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Mechanisms Of Gender Differences In Genetic Aortopathy
Funder
National Health and Medical Research Council
Funding Amount
$122,686.00
Summary
This project will investigate the molecular mechanisms that underly the gender differences in phenotypic expression in young adults with genetic aortopathy.
Targeting PI3K-regulated MicroRNAs To Treat Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$532,593.00
Summary
Current therapeutics largely delay heart failure progression rather than regressing it. New therapeutic strategies with the capability of improving function of the failing heart are thus greatly needed. The primary goal of this study is to determine whether novel regulatory genes can enhance cardiac function in a setting of heart failure. Ultimately, technologies that target these genes may lead to innovative pharmacotherapies in the clinical management of heart failure.
The adult heart has an extremely limited capacity for regeneration. In contrast, I recently discovered that the newborn heart can completely regenerate following a heart attack. How and why the heart loses this regenerative capacity after birth is not known. This Fellowship aims to unravel the genetic circuits that govern cardiac regenerative capacity. The proposed research program will develop novel therapies for heart regeneration through molecular targeting of regulatory RNA molecules.
Regulating Gene Expression Changes In Cardiac Hypertrophy
Funder
National Health and Medical Research Council
Funding Amount
$690,754.00
Summary
Following the success in decoding human genome, i.e. DNA sequence, a major task is to understand how the activity of genes with consequent changes in respective proteins. As proteins are an important component for cell structure and function, such changes in quantity and quality of proteins will play a pivotal role to affect disease development and progression.
Inadequately controlled blood pressure remains the leading cause of death world wide despite the availability of numerous effective drugs. We have successfully pioneered a catheter-based approach using radiofrequency-energy to disrupt renal nerves and lower blood pressure in patients with resistance to conventional drug treatment. We now aim to test the role of this ground-breaking technology as a potential cure (blood pressure control without antihypertensive medication) for hypertension.
Using Nkx2-5 Knock-in Mouse Models To Understand Complex Cardiac Diseases
Funder
National Health and Medical Research Council
Funding Amount
$611,340.00
Summary
The most common cause of postnatal mortality is heart defects associated with mutation in transcriptional factors, of which NKX2-5 is the master gene. NKX2-5 is also involved in cardiac dysfunction in adults. We developed a unique mouse genetic approach that mimics human disease to study the mechanism behind this gene function. Our work paves the way to more efficient forecast, counseling and treatment strategies, reducing the socio-economic burden of congenital heart disease our community.
Contribution Of The Central Nervous System To Peripheral Neural Control In Obesity And Diabetes.
Funder
National Health and Medical Research Council
Funding Amount
$454,691.00
Summary
Obesity and diabetes are becoming major worldwide public health problems. A characteristic of human obese diabetes is a marked increase in sympathetic nerve activity to the kidneys and to the muscle. The cause of this overactivity is unknown, but undoubtedly involves the central nervous system. Within the brain are a select group of regions that are able to directly influence the activation of the sympathetic nervous system. We suspect these areas to play a critical role in the overactivity of t ....Obesity and diabetes are becoming major worldwide public health problems. A characteristic of human obese diabetes is a marked increase in sympathetic nerve activity to the kidneys and to the muscle. The cause of this overactivity is unknown, but undoubtedly involves the central nervous system. Within the brain are a select group of regions that are able to directly influence the activation of the sympathetic nervous system. We suspect these areas to play a critical role in the overactivity of the sympathetic nerve activity in obese diabetics. Indeed, we believe that there are specific chemical messengers in these select brain areas that are normally finely balanced. In obesity - diabetes, this balance is disturbed. Finally, we hypothesise that exercise, which is known to have beneficial effects for obesity - diabetes, restores the balance of the neurochemicals and this contributes to the positive outcomes of exercise.Read moreRead less
Protective Role Of The Depressor Arm Of The Renin-angiotensin System During Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$633,384.00
Summary
The motivation for unveiling the normal hormonal and molecular mechanisms involved in the extraordinary vasodilatation associated with pregnancy is that understanding these fundamental processes may provide novel insights into the pathophysiology of preeclampsia and intrauterine growth restriction, as well as potential therapeutic strategies for not only the treatment of these pregnancy specific conditions but also cardiovascular and renal diseases in non-pregnant women and men.
Therapeutic Silencing Of Egr-1 By Novel Catalytic Oligodeoxynucleotides For The Treatment Of Acute Myocardial Infarction
Funder
National Health and Medical Research Council
Funding Amount
$384,353.00
Summary
Heart attack remains a major health problem. We have identified a gene in the heart which is turned on in the first few hours of a heart attack. We have shown in principle that switching this gene off using a novel synthetic drug, reduces heart attack size. Our project assesses the long term effects of this drug on the heart using state of the art imaging when the the drug is administered in a clinically relevant manner. This study may faciliate a new treatment approach for this condition.