Modelling The Impact Of Strategies To Control Gonorrhoea And Minimise The Threat Of Antimicrobial Resistance In Remote Indigenous And Other High Risk Populations
Funder
National Health and Medical Research Council
Funding Amount
$467,079.00
Summary
Gonorrhoea is a serious public health issue in Australia. Notification rates are disproportionately high among Aboriginal and Torres Strait Islander people and men who have sex with men, and there is evidence of an emerging epidemic in the general heterosexual population. Additionally, available treatments are under threat from resistant strains. We will use mathematical modelling to evaluate strategies for controlling gonorrhoea and for minimising the threat of antimicrobial resistance.
Neisseria Gonorrhoeae Antmicrobial Resistance: Detection And Propagation
Funder
National Health and Medical Research Council
Funding Amount
$435,129.00
Summary
Neisseria gonorrhoeae, the pathogen that causes gonorrhoea, has developed resistance to multiple classes of antibiotics. The last remaining class of antibiotics that can successfully be used for general treatment of gonorrhoea is extended spectrum cephalosporins (ESCs). However, we are now starting to see Neisseria gonorrhoeae isolates with early signs of ESC resistance. This research will use molecular technology and mathematical modelling to investigate Neisseria gonorrhoeae antimicrobial resi ....Neisseria gonorrhoeae, the pathogen that causes gonorrhoea, has developed resistance to multiple classes of antibiotics. The last remaining class of antibiotics that can successfully be used for general treatment of gonorrhoea is extended spectrum cephalosporins (ESCs). However, we are now starting to see Neisseria gonorrhoeae isolates with early signs of ESC resistance. This research will use molecular technology and mathematical modelling to investigate Neisseria gonorrhoeae antimicrobial resistance in Australia.Read moreRead less
Gonorrhoea: Detection, Antimicrobial Resistance And Treatment.
Funder
National Health and Medical Research Council
Funding Amount
$463,652.00
Summary
Rates of gonorrhoea are extremely high in Indigenous populations of Australia, and the gonorrhoea bug has now developed resistance to almost all antibiotics that have been used to treat it. In this study, we will investigate a new means of diagnosing the infection, as well as better ways to detect gonorrhoea drug resistance. By doing so, we will ensure that gonorrhoea infections are better managed, particularly in our Indigenous populations.
Use Of Molecular Resistance Assays To Provide Alterative Oral Treatment Strategies For Gonorrhoea In Indigenous And Other High-risk Populations; A Randomised Cluster Trial
Funder
National Health and Medical Research Council
Funding Amount
$828,671.00
Summary
Gonorrhoea has now developed resistance to almost all antibiotics that have been used to treat it. In this study, we will investigate a new treatment approach that selects antibiotics on a patient-by-patient basis. We will use new molecular assays to first test if a gonorrhoea strain infecting a patient is susceptible to an antibiotic, and will then treat on the basis of this result. By doing so, we will optimize our use of antibiotics and improve treatment strategies for gonorrhea.
Sexually Transmissible Infections: Outcomes And Interventions.
Funder
National Health and Medical Research Council
Funding Amount
$568,892.00
Summary
Professor Basil Donovan, Head of the Sexual Health Program at UNSW's Kirby Institute, works on a wide range of research endeavours that are aimed at (a) better characterising the causes of sexually transmissible infections (STIs) and their outcomes, (b) determining how they move through populations, and (c) trialing interventions to bring them under control. He has a particular interest in populations that are at increased risk of STIs such as Aboriginal and Torres Strait Islander people, gay me ....Professor Basil Donovan, Head of the Sexual Health Program at UNSW's Kirby Institute, works on a wide range of research endeavours that are aimed at (a) better characterising the causes of sexually transmissible infections (STIs) and their outcomes, (b) determining how they move through populations, and (c) trialing interventions to bring them under control. He has a particular interest in populations that are at increased risk of STIs such as Aboriginal and Torres Strait Islander people, gay men, sex workers, prisoners, and youth.Read moreRead less