Deciphering The Role Of Atypical DNA Methylation In Neuronal Genome Regulation And Neurological Disorders
Funder
National Health and Medical Research Council
Funding Amount
$773,484.00
Summary
This research will use a combination of genomic, biochemical and functional genomics approaches to investigate the role of the atypical mCH form of DNA methylation in neuronal genome regulation and function, and provide new insights into the role of the epigenome in healthy brain function and neural pathologies.
EPIGENETIC REPROGRAMMING OF MALIGNANT BREAST CANCER
Funder
National Health and Medical Research Council
Funding Amount
$863,268.00
Summary
Poorly differentiated breast cancers are aggressive tumors, frequently resistant to chemotherapy and associated with high morbidity. Herein we propose the engineering of more selective therapeutic agents able to target the genes involved in cancer initiation and resistance to treatment. We aim to correct and reprogram the cancer cell genome in state that is similar to normal, not tumorigenic cells. This work will generate novel forms of treatment for cancers that are presently not curable.
Telerehabilitation: Assessing Acquired Neurogenic Communication Disorders Online.
Funder
National Health and Medical Research Council
Funding Amount
$172,446.00
Summary
People who suffer brain damage as a result of a stroke, head injury, or a disorder such as Parkinson's disease frequently develop difficulty in either speaking, writing, reading, or understanding the spoken language. As a result, the person's ability to communicate with his or her family and friends, and the community in general is seriously affected. Individuals who experience these speech and language disorders are treated by a speech pathologist who focuses on improving the person's ability t ....People who suffer brain damage as a result of a stroke, head injury, or a disorder such as Parkinson's disease frequently develop difficulty in either speaking, writing, reading, or understanding the spoken language. As a result, the person's ability to communicate with his or her family and friends, and the community in general is seriously affected. Individuals who experience these speech and language disorders are treated by a speech pathologist who focuses on improving the person's ability to communicate. The treatment of these disorders is frequently long-term requiring speech pathology management beyond existing hospital care. For many people with these communication disorders, accessing speech pathology services after their discharge from hospital may be very difficult due to their physical difficulties, the distances they are required to travel, and the limited availability of speech pathologists in their local community. This project aims to overcome these access issues through the development of a telerehabilitation system that will enable speech pathologists to assess people with these speech and language difficulties across the Internet using videoconferencing. It is intended that this research will ultimately enable people with these types of communication difficulties to be assessed and treated within their own home or local community.Read moreRead less