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Discovery Early Career Researcher Award - Grant ID: DE190100609
Funder
Australian Research Council
Funding Amount
$368,000.00
Summary
Mechanobiology: a new model of integrin activation by membrane tension. This project aims to address a fundamental question in mechanobiology on how integrin receptor coordinates with force to mediate cell spreading, migration, growth and survival. With an observation that membrane deformation enhances integrin binding, the project expects to establish a new model of integrin activation by membrane tension. It will develop an integrated approach combining single-molecule force probes, super reso ....Mechanobiology: a new model of integrin activation by membrane tension. This project aims to address a fundamental question in mechanobiology on how integrin receptor coordinates with force to mediate cell spreading, migration, growth and survival. With an observation that membrane deformation enhances integrin binding, the project expects to establish a new model of integrin activation by membrane tension. It will develop an integrated approach combining single-molecule force probes, super resolution microscopy, microfluidics and molecular dynamics simulations. It is expected that the role of membrane tension in promoting cell adhesion will be defined at molecular scale, and the link between integrin activation and Piezo calcium channel mediated membrane tension sensing will be delineated.Read moreRead less
Tuning Molecular Translocaton by Close-Field Electroporation. This project aims to determine the underlying mechanisms by which DNA and other molecules are able to migrate across the cell membrane in response to highly localised electric fields. It has recently been shown that focusing of electric fields at the cellular level, using an array of small electrodes, results in unexpectedly high cell transfection efficiencies. It has been termed 'close-field electroporation'. Here it is proposed t ....Tuning Molecular Translocaton by Close-Field Electroporation. This project aims to determine the underlying mechanisms by which DNA and other molecules are able to migrate across the cell membrane in response to highly localised electric fields. It has recently been shown that focusing of electric fields at the cellular level, using an array of small electrodes, results in unexpectedly high cell transfection efficiencies. It has been termed 'close-field electroporation'. Here it is proposed to establish the properties of the electric fields around cells and cell membrane interactions with these fields that enable molecular translocation. This fundamental science could have broad implications in the domains of drug delivery, gene therapy and neural stimulation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100003
Funder
Australian Research Council
Funding Amount
$318,900.00
Summary
Vector network analyser suite for advanced terahertz materials and devices. This project aims to establish terahertz measurement capabilities to further Australia's strength and momentum in terahertz research. This will comprise of two terahertz extension modules, working with a dedicated vector-network analyser, and high-precision probes and probe station. The project will enable point-feeding, monochromatic, coherent, and fine spectral-resolution measurement at an atmospheric window of 220-330 ....Vector network analyser suite for advanced terahertz materials and devices. This project aims to establish terahertz measurement capabilities to further Australia's strength and momentum in terahertz research. This will comprise of two terahertz extension modules, working with a dedicated vector-network analyser, and high-precision probes and probe station. The project will enable point-feeding, monochromatic, coherent, and fine spectral-resolution measurement at an atmospheric window of 220-330 GHz. The capabilities are essential for development of two-dimensional materials, active components, waveguides, and antennas towards a common goal of efficient integrated terahertz devices and systems. The project will serve emerging terahertz applications including standoff imaging and short-range high-speed data transmission. This will have broad impact in the areas of surveillance, biomedicine, security, and public safety and well-being.Read moreRead less
Engineering high-efficiency all-dielectric antennas for terahertz channels. This project aims to create unconventional antenna platforms to support terahertz links. The project expects to deliver high-efficiency, high-gain dielectric resonator antennas and dielectric rod antenna arrays fed by dielectric wave-guides. The expected outcomes of this project will build critical components for future terahertz communication infrastructure. These antennas will support demands in point-to-point wireless ....Engineering high-efficiency all-dielectric antennas for terahertz channels. This project aims to create unconventional antenna platforms to support terahertz links. The project expects to deliver high-efficiency, high-gain dielectric resonator antennas and dielectric rod antenna arrays fed by dielectric wave-guides. The expected outcomes of this project will build critical components for future terahertz communication infrastructure. These antennas will support demands in point-to-point wireless transmission between mobile base stations, within data centres, and at information kiosks.Read moreRead less
Wideband Strongly-Truncated Composite Cavity-Resonator Antennas. A rapidly growing demand for fast wireless services calls for wideband communication systems with wideband antennas, which are compact, aesthetically appealing and inexpensive, yet have good performance. With novel concepts, this project aims to produce a new class of antennas that deliver impressive performance (bandwidth and gain) while taking up a dramatically reduced area in a way that was impossible before, increasing a figure ....Wideband Strongly-Truncated Composite Cavity-Resonator Antennas. A rapidly growing demand for fast wireless services calls for wideband communication systems with wideband antennas, which are compact, aesthetically appealing and inexpensive, yet have good performance. With novel concepts, this project aims to produce a new class of antennas that deliver impressive performance (bandwidth and gain) while taking up a dramatically reduced area in a way that was impossible before, increasing a figure-of-merit to up to seven times the state-of-the-art. Their planar geometry and simplicity lead to low cost. This is expected to create new knowledge, design methods and examples, prototypes, test results and guidelines required to design, optimise and make these versatile antennas for emerging robust broadband wireless systems.Read moreRead less
Silicon-Carbide Switches for Post-Silicon Efficiency of Power Electronics. The aim of this project is to create a prototype of a silicon carbide (SiC)-based power-electronic switch for improved energy efficiency and reduced size of power-electronic circuits, well beyond the theoretical limits of silicon technology. Until very recently, the dominant controlled switch in electronics could only be implemented as a silicon transistor. A new method of electronic passivation of SiC surfaces has enable ....Silicon-Carbide Switches for Post-Silicon Efficiency of Power Electronics. The aim of this project is to create a prototype of a silicon carbide (SiC)-based power-electronic switch for improved energy efficiency and reduced size of power-electronic circuits, well beyond the theoretical limits of silicon technology. Until very recently, the dominant controlled switch in electronics could only be implemented as a silicon transistor. A new method of electronic passivation of SiC surfaces has enabled the recent commercialisation of SiC transistors. It is expected that the material advantages of SiC can be fully exploited by a new device structure and a new fabrication process.Read moreRead less
Multiscale modelling of multiphase interactions in shale gas reservoirs. As conventional oil and gas become depleted in most of the producing basins, extraction of unconventional gas trapped in shale formations needs to become more viable. Since Australian shales have different characteristics from North American ones, the existing knowledge cannot be directly applied. We aim to develop a novel multiscale framework for deep understanding of the complex multiphase interactions in shale gas reserv ....Multiscale modelling of multiphase interactions in shale gas reservoirs. As conventional oil and gas become depleted in most of the producing basins, extraction of unconventional gas trapped in shale formations needs to become more viable. Since Australian shales have different characteristics from North American ones, the existing knowledge cannot be directly applied. We aim to develop a novel multiscale framework for deep understanding of the complex multiphase interactions in shale gas reservoirs. The outcomes will not only enable us to effectively assess the viability of gas extraction from Australian shale reservoirs with accurate long-term production forecasting, but help to develop strategies to effectively extract this relatively low carbon-emitting fossil fuel in the transition to a renewable economy.Read moreRead less
Multiscale physics theory to understand secondary migration of hydrocarbons. This project aims to derive mathematical models to reveal the geological history of how petroleum accumulates at laboratory, reservoir, and basin scales. The project will identify secondary migration trajectories of hydrocarbons from source rocks to stratigraphic traps, to optimise exploration for energy resources. By enabling multiscale analytical modelling, the new model will improve the reliability of reservoir chara ....Multiscale physics theory to understand secondary migration of hydrocarbons. This project aims to derive mathematical models to reveal the geological history of how petroleum accumulates at laboratory, reservoir, and basin scales. The project will identify secondary migration trajectories of hydrocarbons from source rocks to stratigraphic traps, to optimise exploration for energy resources. By enabling multiscale analytical modelling, the new model will improve the reliability of reservoir characterisation at the crucial initial exploitation stage, and prediction of oil-gas distribution in petroleum basin. The novel multiscale approach is expected to significantly improve exploration and exploitation and create highly skilled jobs to incorporate such modelling into the energy sector.Read moreRead less
Auditory perception in neural electronics. This project aims to develop a practical alternative to conventional electronic design. Faster and more powerful devices have resulted from placing ever more transistors on a computer chip, but this is reaching its physical limits. This project will develop a new way of designing smart electronic devices by taking inspiration from signal processing in biological brains, and applying it to the processing of audio signals. Expected outcomes are a device t ....Auditory perception in neural electronics. This project aims to develop a practical alternative to conventional electronic design. Faster and more powerful devices have resulted from placing ever more transistors on a computer chip, but this is reaching its physical limits. This project will develop a new way of designing smart electronic devices by taking inspiration from signal processing in biological brains, and applying it to the processing of audio signals. Expected outcomes are a device that recognises sounds, without needing remote computers to do the processing. These techniques can be applied to other senses, such as vision, advancing machine perception and enabling smarter devices.Read moreRead less
Multiscale physics for enhanced oil recovery. The project aims to develop a multiscale mathematical and laboratory modelling methodology for combined enhanced oil recovery (EOR) and CO2 storage, and synthesise the technology for Santos’s Mulberry oilfield as a test case. The multidisciplinary team will develop advanced reservoir- and laboratory-scale mathematical models and novel laboratory methods to enhance the reliability of modern EOR and CO2 storage and increase its uptake by companies in A ....Multiscale physics for enhanced oil recovery. The project aims to develop a multiscale mathematical and laboratory modelling methodology for combined enhanced oil recovery (EOR) and CO2 storage, and synthesise the technology for Santos’s Mulberry oilfield as a test case. The multidisciplinary team will develop advanced reservoir- and laboratory-scale mathematical models and novel laboratory methods to enhance the reliability of modern EOR and CO2 storage and increase its uptake by companies in Australia and globally. The expected outcomes are a pioneering methodology with environmental benefits without additional drilling and reduction of greenhouse effect, and economic benefit to the Australian oil industry through increases in productivity.Read moreRead less