Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics ....Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics for use in real world applications. The project has two aspects. First, relatively small directed cDNA-bead libraries will be compared to known low-density cDNA microarrays to validate the technique for utility in gene expression profiling. Secondly, large libraries containing short oligonucleotide sequences will be used for de novo sequencing of a complete transcriptome. Proof-of-concept in either case will pave the way for many genomic applications and catapult the technology to 'blockbuster' status.Read moreRead less
Novel Hybrid Inorganic Nanoparticles for Effective siRNA Delivery to Neurons. This project will lead to a more efficient and reliable drug delivery system to treat Huntington's disease. The insights and technology gained from this project will be directly applicable for many human diseases, both within and outside the central nervous system. This project will make a major contribution to the ARC's goal of maintaining good health and promises to significantly reduce the financial and psychologica ....Novel Hybrid Inorganic Nanoparticles for Effective siRNA Delivery to Neurons. This project will lead to a more efficient and reliable drug delivery system to treat Huntington's disease. The insights and technology gained from this project will be directly applicable for many human diseases, both within and outside the central nervous system. This project will make a major contribution to the ARC's goal of maintaining good health and promises to significantly reduce the financial and psychological burdens to patients' family and community. This project will encourage inter-disciplinary approaches to research and train highly skilled researchers both in neuroscience and nanobiotechnology to advance Australia's industrial competitiveness.Read moreRead less
Multi-scale Modelling and Simulation of Self-assembling Photonic Crystals. By using bandgaps and introduced defect states, photonic crystals provide the opportunities to shape and mould the flow of light. A success in fabricating 3D photonic crystals with complete bandgaps in a controllable and large-scale fashion will revolutionise the information & telecommunication industry. This ability will provide Australia with a significant niche opportunity at the leading edge of this frontier technolog ....Multi-scale Modelling and Simulation of Self-assembling Photonic Crystals. By using bandgaps and introduced defect states, photonic crystals provide the opportunities to shape and mould the flow of light. A success in fabricating 3D photonic crystals with complete bandgaps in a controllable and large-scale fashion will revolutionise the information & telecommunication industry. This ability will provide Australia with a significant niche opportunity at the leading edge of this frontier technology. It builds on Australia's established strength in material science, photonics, and information & communication technology. The mathematical models, simulation platform, and fabrication methods developed in this project will also be applicable to creating other highly-structured, functional materials.Read moreRead less
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less
Directed assembly and photoelectric properties of core-shell nanowire networks of PbSe-TiO2 heterostructures for high efficiency low-cost solar cells. The proposed program is aimed at studying numerous fundamental properties and phenomena of photoelectrochemical cells that have an important impact on environmentally friendly solutions to energy problems. Specifically, solar cells have a significant role in energy markets and in lessening CO2 emissions and other environmental impacts. Solar cell ....Directed assembly and photoelectric properties of core-shell nanowire networks of PbSe-TiO2 heterostructures for high efficiency low-cost solar cells. The proposed program is aimed at studying numerous fundamental properties and phenomena of photoelectrochemical cells that have an important impact on environmentally friendly solutions to energy problems. Specifically, solar cells have a significant role in energy markets and in lessening CO2 emissions and other environmental impacts. Solar cell technology, coupled with renewable energy sources, has the potential to provide a long-term solution to the energy crisis and the global warming threat. In addition, the strong team to be assembled will reach a leading position in this area of cutting edge technology. The outcomes will benefit Australian industries.Read moreRead less
Porous Silica-Based Nanocapsules for Targeted and Controlled Release of Biocides. The project will lead to significant advances in nanotechnology and agrichemical biocide applications. A highly efficient insect control technology will be developed, that will be cost-effective with the ability for targeted control and release of biocides. The encapsulation technology will reduce the total usage and costs of biocides thus benefit the environment in terms of reduced environment pollution and enhanc ....Porous Silica-Based Nanocapsules for Targeted and Controlled Release of Biocides. The project will lead to significant advances in nanotechnology and agrichemical biocide applications. A highly efficient insect control technology will be developed, that will be cost-effective with the ability for targeted control and release of biocides. The encapsulation technology will reduce the total usage and costs of biocides thus benefit the environment in terms of reduced environment pollution and enhanced ecological safety.Read moreRead less
Characterisation and Modelling of Nanostructured Soft Magnetic Materials for Advanced Electromagnetic Applications. This project bridges the gap between nanomagnetic materials and practical applications. The knowledge generated and the international collaborations with world class scientists established through this cutting-edge research project will strengthen the leading status of Australia in the field of nanoscience and nanotechnology. The research outcomes will stimulate the growth of world ....Characterisation and Modelling of Nanostructured Soft Magnetic Materials for Advanced Electromagnetic Applications. This project bridges the gap between nanomagnetic materials and practical applications. The knowledge generated and the international collaborations with world class scientists established through this cutting-edge research project will strengthen the leading status of Australia in the field of nanoscience and nanotechnology. The research outcomes will stimulate the growth of world class Australian industries and hence the national economy through the commercial manufacturing of hi-tech nanomagnetic materials and innovative smart devices and systems. High quality PhD and honours project students will be trained.Read moreRead less
Self-organised complex ionised gas systems for ordered nanometre-scale assemblies. This proposal is to develop the physical principles of nano-scale assembly processes in complex plasmas. Novel approaches for tailoring the plasma-grown building blocks and controllable deposition of ordered nanoparticle arrays on nanopatterned solids are targeted. The fundamentals of the multi-scale dynamic processes will be elucidated and existing techniques for developing new materials and electronic/photonic d ....Self-organised complex ionised gas systems for ordered nanometre-scale assemblies. This proposal is to develop the physical principles of nano-scale assembly processes in complex plasmas. Novel approaches for tailoring the plasma-grown building blocks and controllable deposition of ordered nanoparticle arrays on nanopatterned solids are targeted. The fundamentals of the multi-scale dynamic processes will be elucidated and existing techniques for developing new materials and electronic/photonic devices will be advanced. The expected outcomes are highly relevant for the nano-materials and optoelectronic technologies, rapidly emerging areas of high-tech industries worldwide.Read moreRead less
CNTs-modified polymer composites for tribological applications. The growth of the Australian economy relies on continuous improvements in all sectors of production, manufacturing, operation and management where tribology is playing a significant role. System failure relevant to wear and friction over years and its impact on the Australian economy have continued to be a challenge for the community in the new century. The project is at the forefront of materials research, and the outcomes will pro ....CNTs-modified polymer composites for tribological applications. The growth of the Australian economy relies on continuous improvements in all sectors of production, manufacturing, operation and management where tribology is playing a significant role. System failure relevant to wear and friction over years and its impact on the Australian economy have continued to be a challenge for the community in the new century. The project is at the forefront of materials research, and the outcomes will provide (1) novel technical ways to optimise tribological performance of industrial contacting components, and (2) development of new wear resistant materials. The project will give Australia a competitive edge in the advances of tribology and nanotechnologyRead moreRead less