Novel Actions Of Beta-adrenoceptor Antagonists: Implications For The Treatment Of Cardiac Failure
Funder
National Health and Medical Research Council
Funding Amount
$142,630.00
Summary
Almost 2-3 of drugs on the market act on G protein-coupled receptors, and many are antagonists that block receptors. Antagonists were seen as inert compounds that prevent access of natural neurotransmitters or hormones, but recent studies indicate distinct actions. We believe that atypical effects of beta-adrenergic antagonists may explain their usefulness in treating cardiac failure. We seek to understand the process and develop assays to aid the development of new drugs for cardiac failure.