Evaluating The Genetic Contribution To Rheumatic Heart Disease Pathogenesis In Australian Aboriginal And Torres Strait Islander Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,782,074.00
Summary
Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.
Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We ....Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We will generate antibody fragments that bind these MP and express them in tomato. We will analyse antibody expression in tomato and study their association with the phytoplasma membrane. Transgenic plants will be inoculated with phytoplasma and monitored for resistance. This work represents a major step towards engineering resistance to phytoplasmas.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989147
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to bi ....Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to biomolecular research in medicine, agriculture and environmental biology, thereby providing major benefits to the wider community. The application will enhance existing genomic technologies by substantially increasing the scope of experiments that can be performed leading to important advances in gene discovery.Read moreRead less
Bringing back Australia's lost woodland biodiversity: towards strategic multi-species reintroductions. Australia has the highest rate of mammal extinction of any continent on the planet. This has reduced biodiversity and compromised many important ecological processes. What is the best way to re-build depauperate mammal communities with multi-species reintroductions? What effects do multi-species reintroductions have on recipient ecosystems? This project aims to explore these questions by reintr ....Bringing back Australia's lost woodland biodiversity: towards strategic multi-species reintroductions. Australia has the highest rate of mammal extinction of any continent on the planet. This has reduced biodiversity and compromised many important ecological processes. What is the best way to re-build depauperate mammal communities with multi-species reintroductions? What effects do multi-species reintroductions have on recipient ecosystems? This project aims to explore these questions by reintroducing three mammal species to a critically endangered temperate woodland: a carnivore (the eastern quoll), an insectivore (yellow-footed antechinus), and a herbivore (the eastern chestnut mouse). Results from this sequenced multi-species reintroduction experiment will have broad applicability to ecosystem restoration in Australia and overseas.Read moreRead less
A landscape-scale experimental test of factors driving mammal declines in northern Australia. Australia has suffered the highest rate of modern mammal extinctions in the world. Foxes have been largely responsible for this extinction in southern Australia and probably also Central Australia. However the decline in mammals in northern Australia has occurred later than that in the south, and in the absence of foxes. We will adopt an experimental approach to determine the mechanisms driving mammal d ....A landscape-scale experimental test of factors driving mammal declines in northern Australia. Australia has suffered the highest rate of modern mammal extinctions in the world. Foxes have been largely responsible for this extinction in southern Australia and probably also Central Australia. However the decline in mammals in northern Australia has occurred later than that in the south, and in the absence of foxes. We will adopt an experimental approach to determine the mechanisms driving mammal declines and extinctions in northern Australia. Populations of brush-tail tree rats (Conilurus penicillatus) will be translocated to suitable habitat on mainland sites that experience different fire regimes and predation pressures.Read moreRead less
Arresting declines of arboreal mammals in the tropical savannas. This project aims to evaluate the hypothesis that arboreal species are limited by the abundance of tree hollows, and that historical increases in the frequency of intense fires may be reducing hollow abundance. Northern Australia’s mammals are in severe decline, and arboreal species are among those that have fared worst. There is abundant anecdotal evidence that a decline in hollow abundance is the cause. Working with the Western A ....Arresting declines of arboreal mammals in the tropical savannas. This project aims to evaluate the hypothesis that arboreal species are limited by the abundance of tree hollows, and that historical increases in the frequency of intense fires may be reducing hollow abundance. Northern Australia’s mammals are in severe decline, and arboreal species are among those that have fared worst. There is abundant anecdotal evidence that a decline in hollow abundance is the cause. Working with the Western Australian Department of Parks and Wildlife in the Kimberley, the last region on the Australian mainland with an intact mammal fauna, the project aims to explore management options for increasing the availability of hollow denning sites for arboreal mammals (e.g. fire management, artificial nest boxes), and evaluate the likely impact of such actions on mammal populations across northern Australia.Read moreRead less
Conservation management of seed-eating birds in the tropical savannas. Biodiversity loss in the savannas indicates unsustainable management. This research will enhance our abilities to effectively manage Australia's tropical savannas, as well as contributing to several State and Territory, Commonwealth and international obligations to maintain biodiversity. Understanding the processes underlying current declines will also make the effects of future management or environment changes easier to pre ....Conservation management of seed-eating birds in the tropical savannas. Biodiversity loss in the savannas indicates unsustainable management. This research will enhance our abilities to effectively manage Australia's tropical savannas, as well as contributing to several State and Territory, Commonwealth and international obligations to maintain biodiversity. Understanding the processes underlying current declines will also make the effects of future management or environment changes easier to predict. Retaining threatened species can benefit remote and regional communities through tourism, and also through the extra employment required to implement the management prescriptions that will be developed from this research.Read moreRead less
Timber harvest management for the Aboriginal arts industry: socio-economic, cultural and ecological determinants of sustainability in a remote community context. The Aboriginal arts industry is one of few development opportunities for Indigenous people in remote communities: in some regions a vibrant industry has been established for three decades. Yet there has been limited research that has combined assessment of the social, ecological and economic determinants of arts production sustainabilit ....Timber harvest management for the Aboriginal arts industry: socio-economic, cultural and ecological determinants of sustainability in a remote community context. The Aboriginal arts industry is one of few development opportunities for Indigenous people in remote communities: in some regions a vibrant industry has been established for three decades. Yet there has been limited research that has combined assessment of the social, ecological and economic determinants of arts production sustainability. This project addresses this issue with reference to the rapidly expanding manufacture of sculptures marketed by Maningrida Arts and Culture in central Arnhem Land. The project will survey resource use and availability, examine the ecological and economic viability of this emerging artistic tradition and make practical recommendations to enhance sustainability.Read moreRead less
Mammal declines in northern Australia: science for conservation and recovery. Australia’s unique mammal fauna is a rich biological heritage for the nation. It provides a wealth of ecosystem services, and many mammal species have special cultural or aesthetic value. However, our mammals are sadly depleted, and we already have the worst record of recent mammal extinction of any nation. Preventing further mammal extinctions, and managing environments to allow declined mammals to recover, will be of ....Mammal declines in northern Australia: science for conservation and recovery. Australia’s unique mammal fauna is a rich biological heritage for the nation. It provides a wealth of ecosystem services, and many mammal species have special cultural or aesthetic value. However, our mammals are sadly depleted, and we already have the worst record of recent mammal extinction of any nation. Preventing further mammal extinctions, and managing environments to allow declined mammals to recover, will be of great benefit to Australian biodiversity and to the ecosystem processes and human values that depend on it.Read moreRead less
Creating fauna-friendly cities and towns - The ecology and conservation of insectivorous bats in Melbourne. Urbanisation is a principal threat to the conservation of biodiversity worldwide. Information on the response of plants and animals to an increasingly urbanized world is essential to prevent the loss of natural assets, ensure environmental sustainability and promote human health and well-being. This research will combine extensive field surveys with state-of-the art modeling to identify th ....Creating fauna-friendly cities and towns - The ecology and conservation of insectivorous bats in Melbourne. Urbanisation is a principal threat to the conservation of biodiversity worldwide. Information on the response of plants and animals to an increasingly urbanized world is essential to prevent the loss of natural assets, ensure environmental sustainability and promote human health and well-being. This research will combine extensive field surveys with state-of-the art modeling to identify their ecological requirements. Importantly, the research will engage with local councils, park managers and community organizations to educate the wider community and ensure research outcomes are adopted. The study design will ensure that the findings are applicable to other urban areas across Australia and around the world. Read moreRead less