Dissecting Genetic Variation For Human Complex Diseases And Traits
Funder
National Health and Medical Research Council
Funding Amount
$135,821.00
Summary
Understanding the pattern of inheritance for human common diseases such as cancers, obesity, diabetes and mental illness, is of key importance for disease diagnosis, treatment and prevention. In this project, we will develop statistical methods and software tools to analyse DNA and clinical data to better understand the genetic basis of human common diseases and to predict a person�s risk of developing disease.
Validation And Replication Of Genes Associated With Common Human Disease Using Australian Twin Families
Funder
National Health and Medical Research Council
Funding Amount
$921,224.00
Summary
The European Network for Genetic and Genomic Epidemiology (ENGAGE) aims to translate the wealth of data emerging from large-scale research efforts in molecular epidemiology into information of direct relevance to future advances in clinical medicine. ENGAGE will do this through the integration of very large datasets already available from a substantial number of large and well-characterised samples. The resulting ENGAGE resource will represent a research investment >€100M (>AU$160M) and pr ....The European Network for Genetic and Genomic Epidemiology (ENGAGE) aims to translate the wealth of data emerging from large-scale research efforts in molecular epidemiology into information of direct relevance to future advances in clinical medicine. ENGAGE will do this through the integration of very large datasets already available from a substantial number of large and well-characterised samples. The resulting ENGAGE resource will represent a research investment >€100M (>AU$160M) and provide unprecedented power to discover disease and trait susceptibility genes. QIMR will contribute 12,000 twins for ENGAGE joint analyses and provide analytical expertise in the analysis of disease and genetic data related to lifestyle and metabolic traits, with particular emphasis on cardiovascular disease, type 2 diabetes and migraine risk factors. Our laboratory will also perform vital further genetic studies to establish the causal relationship between the genetic variants concerned and the traits of interest. Most importantly, our direct participation will allow the translation of these findings into the Australian population and clinical arena.Read moreRead less
Defining The Role Of Genomic Structural Variations In Hypertension And Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$379,597.00
Summary
High blood pressure is caused by a variety of inherited alterations (mutations) in the letters our DNA and lifestyle. The aim of this project is to investigate gains and losses of large portions of DNA sequences consisting of between ten thousand and over a million letters (known as Copy Number Variation). We will compare the DNA of subjects who have high blood pressure with subjects who are normal. This discovery of changes may help diagnosis, prevention and treatment.
New Computational Methods For The Analysis Of Whole-genome Data
Funder
National Health and Medical Research Council
Funding Amount
$151,516.00
Summary
A complete understanding of the mechanisms underlying common diseases can only be achieved if all pathways at which genetic variation contributes to disease risk are identified. Most available methods to identify such predisposing genetic variation are adequately powered only when analysing data for many thousands of samples. We will develop more powerful statistical methods that can increase our ability to identify disease genes from large-scale association studies.
I am a human geneticist studying the genetics (molecular genetics and heredity) and variation of common complex human traits and disease, in particular, migraine and endometriosis.
Finding The Genetic Causes Of Asthma: The Australian Asthma Genetics Consortium (AAGC)
Funder
National Health and Medical Research Council
Funding Amount
$1,697,639.00
Summary
Asthma is a major burden on individuals and health systems. Despite many decades of research, no major effective new treatments for asthma have emerged recently. We will establish a large international consortium to systematically test nearly all known human genes to identify those that influence asthma susceptibility. We expect to identify pathways not previously implicated in asthma and so lead to a potential breakthrough in the development of more effective treatments.
Accurate Prediction Of Individual Risk To Disease From Genome-wide Association Studies
Funder
National Health and Medical Research Council
Funding Amount
$269,371.00
Summary
Risk for many complex diseases (such as psychiatric disorders or heart disease) has a substantial genetic component, however few specific high risk variants have been identified. Evidence is mounting that there are likely to be hundreds of risk loci each individually conferring a very low increase in relative risk for disease. We aim to develop methods that utilise information from multiple genetic risk variants simultaneously to create a 'genomic profile' of risk.
Translation Of Genetic Findings Into Improved Health Outcomes For Common Eye Diseases In Our Society
Funder
National Health and Medical Research Council
Funding Amount
$675,736.00
Summary
Associate Professor Paul Baird of the Centre for Eye Research Australia, University of Melbourne specialises in identifying and understanding how genetic changes are involved in causing the commonest causes of vision loss and blindness in our society including age related macular degeneration, short-sightedness and glaucoma. His Fellowship will be used to better understand how genes and environment cause these diseases, allowing translation of findings intto new and improved treatments for patie ....Associate Professor Paul Baird of the Centre for Eye Research Australia, University of Melbourne specialises in identifying and understanding how genetic changes are involved in causing the commonest causes of vision loss and blindness in our society including age related macular degeneration, short-sightedness and glaucoma. His Fellowship will be used to better understand how genes and environment cause these diseases, allowing translation of findings intto new and improved treatments for patients.Read moreRead less
Genome-wide Association Study Of Migraine In Women With Endometriosis
Funder
National Health and Medical Research Council
Funding Amount
$320,036.00
Summary
Typical migraine, is a frequent, debilitating and painful disorder that affects people during their most productive years (25% of females and 7.5% of males). Women suffering endometriosis (a painful gynecologic disorder affecting up to 10% of women) are at an increased risk of suffering migraine headaches. Our proposed collection of migraine phenotype data on our endometriosis cohort will facilitate identification of genes underlying both disorders.
CAGE: Consortium For The Architecture Of Gene Expression
Funder
National Health and Medical Research Council
Funding Amount
$501,080.00
Summary
This research project is about understanding why some people are most susceptible to disease than others, by identifying genetic factors that influence the expression of genes that are important in disease. We will work with leaders in the field in Europe and the USA in an international research consortium to find genetic variants with an effect on gene expression and to link those genetic factors to disease. The project will provide new understanding about the biological basis of common disease ....This research project is about understanding why some people are most susceptible to disease than others, by identifying genetic factors that influence the expression of genes that are important in disease. We will work with leaders in the field in Europe and the USA in an international research consortium to find genetic variants with an effect on gene expression and to link those genetic factors to disease. The project will provide new understanding about the biological basis of common diseases.Read moreRead less