A Longitudinal Study Of Psychopathology In People With Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$999,803.00
Summary
This project will further develop the research opportunities of an internationally unique 15 year follow up study of the mental health of young Australians with ID. We have shown that this group has 2-3 times the risk of suffering serious emotional and behavioural problems that are an added heavy burden on the individual, their family and carers and the community. These problems often are not recognised but are as common as schizophrenia in the community. The study will continue to use a combina ....This project will further develop the research opportunities of an internationally unique 15 year follow up study of the mental health of young Australians with ID. We have shown that this group has 2-3 times the risk of suffering serious emotional and behavioural problems that are an added heavy burden on the individual, their family and carers and the community. These problems often are not recognised but are as common as schizophrenia in the community. The study will continue to use a combination of questionnaire survey and in depth interviews of the young adults and their families or carers to track the course of their mental health. The study commenced in 1990 with nearly 1000 young people with ID aged 4-18 years and their progress has been reviewed every 2-3 years in over 75% of the original group. During the next 5 years we plan to follow their mental health during the critical stage of young adult life. During this time there is the greatest risk of mental illnesses such as depression and schizophrenia and the stresses of adjusting to new daily occupations, independent living or residential care and social contact away from the family. We will be able to study the specific emotional and behavioural problems faced by young adults with the main known causes of ID such as Down, Fragile X, Prader Willi and William Syndromes, as well as those who have autism. The great benefit of a long term follow up study is that it allows us to study the links between earlier family environmental, psychological and biological factors and subsequent mental health problems. We can also demonstrate the impact that mental illness in a young person with ID has on the family and parental mental health. The findings have implications for better diagnosis, improved care and management, early intervention and prevention of these common severe and under recognized mental health problems in this disadvantaged group of young Australians and their families and carers.Read moreRead less
Risk Factors For The Development Of Eating Disorder Phenotypes And Endophenotypes In Adolescent Twins
Funder
National Health and Medical Research Council
Funding Amount
$266,500.00
Summary
The overall aim of the project is to develop a better understanding of how environment, temperament and genes work together to cause disordered eating and eating disorders. Eating disorders, including anorexia nervosa and bulimia nervosa, are an extremely difficult and costly condition to treat, and are associated with high mortality. Eating disorders in adolescence lead to increased risk for anxiety disorders, chronic fatigue, chronic pain, depressive disorders, infectious diseases, suicide att ....The overall aim of the project is to develop a better understanding of how environment, temperament and genes work together to cause disordered eating and eating disorders. Eating disorders, including anorexia nervosa and bulimia nervosa, are an extremely difficult and costly condition to treat, and are associated with high mortality. Eating disorders in adolescence lead to increased risk for anxiety disorders, chronic fatigue, chronic pain, depressive disorders, infectious diseases, suicide attempts, and limitation in activities due to poor health in adulthood. Full- and partial-syndrome eating disorders affect around 10% of adolescent girls. Given the seriousness of the consequences of eating disorders, and the large number of Australians affected, a better understanding of what causes the development of eating disorders is required. The current research investigates identical and non-identical adolescent female twins aged 13-15 years. As well as examining their eating, this study will look at the sort of environments and temperaments that may increase genetic susceptibility to develop eating problems. The types of environment to be examined include media influence, weight related peer teasing, parental dieting, and pre- and pernatal complications. Twin temperament will also be examined, including perfectionism, sense of ineffectiveness, body dissatisfaction and depression. Parental anxiety and novelty seeking will also be examined for impact on the development of disordered eating in their children. The twins will be followed up over a 2-year period, the peak risk age for onset of eating problems. By comparing the identical and non-identical twins, we can define the characteristics of those most at risk of developing eating problems. The results of this project can be used to formulate specific prevention strategies.Read moreRead less
Genetic And Environmental Contributions To The Life Course Of The Common Mental Disorders
Funder
National Health and Medical Research Council
Funding Amount
$1,529,567.00
Summary
The common mental disorders (anxiety, depression, substance use) constitute a major disease burden and cost on the health system. Little is known about their causes and patterns of occurrence over the life span. This study follows a sample of 4000 persons from birth to 30 years of age to determine the environmental and genetic factors that lead to the onset and recurrence of the common mental disorders. It will provide important information to influence the treatment and prevention of these diso ....The common mental disorders (anxiety, depression, substance use) constitute a major disease burden and cost on the health system. Little is known about their causes and patterns of occurrence over the life span. This study follows a sample of 4000 persons from birth to 30 years of age to determine the environmental and genetic factors that lead to the onset and recurrence of the common mental disorders. It will provide important information to influence the treatment and prevention of these disorders.Read moreRead less
A Longitudinal Study Of Depression, Anxiety, Substance Use And Cognitive Change: PATH Through Life Wave 3
Funder
National Health and Medical Research Council
Funding Amount
$2,068,954.00
Summary
The PATH Through Life study is a longitudinal study of depression, anxiety, alcohol and drug use. It is also a study of normal cognitive development, mild cognitive impairment and dementia. PATH involves three cohorts of adults who were aged 20-24, 40-44 and 60-64 at baseline. They are followed up at four yearly intervals. This application seeks funding for Wave 3 of the study, which will allow for 8 years of follow-up of the baseline sample to be conducted. The key aims are to discover the rela ....The PATH Through Life study is a longitudinal study of depression, anxiety, alcohol and drug use. It is also a study of normal cognitive development, mild cognitive impairment and dementia. PATH involves three cohorts of adults who were aged 20-24, 40-44 and 60-64 at baseline. They are followed up at four yearly intervals. This application seeks funding for Wave 3 of the study, which will allow for 8 years of follow-up of the baseline sample to be conducted. The key aims are to discover the relationships between biological and psychological processes in depression, anxiety, substance abuse and cognitive ageing; to identify the socio-demographic factors contributing to these disorders, and to quantify more fully the range of social and economic consequences of mental illness and cognitive decline. Such consequences include reduced workforce participation, relationship breakdown, family and carer burden, suicide attempts, use of health services and need for social welfare. Wave 3 will also focus on transitions into parenthood, fertility and mental health, menopause, and retirement. Factors in early and mid-adulthood that influence healthy ageing and cognitive decline in late life will be identified. Information is obtained on physical health, health habits , social networks, employment and work stress, lifestyle activities, personality, family structure, physical function and cognitive performance. DNA has also been obtained and a sub-sample of the oldest cohort also participate in a study of brain MRIs. Longitudinal analysis is the only means of distinguishing the causes of disorders and tracking their development within individuals. PATH is unique in its narrow age-group design and breadth of measures, allowing for detailed understanding of the pathways to mental health and illness, and for identification of how to prevent mental illness and dementia.Read moreRead less
Anxiety and depression are common during early- to mid-adulthood and a major cause of disability. Few studies track individuals over this age range or assess how their experience of anxiety/depression affects them at midlife when many of life’s work, family and personal achievements coalesce. The PATH to Midlife project extends an existing community survey to understand the patterns of anxiety and depression from early to mid-adulthood and identify the personal, social and economic consequences.
An Investigation Of The Effects Of Higher Plasma Glucose In The Normal Range On Cerebral Health.
Funder
National Health and Medical Research Council
Funding Amount
$727,524.00
Summary
Until recently it has been assumed that variation in blood sugar levels within the normal range in non-diabetics is innocuous. Recent findings from our team suggest that high normal sugar levels present risks to brain and cognitive health. This project will investigate in detail the extent to which higher sugar levels in healthy individuals living in the community are associated with brain changes over time, and whether these changes are associated with cognitive decline in middle- and old-age.
Lifecourse And Global Epidemiology Of Adolescent Health And Wellbeing
Funder
National Health and Medical Research Council
Funding Amount
$863,910.00
Summary
In the past 20 years, my group has become the world-leader in adolescent health research. We have published papers that have transformed thinking on adolescent health. In the next five years, we will undertake research into the effects of puberty on mental health, explore the effects of health prior to pregnancy on a healthy start to life for the next generation and undertake global research that will enable the roll-out of new multi-billion dollar investments in adolescent health.
Preventing Suicide In India By Improving Media Reporting Of Suicides
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Suicide rates in India are among the highest in the world, resulting in over 258,000 suicide deaths annually with far-reaching socio-economic effects. One of the few successful suicide prevention strategies at the population level is responsible media reporting of suicides. This fellowship will support the applicant to undertake pioneering research on media reporting of suicides in India, with potential for a profound impact on media practices, suicide rates and suicide prevention awareness.