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A Novel Strategy For The Early Diagnosis Of Cows Milk Protein Allergy In Infants.
Funder
National Health and Medical Research Council
Funding Amount
$607,764.00
Summary
Infantile Cow's Milk Protein Allergy (CMPA) is becoming increasingly more common. Symptoms due to CMPA (feeding difficulties, feed refusal, vomiting, crying and irritability) are clinically indistinguishable from reflux disease, leading to unnecessary anti-reflux treatments and delaying appropriate therapy. By using a state-of-the art system which more easily differentiates symptoms due to reflux disease from those due to CMPA, this project will improve the speed and accuracy of diagnosis.
Barrett's oesophagus (BO) is a condition that arises in some patients with chronic reflux (heartburn) and increases the risk of developing cancer of the oesophagus. However, the exact mechanisms involved in its development are unknown. This project aims to investigate how a protein called sonic hedgehog might be involved using novel cell culturing techniques that allow us to model the growth of oesophageal tissue in the laboratory. This could lead to development of new therapies for treating BO.
In Vivo Models For Understanding The Cellular And Molecular Pathogenesis Of Barrett's Oesophagus
Funder
National Health and Medical Research Council
Funding Amount
$283,767.00
Summary
The incidence of oesophageal adenocarcinoma, a malignancy that is almost invariably fatal, has doubled in recent years and continues to increase at an alarming rate. Oesophageal adenocarcinoma arises from Barrett's oesophagus, a premalignant condition that effects up to 2% of the population. In Barrett's, the normal cells of the oesophageal lining are changed to become more like cells that line the intestine. We have developed novel 3-dimensional cell culture models that allow us to reproduce th ....The incidence of oesophageal adenocarcinoma, a malignancy that is almost invariably fatal, has doubled in recent years and continues to increase at an alarming rate. Oesophageal adenocarcinoma arises from Barrett's oesophagus, a premalignant condition that effects up to 2% of the population. In Barrett's, the normal cells of the oesophageal lining are changed to become more like cells that line the intestine. We have developed novel 3-dimensional cell culture models that allow us to reproduce the normal layered structure of the human oesophageal lining in the laboratory and we propose to use these models to address key issues in the biology of Barrett's oesophagus. In aim 1, we wish to determine if the cells in patients with Barrett's have been permanently, or only transiently, altered and to understand the role of gastric acid- bile and accessory cells in this transformation. In aim 2 we will look more closely at the molecular changes that drive the cellular transformation characteristic of Barrett's. We will do this by manipulating the expression of selected genes in human oesophageal cells and assessing the effects of these genes on cell growth and differentiation using our cell culture models. The results of these studies will pave the way for the design of appropriate clinical strategies to treat Barrett's oesophagus and prevent the progression of this premalignant condition to oesophageal adenocarcinoma.Read moreRead less
Blood Serum MicroRNA Biomarkers For Oesophageal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$495,433.00
Summary
Oesophageal adenocarcinoma (OAC) is the 6th commonest cause of cancer deaths in the Western World, and is increasing in incidence. In Australia most patients present late and require risky treatments with a low cure rate. There is a big difference in survival between individuals presenting early vs. late. Better methods to detect cancer early or detect pre-cancer will improve outcomes. Our research will develop a blood test for identifying individuals with early OAC to allow earlier treatment.
Endoscopic Diagnosis And Therapy: The Frontier Of Minimally Invasive Patient Care.
Funder
National Health and Medical Research Council
Funding Amount
$344,644.00
Summary
Minimally invasive diagnosis and treatment is a rapidly developing field, and has potential to significantly improve patient management and health care utilization. This research will apply endoscopic innovations to diagnose and treat early oesophageal and pancreatic cancer, with the aim to improve survival and quality of life. The research will also develop capacity to treat oesophageal motility disorders with minimally invasive endoscopic resection techniques.