Exploiting SNP Data In Epidemiology And Genetics Through Multivariate Analysis Of Complex Traits
Funder
National Health and Medical Research Council
Funding Amount
$476,981.00
Summary
There is overlap in risk factors across multiple diseases, and some of that overlap is due to genetic factors. The availability of genome-wide DNA data on tens of thousands of patients for multiple diseases and healthy controls allows new questions to be asked and answered. For example, what is the overlap due to genes in disease risk for multiple sclerosis and rheumatoid arthritis? This project will develop and statistical genetic methodology to answer such questions and apply those methods to ....There is overlap in risk factors across multiple diseases, and some of that overlap is due to genetic factors. The availability of genome-wide DNA data on tens of thousands of patients for multiple diseases and healthy controls allows new questions to be asked and answered. For example, what is the overlap due to genes in disease risk for multiple sclerosis and rheumatoid arthritis? This project will develop and statistical genetic methodology to answer such questions and apply those methods to a range of important diseases.Read moreRead less
Evaluating The Genetic Contribution To Rheumatic Heart Disease Pathogenesis In Australian Aboriginal And Torres Strait Islander Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,782,074.00
Summary
Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.
Identification Of Novel Common Genetic Risk Factors For Endometriosis
Funder
National Health and Medical Research Council
Funding Amount
$593,783.00
Summary
Multiple genetic factors underlie susceptibility to endometriosis—a common gynaecological disease associated with severe pelvic pain and sub-fertility. Through the identification of novel genetic risk factors and pathway-based analyses, this project will increase our understanding of the underlying genetic architecture and complex molecular pathways of endometriosis and lead to the development of diagnostic tests and rational treatment strategies.
Tackling Heterogeneity In The Etiology Of Major Depressive Disorder
Funder
National Health and Medical Research Council
Funding Amount
$2,552,669.00
Summary
Professor Martin and his team will join an international effort to identify the first 50 genes that underlie depression. They aim to recruit 20,000 participants for this study and hope that the outcomes of their research will contribute not only to the development of better treatments for depression, but more targeted therapies for individuals affected.
The Aetiology Of Dental Caries - The Role Of Longitudinal Changes In The Oral Microbiome
Funder
National Health and Medical Research Council
Funding Amount
$288,637.00
Summary
This study will examine the association between changes in the composition of the oral bacteria over time and the development and progression of dental decay in Australian children.
Genome-wide Association Study (GWAS) For Juvenile-onset Myopia And Its Component Measures To Identify Molecular Pathways To Prevent Myopia
Funder
National Health and Medical Research Council
Funding Amount
$495,364.00
Summary
We will examine 2,000 young adults from the Western Australian Raine Cohort at the Lions Eye Institute / University of Western Australia. Ocular data will be collected relating to myopia (short-sightedness) and will be combined with extensive previous childhood and genetic research data collected on the Cohort, to investigate the genetic and environmental factors predisposing to myopia. This will assist in understanding the factors leading to myopia.
DNA Barcoding Of Pathogenic Fungi As The Basis For The Development Of Novel Standardized Diagnostic Tools
Funder
National Health and Medical Research Council
Funding Amount
$560,398.00
Summary
Fungal infections are increasing and have major health impacts, with a high economic burden. Timely initiation of therapy is the key to improve patient outcomes. However, reliable identification tools for fungal pathogens are lacking. We will use comparative genome analysis to develop unique fungal signatures (DNA barcodes) and establish an online database to allow for rapid identification for diagnosis in the clinical setting and as a quarantine tool for border protection.
CAGE: Consortium For The Architecture Of Gene Expression
Funder
National Health and Medical Research Council
Funding Amount
$501,080.00
Summary
This research project is about understanding why some people are most susceptible to disease than others, by identifying genetic factors that influence the expression of genes that are important in disease. We will work with leaders in the field in Europe and the USA in an international research consortium to find genetic variants with an effect on gene expression and to link those genetic factors to disease. The project will provide new understanding about the biological basis of common disease ....This research project is about understanding why some people are most susceptible to disease than others, by identifying genetic factors that influence the expression of genes that are important in disease. We will work with leaders in the field in Europe and the USA in an international research consortium to find genetic variants with an effect on gene expression and to link those genetic factors to disease. The project will provide new understanding about the biological basis of common diseases.Read moreRead less
This study is aimed at identifying genetic variants that influence susceptibility to migraine. We plan to use DNA samples already collected from families with multiple migraine affected individuals and sequence a region on the X chromosome that has previously been identified as harbouring a migraine susceptibility gene. This project will identify gene(s) that contain variants contributing to migraine.
Development And Application Of A Mendelian Randomization Framework Aimed At Dissecting The Biological Basis Of Ankylosing Spondylitis And Other Complex Diseases
Funder
National Health and Medical Research Council
Funding Amount
$279,666.00
Summary
Our aim is to identify genes and biological molecules that cause a type of autoimmune arthritis called ankylosing spondylitis. Our approach involves finding combinations of genes that are related to biological molecules of interest and then testing to see whether the gene combination is also related to risk of disease. We hope that our strategy will lead to new drug treatments targeting the condition.