About one in eight known genetic disorders involve DNA alteration that activates a cellular quality control mechanism that disables the affected gene. This mechanism is more efficient in some individuals than others. It can influence disease outcomes and severity. We will engineer and apply tools and models to measure and manipulate this crucial cellular mechanism. This will allow us to predict disease severity as well as to intervene where a manipulation of this mechanism will be beneficial.
Identification Of The Conformation Dependant Targets Of Autoimmune Disease Linked Variation In Human Regulatory T Cells
Funder
National Health and Medical Research Council
Funding Amount
$1,001,815.00
Summary
Specialised immune cells called regulatory T cells act as the policemen of the immune system, preventing the immune system attacking itself, but still fighting infections. If these cells do not work properly, autoimmune diseases such as type 1 diabetes or IBD can arise, because of immune attack on normal body tissue by mistake. In order to explain how this goes wrong we need to carefully identify all of the gene interactions in these cells including interactions over long distances in the DNA.
Special Research Initiatives - Grant ID: SR0354675
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Australian Communications Research Network (ACoRN). Information and Communication Technology is a key contributor to national productivity and growth. ACoRN aims to stimulate creativity, innovation and breakthrough science, leading to technological advancement in telecommunications. The focus is on development of fundamental theories for application to emerging wired and wireless communications technologies. Specific objectives include consolidation of existing linkages; facilitation of multidis ....Australian Communications Research Network (ACoRN). Information and Communication Technology is a key contributor to national productivity and growth. ACoRN aims to stimulate creativity, innovation and breakthrough science, leading to technological advancement in telecommunications. The focus is on development of fundamental theories for application to emerging wired and wireless communications technologies. Specific objectives include consolidation of existing linkages; facilitation of multidisciplinary research; formation of new links; stimulation of commercial activity; improved post-graduate education; and increased International prominence. Our current vision involves a range of programs including: undergraduate occupational training, postgraduate internships, national and international visiting programs, and seed funding for collaborative proposals.Read moreRead less
MicroRNAs are small molecules that modulate the expression of most genes and so affect nearly every biological process and pathology although, they were only discovered in humans less than 10 years ago. The bottleneck in discovering the functions of miRNAs is in identifying their molecular targets, the majority of which remain unknown. We aim to comprehensively identify direct target genes of epithelial-specific microRNAs and to confirm a number of them by gene target validation approaches.
Role Of The MiR-200 Target Quaking In Alternative Splicing During EMT And Cancer Progression
Funder
National Health and Medical Research Council
Funding Amount
$443,160.00
Summary
The spread of cancer to other organs involves cancer cells changing to a more aggressive state and is a major cause of cancer related death. MicroRNAs are a class of genes that control whether cancer cells become more aggressive by regulating other genes. In this project we will examine the function of a new microRNA target which controls the cancer cell aggression. The outcome will be a better understanding of how cancers spread and the identification of new therapeutic targets.
ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the ....ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the core activities of the Network: Researcher Mobility, Workshops and Conferences, Postgraduate Education, and Knowledge Management Systems. The Network is expected to add significant value to pre-existing investments and raise the profile of Australian telecommunications research.Read moreRead less
Broadband to the bush: Polarization as a new resource in wireless cross-layer design. 'Broadband to the Bush' is a national priority - more than 1.6 million homes, small businesses and not-for-profit organizations in rural, regional, and remote Australia are set to benefit from broadband access to phone networks and the internet. The immediate challenges lie in overcoming poor download speeds and area coverage, as well as expensive access. This research will deliver cost and power-efficient re ....Broadband to the bush: Polarization as a new resource in wireless cross-layer design. 'Broadband to the Bush' is a national priority - more than 1.6 million homes, small businesses and not-for-profit organizations in rural, regional, and remote Australia are set to benefit from broadband access to phone networks and the internet. The immediate challenges lie in overcoming poor download speeds and area coverage, as well as expensive access. This research will deliver cost and power-efficient receiver architectures to provide end-user utility, and will train postgraduate researchers across traditional discipline boundaries in mathematics and engineering. The project represents an important contribution to frontier technologies in information and communications technology for building and transforming Australian industries.Read moreRead less
The migration of cancer cells (metastasis) is responsible for most cancer deaths. Central to this is dynamic organisation of the actin cytoskeleton _ an internal structure that provides cell shape and enables movement. We have identified a family of small molecules (called miR-200) that regulates this actin cytoskeleton through specifically downregulating various genes. We are investigating the nature of these genes and their role in cell motility _ an underlying pre-requisite of metastasis.
Incorporating network-level knowledge into Quality of Service control mechanisms for wireless LANs. Expansion of Wireless LANs as primary access technology for mobile computing devices has resulted in growing expectations of continuous area coverage and controlled Quality of Service. The work published to date defines QoS control mechanisms for a single WLAN cell, but fails to address challenges of multiple-cell networks. We aim at designing network-wide resource management mechanisms to dynamic ....Incorporating network-level knowledge into Quality of Service control mechanisms for wireless LANs. Expansion of Wireless LANs as primary access technology for mobile computing devices has resulted in growing expectations of continuous area coverage and controlled Quality of Service. The work published to date defines QoS control mechanisms for a single WLAN cell, but fails to address challenges of multiple-cell networks. We aim at designing network-wide resource management mechanisms to dynamically allocate resources to cells and users, taking into account user mobility and radio interference between multiple cells. Benefits from this research include competitive advantage to operators who will be able to differentiate service offerings and guarantee agreed QoS to their customers.Read moreRead less
Efficient Transmission Strategies for Cooperative Wireless Ad Hoc Networks. The contribution of information and communications technologies to the national economy has been widely recognized. It enables wealth creation, employment and exports, underpinning many innovation processes. Immediate project benefits will be: contribution to the knowledge base and fundamental capabilities in wireless communication; education of future Australian academic and industrial innovators; raising the internati ....Efficient Transmission Strategies for Cooperative Wireless Ad Hoc Networks. The contribution of information and communications technologies to the national economy has been widely recognized. It enables wealth creation, employment and exports, underpinning many innovation processes. Immediate project benefits will be: contribution to the knowledge base and fundamental capabilities in wireless communication; education of future Australian academic and industrial innovators; raising the international profile of Australian research in the area of information technology. The proposed research is in areas of great commercial interest, addressing new directions and technologies for future wireless networks. Applied development of the outcomes will lead to valuable intellectual property for commercial exploitation.Read moreRead less