The Australian Research Data Commons (ARDC) invites you to participate in a short survey about your
interaction with the ARDC and use of our national research infrastructure and services. The survey will take
approximately 5 minutes and is anonymous. It’s open to anyone who uses our digital research infrastructure
services including Reasearch Link Australia.
We will use the information you provide to improve the national research infrastructure and services we
deliver and to report on user satisfaction to the Australian Government’s National Collaborative Research
Infrastructure Strategy (NCRIS) program.
Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
Understanding the vesicle release mechanisms that regulate peripheral serotonin levels. The purpose of this project is to understand how serotonin is released into the circulation from specialised cells within the gut. As circulating serotonin controls multiple biological systems within the gut and throughout the body, the outcomes of this project will further understandings of the systems controlling essential bodily functions.
Identification of novel antigens for vaccination and immunotherapy against the human gastric pathogen, Helicobacter pylori. The bacterium Helicobacter pylori is a significant human pathogen which infects the stomach where it is the major cause of stomach and duodenal ulcers, plus two types of cancer. This project proposes to utilise a novel strategy to identify potential vaccine targets on the bacterial surface with the aim to develop an effective vaccine against this organism. Such a vaccine wo ....Identification of novel antigens for vaccination and immunotherapy against the human gastric pathogen, Helicobacter pylori. The bacterium Helicobacter pylori is a significant human pathogen which infects the stomach where it is the major cause of stomach and duodenal ulcers, plus two types of cancer. This project proposes to utilise a novel strategy to identify potential vaccine targets on the bacterial surface with the aim to develop an effective vaccine against this organism. Such a vaccine would protect against the development of stomach cancer, hence saving lives, plus significantly reduce the incidence of stomach ulcers, thereby reducing suffering of individuals and providing financial benefits to employers.Read moreRead less
Reg growth factors in gastric regeneration and disease. This project will obtain a more detailed knowledge of the role that growth factors play in helping the lining of the stomach repair itself after damage caused by disease. Growth factors may also play a role in causing stomach cancer. To do this we will examine the expression of growth factors in number of stomach diseases and cancer and assay the ability of growth factors to promote the growth of stomach cells.
This work is that it will co ....Reg growth factors in gastric regeneration and disease. This project will obtain a more detailed knowledge of the role that growth factors play in helping the lining of the stomach repair itself after damage caused by disease. Growth factors may also play a role in causing stomach cancer. To do this we will examine the expression of growth factors in number of stomach diseases and cancer and assay the ability of growth factors to promote the growth of stomach cells.
This work is that it will contribute to our knowledge of how cell growth in the stomach is controlled under normal circumstances and in the very common pathological conditions of tissue damage, inflammation and cancer. It may also help us understand how inflammation can in some circumstances lead to cancer.Read moreRead less
Defining how serotonin regulates gut motility. This project aims to deepen knowledge of gastrointestinal physiology, and reveal the mechanisms by which the major gastrointestinal signalling molecule, serotonin, regulates gut peristalsis. Almost all of the serotonin in our body is made in the gastrointestinal tract where it controls many functions, including how our gut wall contracts during peristalsis. Proper control of gut peristalsis and the transit of material through our bowel is important ....Defining how serotonin regulates gut motility. This project aims to deepen knowledge of gastrointestinal physiology, and reveal the mechanisms by which the major gastrointestinal signalling molecule, serotonin, regulates gut peristalsis. Almost all of the serotonin in our body is made in the gastrointestinal tract where it controls many functions, including how our gut wall contracts during peristalsis. Proper control of gut peristalsis and the transit of material through our bowel is important for our health. This project expects to define how serotonin controls peristalsis, where in the bowel this serotonin comes from, how serotonin communicates with the nervous system in our gastrointestinal tract, and how the cells that synthesise gut serotonin respond to contraction to trigger the secretion of serotonin.Read moreRead less
Gastrointestinal parasites and their diagnosis. Gastrointestinal disease such as diarrhoea, abdominal pain and irritable bowel syndrome are common in the Australian population and there are a wide variety of causes, including potentially parasites. The parasite Dientamoeba fragilis has, until recently, been overlooked as a cause of human disease, but recent studies have confirmed its role as a pathogen. This project seeks to improve the diagnosis of this organism in faeces and this development ....Gastrointestinal parasites and their diagnosis. Gastrointestinal disease such as diarrhoea, abdominal pain and irritable bowel syndrome are common in the Australian population and there are a wide variety of causes, including potentially parasites. The parasite Dientamoeba fragilis has, until recently, been overlooked as a cause of human disease, but recent studies have confirmed its role as a pathogen. This project seeks to improve the diagnosis of this organism in faeces and this development will allow effective treatment to be used in patients thereby ameliorating disease.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101807
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Fat sensing in the oral cavity and gastrointestinal tract: role in the regulation of gastrointestinal function and energy intake in health and obesity. This project will determine whether a reduced capacity to sense, or taste, the presence of fats in the oral cavity and the gastrointestinal tract diminishes the effects of fat on those aspects of gut function that regulate appetite and suppress energy intake. The project will, accordingly, provide important insights into the pathophysiology of ob ....Fat sensing in the oral cavity and gastrointestinal tract: role in the regulation of gastrointestinal function and energy intake in health and obesity. This project will determine whether a reduced capacity to sense, or taste, the presence of fats in the oral cavity and the gastrointestinal tract diminishes the effects of fat on those aspects of gut function that regulate appetite and suppress energy intake. The project will, accordingly, provide important insights into the pathophysiology of obesity.Read moreRead less
New uses for milk-derived products for eradication of Helicobacter pylori infection and gastro-intestinal site-specific delivery of active agents. Helicobacter pylori is the most significant bacterial pathogen in the world, infecting 50% globally. Current treatments are inducing rapid antibiotic resistance and are thus becoming increasingly less effective. The infection is acquired in childhood and new methods to prevent and/or treat the infection, minimising acquisition of antibiotic resistance ....New uses for milk-derived products for eradication of Helicobacter pylori infection and gastro-intestinal site-specific delivery of active agents. Helicobacter pylori is the most significant bacterial pathogen in the world, infecting 50% globally. Current treatments are inducing rapid antibiotic resistance and are thus becoming increasingly less effective. The infection is acquired in childhood and new methods to prevent and/or treat the infection, minimising acquisition of antibiotic resistance are urgently required. This project seeks to develop new ways of doing this that combine novel antibacterials with techniques to deliver them (and monitor this delivery) as well as modify the complex protective habitat in the stomach.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100261
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Understanding interactions between gut epithelial stem cells and neurons. This project aims to investigate the interaction between gut neurons and the epithelial stem cell compartment, as well as the relationship between age-related loss of enteric neurons and changes in gut epithelial stem cells. This project will include novel co-culturing of organoids and enteric neurospheres, which will identify mechanisms by which nerves influence the epithelia. The outcome of the project will be a better u ....Understanding interactions between gut epithelial stem cells and neurons. This project aims to investigate the interaction between gut neurons and the epithelial stem cell compartment, as well as the relationship between age-related loss of enteric neurons and changes in gut epithelial stem cells. This project will include novel co-culturing of organoids and enteric neurospheres, which will identify mechanisms by which nerves influence the epithelia. The outcome of the project will be a better understanding of the biology of the body’s most highly proliferative, long-lived stem cells, intestinal epithelial stem cells. This could have significant long term impact on the quality of life in an ageing population.Read moreRead less
Studies in cancer control. As life expectancy in Australia (and throughout the world) continues to rise, so will the burden of cancer escalate. Treating cancer after diagnosis is costly, and in many instances, unsuccessful. Preventive strategies promise to reduce the future cancer burden, yet our knowledge in this arena is limited by the lack of credible research as to what works and what does not. This application addresses this gap directly by conducting research into the control of two cancer ....Studies in cancer control. As life expectancy in Australia (and throughout the world) continues to rise, so will the burden of cancer escalate. Treating cancer after diagnosis is costly, and in many instances, unsuccessful. Preventive strategies promise to reduce the future cancer burden, yet our knowledge in this arena is limited by the lack of credible research as to what works and what does not. This application addresses this gap directly by conducting research into the control of two cancers which exact a growing toll in Australia and elsewhere. The work seeks to identify and understand the causal pathways to cancer, and then use this information to devise evidence-based strategies for cancer control.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100223
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Characterisation of visceral afferent spinal cord pathways. Sensory nerves in the gut wall are key mediators of chronic visceral pain. This project will characterise how sensory nerves supplying the bowel connect to the spinal cord and the spinal circuits mediating pain perception, providing information to identify sensory pathways underlying visceral pain.