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Recovery and characterization of monooxygenases for biocatalysis and bioremediation through development of novel DNA- and protein-based technology. Australia contains hundreds of sites contaminated with toxic waste and judged to pose significant risk of harm to the public. This project will identify enzymes and organisms capable of remediating such contaminated sites by natural processes. It will also result in training of persons and development of techniques that will contribute to making bi ....Recovery and characterization of monooxygenases for biocatalysis and bioremediation through development of novel DNA- and protein-based technology. Australia contains hundreds of sites contaminated with toxic waste and judged to pose significant risk of harm to the public. This project will identify enzymes and organisms capable of remediating such contaminated sites by natural processes. It will also result in training of persons and development of techniques that will contribute to making bioremediation an environmentally sustainable and cost-effective technology. The environmental proteomics strategy is a frontier technology, expected to have broad applications in health, food science and the environment. Our development of this technology will create a wide range of opportunities for Australian scientists and companies.Read moreRead less
Enabling Technologies for Structural Genomics. New technologies will be developed to save time, money and effort in rapid preparation of protein samples for structural genomics. Systems will be devised for preparing sufficient isotope-labelled proteins for nuclear magnetic resonance spectroscopy without using living organisms, for efficiently identifying points at which proteins can be broken into smaller fragments with the right properties, and for joining the ends of proteins and peptides toge ....Enabling Technologies for Structural Genomics. New technologies will be developed to save time, money and effort in rapid preparation of protein samples for structural genomics. Systems will be devised for preparing sufficient isotope-labelled proteins for nuclear magnetic resonance spectroscopy without using living organisms, for efficiently identifying points at which proteins can be broken into smaller fragments with the right properties, and for joining the ends of proteins and peptides together to make them much more stable. This combination of technologies are widely applicable to current problems in protein chemistry, molecular biology, functional genomics and the medical sciences.Read moreRead less
Disulfide Bonds and Protein Folding. This work will advance our understanding of protein folding, which has important implications in biotechnology, impacting on commercial production of recombinant proteins (for pharmaceutical and biomedical applications) and on 1000s of research laboratories worldwide that use recombinant technologies. This research could also contribute to medicine (new treatments for diseases of protein misfolding like Alzheimer's), and to membrane protein structural biology ....Disulfide Bonds and Protein Folding. This work will advance our understanding of protein folding, which has important implications in biotechnology, impacting on commercial production of recombinant proteins (for pharmaceutical and biomedical applications) and on 1000s of research laboratories worldwide that use recombinant technologies. This research could also contribute to medicine (new treatments for diseases of protein misfolding like Alzheimer's), and to membrane protein structural biology. This work could yield economic benefits in the long-term through patentable outcomes and will benefit the community by producing high impact research papers, providing training to Australians and forging links with renowned international scientists.Read moreRead less
Uncertain Information Processing for Situation Awareness and Dynamic Decision-Making in Emergency Management. The Australian national counter-terrorism committee indicates that Australia should have a strong intelligence-led prevention and preparedness to support Australia on risk management, emergency services and maintaining capabilities to manage various types of terrorist attacks. The proposed situation awareness support technique can be used to develop situation analysis software systems or ....Uncertain Information Processing for Situation Awareness and Dynamic Decision-Making in Emergency Management. The Australian national counter-terrorism committee indicates that Australia should have a strong intelligence-led prevention and preparedness to support Australia on risk management, emergency services and maintaining capabilities to manage various types of terrorist attacks. The proposed situation awareness support technique can be used to develop situation analysis software systems or directly support Australia government agencies and industries to correctly assess a situation, increase awareness for crisis problems, and therefore improve emergency management and decision-making effectiveness, in particular, for avoiding disaster problems in the first place and preparing plans for those that undoubtedly will occur. Read moreRead less
Teaching Software Agents to Play. This project is fundamental to computational intelligence and human brain science. Both strongly impact on the community and the nation. They form the backbone of contemporary information science and are key to our National Research Priorities. This research is of great community benefit. Our results will enable everyone to rapidly search, analyse and interpret vast amounts of information that is irretrievable by current methods. They will also enliven interacti ....Teaching Software Agents to Play. This project is fundamental to computational intelligence and human brain science. Both strongly impact on the community and the nation. They form the backbone of contemporary information science and are key to our National Research Priorities. This research is of great community benefit. Our results will enable everyone to rapidly search, analyse and interpret vast amounts of information that is irretrievable by current methods. They will also enliven interactive entertainment by spontaneously creating unique, tailor-made music. In sum, we are making a leap forward in the crucial area of collaborative intelligence.Read moreRead less
The Physics of Network Computation. This project combines expertise in nonlinear soliton physics and computational sciences in order to provide new insights into the physics of network computation. Our proposal addresses the mathematics and computer modelling underlying nonconscious problem solving. We develop a new template concept, the meta-mode, which embodies the network structure of knowledge and the linking mechanisms, which underpin human creativity. We establish the optimal connectiv ....The Physics of Network Computation. This project combines expertise in nonlinear soliton physics and computational sciences in order to provide new insights into the physics of network computation. Our proposal addresses the mathematics and computer modelling underlying nonconscious problem solving. We develop a new template concept, the meta-mode, which embodies the network structure of knowledge and the linking mechanisms, which underpin human creativity. We establish the optimal connectivity distributions to preserve distinct pattern classes yet allow model radical shifts in paradigms, and develop algorithms for autonomous connectivity optimisation. We investigate nonlinear process such as solitons and random Boolean networks as realisations of these principles.Read moreRead less