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Genomic Approaches To Understanding Tasmanian Devil Facial Tumor Disease
Funder
National Health and Medical Research Council
Funding Amount
$210,855.00
Summary
Devil facial tumor disease (DFTD) is an emerging infectious disease affecting Tasmanian devils. DFTD is a transmissible cancer, and results in the growth of large tumors usually on the face and mouth of affected animals. DFTD has led to the collapse of the Tasmanian devil population, and there is concern that the disease will drive devils to extinction in the wild within the next 20 years. I propose to use new genome sequencing technologies to discover genes responsible for DFTD.
Genome-wide Association Studies Of Biomedical Traits And Endophenotypes For Complex Disease
Funder
National Health and Medical Research Council
Funding Amount
$295,804.00
Summary
The burden of common complex diseases, such as cardiovascular disease is substantial to the health care system. These diseases are caused by genes and environments as well as their interactions. The proposed project will identify genes affecting the susceptibility of individuals to complex diseases. Discovery of such genes will be important for their diagnosis, prevention and treatment and may serve as an important resource for future personalized medicine.
Combating Infectious Diseases: Eco-Epidemiology, Disease Mapping, And Travel Medicine
Funder
National Health and Medical Research Council
Funding Amount
$344,644.00
Summary
Infectious disease outbreaks are driven by complex interactions between humans, animals, vectors, and the environment. Globally, outbreaks have been increasing in frequency and magnitude, e.g. Ebola and SARS. There is an urgent need to improve public health intelligence by accurately identifying the causes, timing, and hotspots. This project will develop advanced modelling strategies for improving our understanding of outbreaks, and optimise public health interventions to protect human health.
The Mutational Landscape Of Melanoma In Adolescents And Young Adults
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Melanoma is the most common cause of cancer mortality in 20-34 year olds and many traditional treatments, chemotherapy and radiotherapy cause tremendous long-term damage to growing bodies. Fortunately new drugs that target the genetic mutations are proving effective. Unfortunately, the genomic mutation specific to young melanoma patients are unknown. This study aims to characterising the genomic mutations of young melanoma patients, leading to the discovery of innovative treatment options.
Hypoallergenic Proteins As Novel Immunotherapeutic Candidates For Food Allergy
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
The rate of food allergy has tripled over the past decade and is a leading cause of food related anaphylaxis in Australia. Allergen immunotherapy can help patients develop tolerance to the allergenic food. This research will investigate the potential of hypoallergenic derivatives of two major food allergens as novel desensitisation therapeutics, addressing an issue of significant importance to human health, paving the way for research on advanced therapeutics for paediatric food allergy.