Novel Selective Anti-platelet And Clot-specific Anticoagulant Strategies Targeting Conformational States Of GPIIb/IIIa
Funder
National Health and Medical Research Council
Funding Amount
$496,517.00
Summary
The inhibition of platelets and the inhibition of coagulation factors are among the most widely used drugs in medicine and provide major benefits for numerous patients. Prevention and treatment of thrombosis, emboli, stroke and heart attack are examples of the many diseases where anti-platelet and anticoagulant drugs are administered. However, the downsides of these drugs are bleeding complications, which can result in death or disability. The consequences of these drug-associated bleeding compl ....The inhibition of platelets and the inhibition of coagulation factors are among the most widely used drugs in medicine and provide major benefits for numerous patients. Prevention and treatment of thrombosis, emboli, stroke and heart attack are examples of the many diseases where anti-platelet and anticoagulant drugs are administered. However, the downsides of these drugs are bleeding complications, which can result in death or disability. The consequences of these drug-associated bleeding complications are also a major financal burden for our health care system. Thus, progress towards therapeutic strategies with less bleeding complications is highly sought-after. The proposed project aims to generate new antibody-based agents for platelet inhibition. One group of these agents do only block platelets when they are activated. Furthermore, these agents allow an enrichment of potent inhibitors of coagulation factors at the site of the clot. Thus, these inhibitors should predominatly act at the site where they are needed. At the same time the overall concentration of inhibitors of coagulation factors can be kept low and the functions of non-activated platelet can be left intact. Overall, the proposed project aims for the development of novel anti-platelet and anticoagulant strategies with high anti-thrombotic efficacy and low bleeding risks.Read moreRead less
Trial Of Structured Support To Enhance The Role Of Non-GP Staff In Chronic Disease Management In General Practice
Funder
National Health and Medical Research Council
Funding Amount
$780,625.00
Summary
Chronic disease presents a significant burden to individuals and the health care system , contributing to both an increasing proportion of the work of primary health care practitioners and to health expenditure. A number of interventions have been shown to result in sustained improvement of health outcomes for people with chronic diseases, including: more effective use of non-physician providers of care and nurse case management; integration of self-management support programs with guideline bas ....Chronic disease presents a significant burden to individuals and the health care system , contributing to both an increasing proportion of the work of primary health care practitioners and to health expenditure. A number of interventions have been shown to result in sustained improvement of health outcomes for people with chronic diseases, including: more effective use of non-physician providers of care and nurse case management; integration of self-management support programs with guideline based treatment plans; more intensive follow up and registries that provide reminders and feedback. While some of these approaches have been pursued within the Coordinated Care Trials and the Enhanced Primary Care (EPC) program in Australia, the role of non medical staff within general practice in chronic disease care has not been systematically investigated. In 2001 the Commonwealth introduced a number of initiatives to support better quality of care for diabetes and asthma in general practice and $104.2 million over four years was provided for general practices in areas of high workforce pressure to employ more Nurses. The roles of the Practice Manager and Receptionist have received much less attention. They include faclitating access to care, supporting the delivery of quality clinical care by the practitioners through the provision of expert management services (primarily information technology, staff, financial and facilities management) to the practice. With recent government initiatives expanding the role of general practice in Australia, effective management structures and processes within general practices are vital. Non-GP general practice staff may be the means by which more effective chronic disease management can be achieved at a time of increasing workforce pressure. This project aims to evaluate the impact of a program in which non-GP staff are trained and facilitated to be involved in the management of patients with chronic disease.Read moreRead less
Knowledge to enhance Science Teaching and Learning: Pursuing scholarship through explicitly enacting expert science teachers' pedagogical content knowledge. This research will enhance understandings of science teaching and learning allowing science teachers to share their knowledge in meaningful ways. In teacher preparation this will be particularly valuable by 'fast-tracking' learning about teaching science and minimize the process of the next generation of teachers feeling as though they are r ....Knowledge to enhance Science Teaching and Learning: Pursuing scholarship through explicitly enacting expert science teachers' pedagogical content knowledge. This research will enhance understandings of science teaching and learning allowing science teachers to share their knowledge in meaningful ways. In teacher preparation this will be particularly valuable by 'fast-tracking' learning about teaching science and minimize the process of the next generation of teachers feeling as though they are rediscovering that which is already known by experienced teachers of science. In articulating science teachers' knowledge, enhanced valuing their knowledge and skills of practice will occur. Such outcomes will place understanding of science teaching and learning at the forefront of teacher professionalism and positively impact work on professional standards in teaching.Read moreRead less
Engaging science students' hearts and minds: Researching science teachers' professional learning in the development of contemporary understandings of scientific literacy. This project will develop, support and value the work of science teachers in developing students' scientific literacy and share the subsequent knowledge gains in the educational community to positively advance quality teaching and learning in school science. Improving science teaching and learning hinges on offering new ways of ....Engaging science students' hearts and minds: Researching science teachers' professional learning in the development of contemporary understandings of scientific literacy. This project will develop, support and value the work of science teachers in developing students' scientific literacy and share the subsequent knowledge gains in the educational community to positively advance quality teaching and learning in school science. Improving science teaching and learning hinges on offering new ways of responding to the problems inherent in teaching science in the 21st century. By supporting and encouraging the creative and innovative ideas, concepts and approaches to quality science teaching and learning embedded in teachers' professional learning the development of the critical knowledge for challenging the status-quo will be advanced.Read moreRead less
The role of subject-matter knowledge in teaching science and mathematics: Practices of teachers with advanced qualifications in the sciences. High quality science and mathematics education is central to economic prosperity. This study will achieve two outcomes. Firstly it explores the importance of subject matter knowledge in teaching. Much has been studied about the knowledge of teachers but limited research has been conducted with teachers who have substantial subject-matter knowledge. These f ....The role of subject-matter knowledge in teaching science and mathematics: Practices of teachers with advanced qualifications in the sciences. High quality science and mathematics education is central to economic prosperity. This study will achieve two outcomes. Firstly it explores the importance of subject matter knowledge in teaching. Much has been studied about the knowledge of teachers but limited research has been conducted with teachers who have substantial subject-matter knowledge. These findings will inform the current debate about the appropriate models of teacher education and the balance of emphasis on content knowledge and pedagogical knowledge. Secondly, given a number of attempts to attract mid career professionals with high qualifications to teaching, the study will provide evidence on how these people transition to their new careers and what support is needed.Read moreRead less
Comparative Analysis of Early Intervention Programs for Young Children with Autism. This project will contribute valuable information on how agencies and governments nationally and overseas can cater for a rapidly growing number of students identified with autism. Two early intervention programs - home-based and centre-based - for young children with autism and their families will be compared to each other and a control group. Through promoting strong family knowledge about autism, strategies fo ....Comparative Analysis of Early Intervention Programs for Young Children with Autism. This project will contribute valuable information on how agencies and governments nationally and overseas can cater for a rapidly growing number of students identified with autism. Two early intervention programs - home-based and centre-based - for young children with autism and their families will be compared to each other and a control group. Through promoting strong family knowledge about autism, strategies for managing a young child with autism (e.g., communication, social skills), plus fostering inter-family and community links, families will be empowered to promote healthy outcomes for their young child.Read moreRead less
Comparative effectiveness of three literacy teaching approaches for young children with reading difficulties. This project addresses concerns expressed by the Minister for Education, Science and Training, and the Australian Senate in regard to the relative poor performance of Australian children in national reading tests. Specifically, the project seeks to identify the most effective early literacy instructional method or methods to redress the growing concern that Australian children are droppi ....Comparative effectiveness of three literacy teaching approaches for young children with reading difficulties. This project addresses concerns expressed by the Minister for Education, Science and Training, and the Australian Senate in regard to the relative poor performance of Australian children in national reading tests. Specifically, the project seeks to identify the most effective early literacy instructional method or methods to redress the growing concern that Australian children are dropping behind in international competitiveness in reading and literacy achievement. The study concentrates on early reading development and to inform on teacher education and classroom teaching practices. Read moreRead less