation of health system resources for cancer control, and ensure translation of research findings into cancer prevention, clinical practice and policy outcomes.
Integrating Statistical Imputation Of HLA And KIR Alleles Into Studies Of Disease In Diverse Human Populations
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
Immune system genes are strongly implicated in many infectious and autoimmune diseases, as well as cancer. Some of these genes have many possible types due to natural selection in response to pathogens. This variability makes typing these genes very expensive. Developing accurate and inexpensive methods to type these genes is vital in understanding the role they play in susceptibility and progression of disease and will be important for the development of better diagnostic tests and treatments.