Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease le ....Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease leading to the potential identification of new drug and vaccine targets. The methodologies and expertise developed will be used will be available to other research groups working on infectious diseases.Read moreRead less
Healthy infant and young child diets from sustainable first-food systems. Breastfeeding, breastmilk and other first foods consumed during infancy and early childhood, are currently neglected in food systems research and policy action, despite their importance to establishing life-long dietary preferences, health and sustainability. This project addresses this gap, by developing a novel 'first-food systems' conceptual framework, describing global, regional and national changes in infant and young ....Healthy infant and young child diets from sustainable first-food systems. Breastfeeding, breastmilk and other first foods consumed during infancy and early childhood, are currently neglected in food systems research and policy action, despite their importance to establishing life-long dietary preferences, health and sustainability. This project addresses this gap, by developing a novel 'first-food systems' conceptual framework, describing global, regional and national changes in infant and young child diets, and generating end-user knowledge to generate political commitment for early-life nutrition. This research will deliver economic, social and environmental benefits for Australia and international communities, by helping to reduce the ill-health and environmental harms linked with unhealthy early-life diets.Read moreRead less
How is the blood cell population size controlled? Macrophage-like cells are an ancient animal blood cell lineage critically important for development, immunity, and homeostasis. This fellowship seeks to reveal the genes and control mechanisms used by animals to achieve an optimally-sized army of these cells - to contain threats for survival upon infection, heal following acute stress exposures, or for development, ongoing maintenance, and repair of wear and tear. By marrying the genetic tractabi ....How is the blood cell population size controlled? Macrophage-like cells are an ancient animal blood cell lineage critically important for development, immunity, and homeostasis. This fellowship seeks to reveal the genes and control mechanisms used by animals to achieve an optimally-sized army of these cells - to contain threats for survival upon infection, heal following acute stress exposures, or for development, ongoing maintenance, and repair of wear and tear. By marrying the genetic tractability of the model organism Drosophila and its simple, yet conserved blood cell system, this project will yield new insights into the mechanisms that govern the animal blood cell population. This will benefit our fundamental understanding of how animals maximise their health throughout life.Read moreRead less
Excessive sitting and population health: strengthening the science and the relevance to policy and practice. The majority of Australian adults spend most of their waking hours sitting; this increases the likelihood of developing diseases of inactivity, including diabetes, heart disease and some cancers. New research will investigate what factors encourage excessive sitting and what the health benefits are for people who deliberately do less sitting.
Agreements as a mechanism for community participation in health policy: Understanding process and evaluating effectiveness. Improving the health of Indigenous people requires health policy that is inclusive and proactive rather than crisis driven. Formal agreements outline responsibilities and accountabilities in a shared framework that respects the rights of the parties involved. This project will evaluate the quality and effectiveness of agreements in Indigenous health by assessing their abil ....Agreements as a mechanism for community participation in health policy: Understanding process and evaluating effectiveness. Improving the health of Indigenous people requires health policy that is inclusive and proactive rather than crisis driven. Formal agreements outline responsibilities and accountabilities in a shared framework that respects the rights of the parties involved. This project will evaluate the quality and effectiveness of agreements in Indigenous health by assessing their ability to change the way governments and communities work together to improve health. The project will help ensure that future agreements reflect shared solutions for improving the health of Indigenous people in a respectful and effective way. It will also determine whether agreements work to bring community and government together to reduce inequalities in health.Read moreRead less
Transcriptional and epigenetic regulation of terminal lymphocyte differentiation and alterations of the same that lead to leukemia. In the developed world infection diseases are the number three killer behind heart disease and cancer, and huge financial effort is put into treatment and prevention. Despite this, results have often been disappointing. One cause of these poor outcomes is the lack of knowledge of how effective immune responses are generated. This project aims to better understand th ....Transcriptional and epigenetic regulation of terminal lymphocyte differentiation and alterations of the same that lead to leukemia. In the developed world infection diseases are the number three killer behind heart disease and cancer, and huge financial effort is put into treatment and prevention. Despite this, results have often been disappointing. One cause of these poor outcomes is the lack of knowledge of how effective immune responses are generated. This project aims to better understand the processes that control the generation of protective lymphocytes. It will deliver information that may enable a more targeted approach to vaccine-development and treatments of infections. As defective differentiation can also be a cause of leukemia it may also lead to targets of cancer treatment.Read moreRead less
Closing the gap in Aboriginal maternal and child health outcomes. This project will build the evidence base needed to design and implement effective strategies to close the gap in Aboriginal maternal and child health outcomes and reduce Indigenous disadvantage across the life course.
Reducing the burden of alcohol and other drug use in Australia. The costs of alcohol and other drug use to the Australian community are significant. This research will aim to reduce this burden by developing the evidence for effective intervention and then working with policymakers and practitioners to improve responses to alcohol and other drugs in the community.
Modelling the population impact of injury. This project aims to model the long-term, population impact of non-fatal injury through the use of cutting edge epidemiological modelling, sophisticated biostatistics, advanced econometrics, and geospatial analysis. The project will use population-based, linked longitudinal data to generate new knowledge about the long-term impacts of injury, cost of injury, and expected burden into the future. Through the multi-disciplinary and multi-national collabo ....Modelling the population impact of injury. This project aims to model the long-term, population impact of non-fatal injury through the use of cutting edge epidemiological modelling, sophisticated biostatistics, advanced econometrics, and geospatial analysis. The project will use population-based, linked longitudinal data to generate new knowledge about the long-term impacts of injury, cost of injury, and expected burden into the future. Through the multi-disciplinary and multi-national collaborations established, it is anticipated that this project may lead to future changes in public health and social policy, prioritisation of injury prevention efforts, and establish the capacity to evaluate injury interventions and policy shifts as they occur.Read moreRead less
Health insurance design: choices, consumer behavior and policy challenges . Rising health costs is a global challenge. Creating an efficient health insurance system is a key policy concern in all developed countries. This project aims to study choices, consumer behaviors, and policy challenges in two health insurance markets: Australian private health insurance (PHI) and US Medicare prescription drug insurance.
Expected outcomes include new evidence needed to develop a new framework for PHI, ne ....Health insurance design: choices, consumer behavior and policy challenges . Rising health costs is a global challenge. Creating an efficient health insurance system is a key policy concern in all developed countries. This project aims to study choices, consumer behaviors, and policy challenges in two health insurance markets: Australian private health insurance (PHI) and US Medicare prescription drug insurance.
Expected outcomes include new evidence needed to develop a new framework for PHI, new knowledge on how consumers respond to complex pricing structures, and new policy proposals to improve the overall efficiency of the health system. The research will benefit the re-design of PHI and the health system to improve Australians’ health while saving health costs.
Read moreRead less