Dnmt3L Haploinsufficent Retrotransposition Leads To Genetic Hypermutation
Funder
National Health and Medical Research Council
Funding Amount
$613,982.00
Summary
This project aims to demonstrate the critical importance of DNA methylation as a cause of mutation and thus genetic diseases, many instances of sterility and low fertility, and cancers. Because DNA methylation can be partially determined by substrate availability, a demonstration of the importance of DNA methylation vis a vis mutation rates will refine our understanding of the impact of metabolism and nutrition on mutation rate as a cause of human disease.
Epigenetic Regulation Of Monoallelic Gene Expression During Development.
Funder
National Health and Medical Research Council
Funding Amount
$655,035.00
Summary
Upon completion of the human genome sequence focus has shifted to understanding the epigenetic mechanisms that help interpret the encoded information to allow the cell growth and differentiation essential for an organism during development. These mechanisms are disrupted in diseases like cancer, where gene expression is disrupted to favour disease progression. This project will study the genes and epigenetic mechanisms that determine how gene expression patterns are established and maintained.