Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Industrial Transformation Training Centres - Grant ID: IC170100032
Funder
Australian Research Council
Funding Amount
$4,272,072.00
Summary
ARC Training Centre in Fire Retardant Materials and Safety Technologies. The ARC Training Centre in Fire Retardant Materials and Safety Technologies aims to train a cohort of industry-focused researchers to improve the fire safety of lightweight materials and structures and fire protection systems. The Training Centre expects to create knowledge on novel green and durable fire retardant materials, advanced fire models for urban and built environment, fire suppression technologies, and new flamma ....ARC Training Centre in Fire Retardant Materials and Safety Technologies. The ARC Training Centre in Fire Retardant Materials and Safety Technologies aims to train a cohort of industry-focused researchers to improve the fire safety of lightweight materials and structures and fire protection systems. The Training Centre expects to create knowledge on novel green and durable fire retardant materials, advanced fire models for urban and built environment, fire suppression technologies, and new flammability tests for compliance with fire safety regulatory standards. An expected outcome of this Training Centre is to accelerate the transformation of Australia’s industries in fire retardant materials, products and engineering services.Read moreRead less
Enabling low greenhouse gas emissions from road vehicles through the proper use of alternative fuels. A major increase in alternative transport fuel use appears necessary in our response to the challenges of climate change and energy security. This proposal will advance our fundamental understanding of key aspects of the combustion of particular alternative fuels, thus enabling proper engine design and so maximising greenhouse and energy security benefits. Further, the Australian automotive indu ....Enabling low greenhouse gas emissions from road vehicles through the proper use of alternative fuels. A major increase in alternative transport fuel use appears necessary in our response to the challenges of climate change and energy security. This proposal will advance our fundamental understanding of key aspects of the combustion of particular alternative fuels, thus enabling proper engine design and so maximising greenhouse and energy security benefits. Further, the Australian automotive industry is a major employer and exporter, and needs to develop and/or maintain international leadership in low emission technologies to ensure its long term viability. This proposal builds a consortium of local organisations with common interests, thus helping local industry respond to several, significant challenges that they presently face.Read moreRead less
Thermal transport in multi-phase flows for concentrating solar applications. This project seeks to advance the field of heat transfer in high-temperature systems involving liquid metals, with emphasis on energy storage and solar power technologies. The concept couples a tubular sodium boiler with a sodium chloride phase-change storage system for continuous energy supply. Sodium chloride is low cost and has a melting temperature suitable for a wide range of industrial processes. The project plans ....Thermal transport in multi-phase flows for concentrating solar applications. This project seeks to advance the field of heat transfer in high-temperature systems involving liquid metals, with emphasis on energy storage and solar power technologies. The concept couples a tubular sodium boiler with a sodium chloride phase-change storage system for continuous energy supply. Sodium chloride is low cost and has a melting temperature suitable for a wide range of industrial processes. The project plans to address the challenge of sodium stability in highly irradiated tubes by investigating mass, momentum, energy and radiative transport in liquid metals. It is intended that this will inform the design and testing of novel sodium boilers to provide stable and isothermal process heat for continuous or on-demand production of power, chemical fuels and commodities.Read moreRead less
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Understanding the Origin and Development of Extreme and Mega Bushfires. Extreme and megafires result in significant damage to property and infrastructure and are associated with large suppression costs. These events form when separate fires Merge. Their increase occurrence in recent seasons highlights the importance of developing tools and technologies that better predict extreme events to aid fire response and inform strategies for greater resilience. This project combines fire field experiment ....Understanding the Origin and Development of Extreme and Mega Bushfires. Extreme and megafires result in significant damage to property and infrastructure and are associated with large suppression costs. These events form when separate fires Merge. Their increase occurrence in recent seasons highlights the importance of developing tools and technologies that better predict extreme events to aid fire response and inform strategies for greater resilience. This project combines fire field experiments with computer modelling to determine factors driving extreme fire development, and develop new knowledge and models. These enable better prediction of active fires, enhance the knowledge base of fire managers for critical decision making and to improve risk modelling and mitigation planning for fire-prone communities.Read moreRead less
Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. Inte ....Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. International attention has already resulted in genome characterization of Australian icons (wallaby, Tasmanian devil and platypus), more research on these, and other Australian animals, will further highlight the importance of Australian fauna and impact positively on our scientific profile.Read moreRead less
Origin and Evolution of Mammalian Dosage Compensation. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional comparative genomics in Australia, with the research priority of 'Frontier Technologies for Building and Transforming Australian Industries' and priority goals in 'Breakthrough Science and Frontier Technologies'. This project addresses fundamental questions about the evolution of mammalian X-chromosome inactivation, of importance as a mo ....Origin and Evolution of Mammalian Dosage Compensation. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional comparative genomics in Australia, with the research priority of 'Frontier Technologies for Building and Transforming Australian Industries' and priority goals in 'Breakthrough Science and Frontier Technologies'. This project addresses fundamental questions about the evolution of mammalian X-chromosome inactivation, of importance as a model for epigenetic change, and sex chromosomes, which has engaged some of the greatest genetic minds over nearly a century. Therefore my results will attract wide international interest and impact positively on Australia's scientific profile, and further highlight the importance of Australian mammals.Read moreRead less
ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit ne ....ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit new cell technologies. The Centre will build critical mass and national focus in bioinformatics to generate the human capital and intellectual property that Australia needs to compete in advanced bioscience and biotechnology.Read moreRead less
The role of neutral amino acid transport in normal physiology. Future benefits of these studies include the Promotion and Maintenance of Good Health achieved by providing: (1) a better understanding of brain and balance disorders; (2) insights into the damaging effects of the sun and; (3) existing neonatal screening programmes for Hartnup disorder with greater scientific foundation regarding the implications of inheriting this condition, including dietary advce. We will be able to provide Austr ....The role of neutral amino acid transport in normal physiology. Future benefits of these studies include the Promotion and Maintenance of Good Health achieved by providing: (1) a better understanding of brain and balance disorders; (2) insights into the damaging effects of the sun and; (3) existing neonatal screening programmes for Hartnup disorder with greater scientific foundation regarding the implications of inheriting this condition, including dietary advce. We will be able to provide Australians who inherit Hartnup disorder with a better understanding of this disease by enabling individuals and families to make choices that lead to healthy, productive and fulfilling lives.Read moreRead less