Many heart diseases are associated with impairment of energetics of the heart. Improving the heart's energetics can lead to improved survival and long-term outcomes. Perhexiline is a heart medication that works by improving the way the heart uses energy. Although effective, it is associated with long-term toxicities. Better understanding of this medication may lead to less adverse effects and also provide a basis for further investigation of drug development in the future.
Closed-loop Insulin Delivery Compared With Islet Cell Transplantation For Adults With Type 1 Diabetes And Impaired Awareness Of Hypoglycaemia
Funder
National Health and Medical Research Council
Funding Amount
$92,745.00
Summary
Hypoglycaemia in adults with type 1 diabetes is common. Evaluation of therapies – the ‘artificial pancreas’ and islet cell transplantation - is warranted in a cohort with repeated episodes of hypoglycaemia. This proposal will assess whether the ‘artificial pancreas’ and islet cell transplantation, compared with usual insulin therapy, will reduce hypoglycaemia and improve other clinical outcomes over 6 months. This has potential to expand therapies used in current clinical practice.
Patient Safety And Therapeutic Implications Of A New Glucose Lowering Agent For Type 2 Diabetes And High Blood Glucose States In The Critically Ill
Funder
National Health and Medical Research Council
Funding Amount
$88,193.00
Summary
Dr Mark Plummer is a young intensive care trainee and scientist whose research activities are clinically based and relate primarily to the therapeutic implications of novel blood glucose lowering agents in diabetes and critical illness. He also has an interest into the effects of critical illness on upper gastrointestinal function. The results of these studies are expected to lead to safer drug regimens to control high blood sugar levels for diabetics in the community as well as in the intensive ....Dr Mark Plummer is a young intensive care trainee and scientist whose research activities are clinically based and relate primarily to the therapeutic implications of novel blood glucose lowering agents in diabetes and critical illness. He also has an interest into the effects of critical illness on upper gastrointestinal function. The results of these studies are expected to lead to safer drug regimens to control high blood sugar levels for diabetics in the community as well as in the intensive care unit.Read moreRead less
Understanding Changes In Retinal Ganglion Cells Using A Glaucoma Model
Funder
National Health and Medical Research Council
Funding Amount
$88,193.00
Summary
Glaucoma is a pressure related eye disease that is the second leading cause of blindness worldwide. The mechanisms by which glaucoma causes vision loss are poorly understood. At the Centre for Eye Research Australia, we aim to investigate changes within retinal ganglion cells – the neurons which carry light signal from the eye to the brain – using a glaucoma model. We hope to improve understanding of the disease process and highlight new therapeutic options for glaucoma.