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The efficacy of a physical activity intervention in the management of psychological and physical symptoms among breast and prostate cancer patients. The vastly improved survival rates for breast and prostate cancer in recent years has resulted in an ever-increasing number of people living with a history of cancer. Treatment for cancer is often associated with negative side effects like fatigue, depression and sleep disturbance, and an overall impaired quality of life.
This project will assess ....The efficacy of a physical activity intervention in the management of psychological and physical symptoms among breast and prostate cancer patients. The vastly improved survival rates for breast and prostate cancer in recent years has resulted in an ever-increasing number of people living with a history of cancer. Treatment for cancer is often associated with negative side effects like fatigue, depression and sleep disturbance, and an overall impaired quality of life.
This project will assess the effectiveness of a physical activity program in alleviating these symptoms of treatment. The program will include regular walking and gentle resistance strength training.
The outcomes from the project will advance research by shedding light on which symptoms are most helped by physical activity, and how much activity is needed to gain these benefits.
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Multiple perspectives on sexuality and intimacy post-cancer, leading to the development and evaluation of supportive interventions. In 2006, over 106,000 new cases of cancer were diagnosed in Australia, impacting on the quality of life of patients and their partners. A significant proportion of couples report cessation of sexual and intimate contact post-cancer, resulting in considerable distress. To date, there has been no examination of this important health concern across a broad range of can ....Multiple perspectives on sexuality and intimacy post-cancer, leading to the development and evaluation of supportive interventions. In 2006, over 106,000 new cases of cancer were diagnosed in Australia, impacting on the quality of life of patients and their partners. A significant proportion of couples report cessation of sexual and intimate contact post-cancer, resulting in considerable distress. To date, there has been no examination of this important health concern across a broad range of cancer types, from the perspective of patients and their partners. Equally, support services rarely address sexuality issues post-cancer. This project will benefit people with cancer and their partners through examining pathways to distress, and developing programs to facilitate re-negotiation of sexuality and intimacy, post-cancer.Read moreRead less
Discovery of novel microRNA biogenesis and functional components. Discovery of novel microRNA components will provide new strategies for confronting a diverse array of challenges Australia faces, such as the increasing rates of certain cancers in our population, to stresses on our crop plants faced with environmental changes. The biological mechanisms underlying these disparate problems are unified by microRNA involvement in many instances. By finding microRNA controlling factors common to all h ....Discovery of novel microRNA biogenesis and functional components. Discovery of novel microRNA components will provide new strategies for confronting a diverse array of challenges Australia faces, such as the increasing rates of certain cancers in our population, to stresses on our crop plants faced with environmental changes. The biological mechanisms underlying these disparate problems are unified by microRNA involvement in many instances. By finding microRNA controlling factors common to all higher organisms, we expect our community will benefit from the increased knowledge base that will help our researchers adopt new strategies in fighting diseases and improving our agricultural industry.Read moreRead less
The effectiveness of pro-active telemarketing of a smoking cessation telephone counselling service. Despite the availability of services, such as telephone support lines to help people quit, only a small number of smokers seek help. One solution is to pro-actively contact and offer support with quitting to smokers in the community. This study will involve pro-actively contacting households by telephone and offering intensive, personalised telephone counselling to smokers to support them in the q ....The effectiveness of pro-active telemarketing of a smoking cessation telephone counselling service. Despite the availability of services, such as telephone support lines to help people quit, only a small number of smokers seek help. One solution is to pro-actively contact and offer support with quitting to smokers in the community. This study will involve pro-actively contacting households by telephone and offering intensive, personalised telephone counselling to smokers to support them in the quitting process. Such a service will provide treatment to smokers who might not otherwise seek assistance to quit, thereby greatly increasing the potential impact of quit smoking services at a community level.Read moreRead less
Adaptive Evolution of BRCA1 in Ancestral Mammals. This project investigates adaptive evolution of BRCA1 in the early radiation of mammals. We will test the hypothesis that the evolution of mammary glands and X chromosome inactivation has resulted in modification of the BRCA1 protein sequence as it aquired new roles in these processes. We will also investigate the importance of these changes inducing compensatory changes in other parts of the protein.
An evaluation of concerns, self-perceived needs, and supportive interventions, for informal cancer carers: A comparative study of female and male carers. Informal cancer carers experience high levels of anxiety, depression, and unmet support needs, with women carers at higher risk than men. However, little is known about the factors underlying this gender difference, and existing support services have not specifically targeted the needs of female and male cancer carers. This study will explore t ....An evaluation of concerns, self-perceived needs, and supportive interventions, for informal cancer carers: A comparative study of female and male carers. Informal cancer carers experience high levels of anxiety, depression, and unmet support needs, with women carers at higher risk than men. However, little is known about the factors underlying this gender difference, and existing support services have not specifically targeted the needs of female and male cancer carers. This study will explore the concerns, self-perceived needs, and psychological wellbeing of informal cancer carers living in New South Wales, comparing the experiences of female and male carers, at different stages of the care-giving journey. Based on these findings, a program of targeted supportive interventions will be developed, and then systematically evaluated within a controlled trial.Read moreRead less
Meeting the needs of cancer support group leaders. Social support plays a pivotal role in the psychological adjustment of people with cancer. Support groups provide unique input, but their outcomes are reliant on the quality and sustainability of the leaders. Internationally, little is known about the challenges and unmet needs of cancer support group leaders, or how to best support them. This study will:
a) clarify the needs of cancer group leaders
b) design and evaluate two interventions (mi ....Meeting the needs of cancer support group leaders. Social support plays a pivotal role in the psychological adjustment of people with cancer. Support groups provide unique input, but their outcomes are reliant on the quality and sustainability of the leaders. Internationally, little is known about the challenges and unmet needs of cancer support group leaders, or how to best support them. This study will:
a) clarify the needs of cancer group leaders
b) design and evaluate two interventions (minimal and intense) to meet the needs of leaders.
If successful, this study will provide the evidence on which cancer organizations around the world can base interventions to sustain cancer support group leaders and thus hopefully improve psychological outcomes for cancer patients and their carers.Read moreRead less
Zinc finger domains as scaffolds for protein engineering. While great advances have been made in pharmaceutical design and discovery, it is clear that new types of drugs are needed for the better management of a wide range of diseases (e.g. cancers, autoimmune diseases, viral infections). Many of these diseases arise from inappropriate interactions between intracellular biological macromolecules. My aim is to develop a range of novel therapeutic proteins based on naturally existing zinc-binding ....Zinc finger domains as scaffolds for protein engineering. While great advances have been made in pharmaceutical design and discovery, it is clear that new types of drugs are needed for the better management of a wide range of diseases (e.g. cancers, autoimmune diseases, viral infections). Many of these diseases arise from inappropriate interactions between intracellular biological macromolecules. My aim is to develop a range of novel therapeutic proteins based on naturally existing zinc-binding protein domains with the goal of selectively blocking these inappropriate interactions. Additionally, these engineered proteins have potential uses as biochemical tools such as to help delineate the functions of natural proteins with no known functions.Read moreRead less
Transcriptional and epigenetic regulation of terminal lymphocyte differentiation and alterations of the same that lead to leukemia. In the developed world infection diseases are the number three killer behind heart disease and cancer, and huge financial effort is put into treatment and prevention. Despite this, results have often been disappointing. One cause of these poor outcomes is the lack of knowledge of how effective immune responses are generated. This project aims to better understand th ....Transcriptional and epigenetic regulation of terminal lymphocyte differentiation and alterations of the same that lead to leukemia. In the developed world infection diseases are the number three killer behind heart disease and cancer, and huge financial effort is put into treatment and prevention. Despite this, results have often been disappointing. One cause of these poor outcomes is the lack of knowledge of how effective immune responses are generated. This project aims to better understand the processes that control the generation of protective lymphocytes. It will deliver information that may enable a more targeted approach to vaccine-development and treatments of infections. As defective differentiation can also be a cause of leukemia it may also lead to targets of cancer treatment.Read moreRead less
Specific gene inhibition through functional genomics and high through-put small molecule screening. This project will utilise functional genomic technologies in an attempt to identify genes in childhood neuroblastoma as potential candidates for the future development of molecular-targeted gene therapy. By screening large 'libraries' of chemical compounds, we aim to identify compounds with the ability to specifically inhibit these gene targets. This project will therefore define novel molecular t ....Specific gene inhibition through functional genomics and high through-put small molecule screening. This project will utilise functional genomic technologies in an attempt to identify genes in childhood neuroblastoma as potential candidates for the future development of molecular-targeted gene therapy. By screening large 'libraries' of chemical compounds, we aim to identify compounds with the ability to specifically inhibit these gene targets. This project will therefore define novel molecular targets and possibly facilitate the future development of new therapeutic approaches to treating neuroblastoma. In addition, the project will develop know-how that can be utilised by both the industry partner and the broader research community and will introduce to Australian science novel techniques and skills. Read moreRead less