Preventing Diabetes In Pregnancy From Progressing To Type 2 Diabetes: Macrolevel System Change In South Australia And Vic
Funder
National Health and Medical Research Council
Funding Amount
$1,338,281.00
Summary
The greatest predictor of the likelihood of developing diabetes is having diabetes during pregnancy. This project will invite women who have developed diabetes during pregnancy to be registered for recall every two years. They would go to their general practitioner to be tested for diabetes and to be advised on risk factors for diabetes. A lifestyle modification program will be developed for these women to reduce the risk of progressing to diabetes.
Gestational diabetes (GDM) is a common complication of pregnancy with significant consequences. Early identification and lifestyle intervention can prevent GDM, but the best early screening test is unknown. Our primary aim is to validate our first trimester screening test for GDM in a large multi-ethnic cohort to accurately predict high-risk women and intervene early, preventing GDM onset and improving pregnancy outcomes, including long-term risk of obesity in the offspring.
Analysis Of Effect Of Different Treatment Targets On Maternal And Child Health Outcomes In Gestational Diabetes Mellitus (GDM), Review Of Specific Treatments And Development Of Clinical And Biochemical Predictors.
Funder
National Health and Medical Research Council
Funding Amount
$122,686.00
Summary
This research aims to analyse newly proposed treatment targets for Gestational Diabetes Mellitus (GDM) and the effect this will have on maternal and child health outcomes, via comparison of data from two large Australian health services using the traditional and newly proposed critiera. The research will also investigate current effective interventions for GDM, including the impact of early antenatal lifestyle interventions, and formulation of a clinical and biochemical risk prediction model.
Assessing The Effect Of Carbohydrate Intake In Overweight And Obese Pregnant Women And In Women With Gestational Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$124,075.00
Summary
Women with Gestational Diabetes Mellitus (GDM) have more adverse pregnancy outcomes than the general population. These adverse outcomes are related to glucose levels. Given that carbohydrate is metabolised to glucose by the body, it is plausible that a lower carbohydrate diet will lead to improved glucose levels in these women. The aim of this research is to evaluate the relationship between carbohydrate intake, glucose levels and pregnancy outcomes in women with GDM.
Gestational diabetes is an important medical condition. We plan to investigate two subgroups of women with gestational diabetes. Firstly, women who have diabetes antibodies in pregnancy. Secondly, women who have a mild form of diabetes caused by a single gene mutation, who may be first identified during pregnancy. Correct identification of these subgroups of women is important for immediate and long-term management of both the mother and her fetus.
The Treatment Of BOoking Gestational Diabetes Mellitus Study: The TOBOGM Study
Funder
National Health and Medical Research Council
Funding Amount
$2,197,280.00
Summary
Gestational diabetes mellitus (GDM) related pregnancy complications are reduced with treatment from 24-28 weeks pregnant. Many women are diagnosed/treated earlier without evidence of benefit and possible risk of harm. In TOBOGM women under 20 weeks pregnant with mildly raised blood glucose will be allocated by chance to either immediate treatment, or awaiting a repeat diabetes test at 24-28 weeks pregnant to decide treatment. Harmful and beneficial effects on mother and baby will be compared.
Epigenetics Of Human Placental Development And Pregnancy-associated Disease.
Funder
National Health and Medical Research Council
Funding Amount
$85,526.00
Summary
Mounting evidence suggests that epigenetic changes such as DNA methylation during pregnancy may play an important role in adverse pregnancy outcomes and modulation of disease risk later in life. We have identified a range of distinct DNA methylation events in human placental cells that are likely to play a role in both normal human placentation and aspects of placental dysfunction. We believe that disruption of this epigenetic profile contributes to adverse pregnancy outcomes