Integrating Immunity And Genetics In Follicular Lymphoma To Establish A Prognostic Score Fit For The Modern Era
Funder
National Health and Medical Research Council
Funding Amount
$1,377,174.00
Summary
Follicular lymphoma (FL) is divided into early and advanced stages. Early stage FL is frequently cured, but there is no way to identify who will be cured and who won't. By contrast advanced stage FL is incurable. Our unique access to well-annotated clinical trial and population based cohorts allows us to perform a detailed biological comparison of early and advanced FL, to gain a deeper understanding of the impediments to eradicating the disease, and to predict outcome to conventional therapy.
Genome-wide Association Studies Of Biomedical Traits And Endophenotypes For Complex Disease
Funder
National Health and Medical Research Council
Funding Amount
$295,804.00
Summary
The burden of common complex diseases, such as cardiovascular disease is substantial to the health care system. These diseases are caused by genes and environments as well as their interactions. The proposed project will identify genes affecting the susceptibility of individuals to complex diseases. Discovery of such genes will be important for their diagnosis, prevention and treatment and may serve as an important resource for future personalized medicine.
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Post-GWAS Functional Characterisation Of Breast Cancer Susceptibility Loci
Funder
National Health and Medical Research Council
Funding Amount
$764,632.00
Summary
Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known genes, suggesting that regulatory DNA sequences are responsible for the associated risk. The aim of this proposal is to identify and characterise these DNA sequences. Understanding how sequences variations in these regions contribute to breast cancer will provide novel avenues for therapy.
High-throughput Identification And Evaluation Of New Breast Cancer Genes From GWAS.
Funder
National Health and Medical Research Council
Funding Amount
$841,075.00
Summary
Recent studies have identified DNA markers within the human genome that are associated with an increased risk of breast cancer. Most of these markers are located in noncoding regions, therefore the key genes driving risk are not known. This proposal will identify the target genes at all breast cancer risk regions and assess how specific markers affect disease risk. Understanding how DNA variation contributes to breast cancer will provide new avenues for prevention or treatment.
Discovery Early Career Researcher Award - Grant ID: DE120100163
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Modelling and simulation of instabilities in unsaturated soils due to wetting. Ground instabilities due to wetting are a critical issue that will be investigated through this project via the development of risk assessment tools. A rational engineering approach and calculation framework will be developed in order to predict failures and facilitate the design of new safer structures.
Stochastic modelling of spatiotemporal nonlinear diffusion processes with multifractal characteristics. This research is relevant to solute transport and plume evolution in heterogeneous media. Detailed modelling of these processes is computer-intensive, while the diffusion models of this project offer a more economical alternative. Our study will also benefit the research on the salinity problem. Excessive demand for irrigation water to support agricultural production has stretched freshwater a ....Stochastic modelling of spatiotemporal nonlinear diffusion processes with multifractal characteristics. This research is relevant to solute transport and plume evolution in heterogeneous media. Detailed modelling of these processes is computer-intensive, while the diffusion models of this project offer a more economical alternative. Our study will also benefit the research on the salinity problem. Excessive demand for irrigation water to support agricultural production has stretched freshwater aquifers beyond their long-term yield. Large areas of land have been lost to saltwater intrusion. This proposal will provide suitable tools to predict the level and movement of saltwater in the aquifers. Application to the development of management strategies would bring direct benefit to coastal areas where salinity is a sustainability issue.Read moreRead less
Stochastic modelling and analysis of spatio-temporal processes with fractal characteristics. Interest has grown in recent years on the derivation of fractal models to represent certain physical phenomena such as diffusion and transport in porous media, oceanic and atmospheric turbulence, climatology, etc. This project focuses on the phenomenon of diffusion on domains with multifractal geometry. Recent advances in harmonic analysis on fractals and our own development of fractional generalized ran ....Stochastic modelling and analysis of spatio-temporal processes with fractal characteristics. Interest has grown in recent years on the derivation of fractal models to represent certain physical phenomena such as diffusion and transport in porous media, oceanic and atmospheric turbulence, climatology, etc. This project focuses on the phenomenon of diffusion on domains with multifractal geometry. Recent advances in harmonic analysis on fractals and our own development of fractional generalized random fields allow us to formulate a comprehensive program to tackle some key problems including modeling, processing and statistical estimation of fractional diffusion. Advances made in this program will in turn benefit the developments in related scientific fields.Read moreRead less
Regulation of the EphA3 receptor tyrosine kinase in vertebrate development. The Eph/ephrin system has a critical role in normal embryonic development. Amongst vertebrates, the EphA3 gene is one of the most highly conserved genes in this system with critical roles in development of the visual system and in other developmental processes. Understanding how this gene is regulated will help us to understand the critical role of EphA3 in the basic biology of humans and other animals. This knowledge ma ....Regulation of the EphA3 receptor tyrosine kinase in vertebrate development. The Eph/ephrin system has a critical role in normal embryonic development. Amongst vertebrates, the EphA3 gene is one of the most highly conserved genes in this system with critical roles in development of the visual system and in other developmental processes. Understanding how this gene is regulated will help us to understand the critical role of EphA3 in the basic biology of humans and other animals. This knowledge may also shed light on the basis of congenital abnormalities and other pathological processes and possibly help us to understand how to prevent or treat these conditions.Read moreRead less