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Discovery Early Career Researcher Award - Grant ID: DE240100635
Funder
Australian Research Council
Funding Amount
$448,801.00
Summary
Understanding the development of lifestyle behaviours in early childhood. This project adopts novel statistical modelling and machine learning approaches to understand the development of lifestyle behaviours in early childhood. Despite the pivotal role of lifestyle behaviours in influencing health and quality of life, little research exists on lifestyle behaviours in early childhood. This project will establish a comprehensive understanding of lifestyle behaviours in early childhood by identifyi ....Understanding the development of lifestyle behaviours in early childhood. This project adopts novel statistical modelling and machine learning approaches to understand the development of lifestyle behaviours in early childhood. Despite the pivotal role of lifestyle behaviours in influencing health and quality of life, little research exists on lifestyle behaviours in early childhood. This project will establish a comprehensive understanding of lifestyle behaviours in early childhood by identifying key developmental time points, mechanisms of behavioural change, and children at risk of developing poor lifestyle behaviours. The project will inform strategies and policies to optimise lifestyle behaviours from the start of life and showcase the capabilities of novel methods in advancing behavioural epidemiology.Read moreRead less
Drivers of ageing and adaptive ageing in middle-aged and older adults. This project aims to answer crucial questions about how our early years influence our health and wellbeing in middle and later life. Drawing on one of Australia’s longest running studies of social and emotional development, we link decades of developmental data collected since 1983 to social, emotional, cognitive and physical wellbeing in participants turning 40 (midlife) and 70 (later life). It will provide insight into impo ....Drivers of ageing and adaptive ageing in middle-aged and older adults. This project aims to answer crucial questions about how our early years influence our health and wellbeing in middle and later life. Drawing on one of Australia’s longest running studies of social and emotional development, we link decades of developmental data collected since 1983 to social, emotional, cognitive and physical wellbeing in participants turning 40 (midlife) and 70 (later life). It will provide insight into important and largely unanswered questions about the way social factors in the first half of life shape our later selves. This study will inform government and health policy targeting ageing populations.
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Life Expectancy among Disease-Diagnosed. This project aims to improve methodological tools for calculating life expectancy for populations with mental or physical disorders in Australia as well as to determine gains and losses in terms of excess mortality. To achieve this goal innovative measures, which solve methodological previous shortcoming regarding different age at diagnosis will be applied. The expected outcomes of the project include precise figures of excess mortality related to mental ....Life Expectancy among Disease-Diagnosed. This project aims to improve methodological tools for calculating life expectancy for populations with mental or physical disorders in Australia as well as to determine gains and losses in terms of excess mortality. To achieve this goal innovative measures, which solve methodological previous shortcoming regarding different age at diagnosis will be applied. The expected outcomes of the project include precise figures of excess mortality related to mental and physical disorders. Significant benefits for future public policy-making will be gained by analysing excess mortality among individuals diagnosed mental or physical disorders, and cross-country comparisons using national linkage data. Read moreRead less
Enhancing Grain Yield Potential and Quality of Lupin. Sustainability of wheat production in Western Australia depends on the continued use of legumes, specifically lupins, in farming systems. The low returns to growers for lupins has jeopardised these sustainable systems. This project aims to gather new information to develop novel genetic strategies to increase yield potential and modify seed composition in lupins, enhancing their commercial worth.
Monotreme immune system provides insights into their evolutionary relationships. Genes of immunological importance will be cloned and characterised from the short-beaked echidna with the purpose of investigating the immune system in monotremes, gaining insights into the timing and order of evolutionary separation of the three extant mammalian groups:- the Prototherians (monotremes), the Metatherians (marsupials) and Eutherians (placentals), increasing understanding of the evolution of the verteb ....Monotreme immune system provides insights into their evolutionary relationships. Genes of immunological importance will be cloned and characterised from the short-beaked echidna with the purpose of investigating the immune system in monotremes, gaining insights into the timing and order of evolutionary separation of the three extant mammalian groups:- the Prototherians (monotremes), the Metatherians (marsupials) and Eutherians (placentals), increasing understanding of the evolution of the vertebrate immune system and providing the basis for making immunological reagents which are necessary for studying monotreme diseases (as a precautionary conservation strategy).Read moreRead less
Identifying potential barriers to transplanting modified forms of the CO2-fixing enzyme, Rubisco, into plants. Improving the ability of crops to use water, light and fertiliser more efficiently would have economic benefits and ease the environmental impacts associated with agricultural practices. It is thought that such improvements can be made by enhancing the efficiency of the photosynthetic protein, Rubisco, which fixes most of the CO2 in the biosphere. The research proposed here uses unique ....Identifying potential barriers to transplanting modified forms of the CO2-fixing enzyme, Rubisco, into plants. Improving the ability of crops to use water, light and fertiliser more efficiently would have economic benefits and ease the environmental impacts associated with agricultural practices. It is thought that such improvements can be made by enhancing the efficiency of the photosynthetic protein, Rubisco, which fixes most of the CO2 in the biosphere. The research proposed here uses unique Rubisco transplantation capabilities that I have developed to improve our fundamental understanding of how Rubisco is processed and its activity regulated in plants. This will pave the way for our ongoing efforts to engineer and transplant more efficient Rubisco into crops.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101210
Funder
Australian Research Council
Funding Amount
$431,476.00
Summary
Social Inequalities in Oral Health among Australian Working Age Adults. Australian working age adults with social and economic disadvantage have significantly poorer oral health outcomes than those from advantaged backgrounds. This project explores how changes in social position over time, and interactions between different forms of social disadvantage, contribute to social inequalities in oral health. This project expects to improve understanding of social inequalities in oral health, and its s ....Social Inequalities in Oral Health among Australian Working Age Adults. Australian working age adults with social and economic disadvantage have significantly poorer oral health outcomes than those from advantaged backgrounds. This project explores how changes in social position over time, and interactions between different forms of social disadvantage, contribute to social inequalities in oral health. This project expects to improve understanding of social inequalities in oral health, and its solutions, by developing and applying analytical and simulation models. This will help identify ways to reduce the persistent social inequalities in oral health outcomes in working age adults. In doing this, it will inform policies in future that will significantly improve the well-being of Australian working age adults.Read moreRead less
A knockout approach to identifying genes involved in epidermal development and homeostasis. These studies will identify new genes which play a role in the development or maintenance of the skin, some of which may subsequently be shown to play a role in disease. The project capitalises on an investment of tens of millions of dollars by the Wellcome Trust in generating a significant cohort of knockout mice. Our involvement in this international initiative will ensure Australia's participation in ....A knockout approach to identifying genes involved in epidermal development and homeostasis. These studies will identify new genes which play a role in the development or maintenance of the skin, some of which may subsequently be shown to play a role in disease. The project capitalises on an investment of tens of millions of dollars by the Wellcome Trust in generating a significant cohort of knockout mice. Our involvement in this international initiative will ensure Australia's participation in a project at the forefront of mouse genetics, using cutting edge infrastructure and technologies to provide insights into the complement of genes involved in skin biology. Models of interest will be repatriated to Australia for further study capitalising on existing infrastructure provided through the NCRIS funding program. Read moreRead less
Actin cytoskeleton regulation by E-cadherin and Src. This project examines a fundamental, novel mechanism of how cells work together in tissues. It will provide important new knowledge about how tissues become organized in health, and how organization might be disturbed in disease. It will build Australia's skill base in cutting-edge scientific research, and promote knowledge directed to the research priority area of Promoting and Maintaining Good Health.
How the Y Chromosome makes a male: Molecular genetic analysis of key sex-determining genes. Sex reversal and intersex syndromes are among the most common and highly stigmatized disorders affecting newborn babies. Our research will reveal how the Y chromosome regulates normal male development, identify the steps that go wrong in many male babies, and suggest ways to diagnose and deal with these conditions. It will also pave the way for biotechnological applications in the areas of stem cell techn ....How the Y Chromosome makes a male: Molecular genetic analysis of key sex-determining genes. Sex reversal and intersex syndromes are among the most common and highly stigmatized disorders affecting newborn babies. Our research will reveal how the Y chromosome regulates normal male development, identify the steps that go wrong in many male babies, and suggest ways to diagnose and deal with these conditions. It will also pave the way for biotechnological applications in the areas of stem cell technology, pest management, wildlife conservation and animal breeding.Read moreRead less