The Darwin Prospective Melioidosis Study: Years 27-31
Funder
National Health and Medical Research Council
Funding Amount
$1,281,718.00
Summary
The Darwin Prospective Melioidosis Study has documented 914 cases since 1989, with 115 fatalities. A surge in Darwin melioidosis cases over the past 5 years has been linked to urban development and the discovery of a new bacterial strain. Whole genome sequencing of our unique 25+ year set of bacteria and their linked patient data will unravel the changing epidemiology and identify important virulence factors, forming a foundation for future diagnostics, therapeutics, and vaccines.
Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying ....Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying regulators of lipid metabolism. The large diversity in humans necessitate sufficient sample sizes to identify true genetic regulators, but to date techniques capturing phenotypic data (lipids) have been largely limited. It is anticipated that this study will identify new regulators of lipid metabolism in humans.Read moreRead less
Linking Genomics Of Burkholderia Pseudomallei To Melioidosis: Diversity Of Clinical Manifestations, Changing Epidemiology And Microevolution In Chronic Carriage.
Funder
National Health and Medical Research Council
Funding Amount
$602,769.00
Summary
The Darwin Prospective Melioidosis Study has documented 761 cases since 1989, with 102 fatalities. This study has led to improved therapy and public health initiatives. New technology to sequence whole bacterial genomes provides an opportunity to determine why urban melioidosis is increasing and to analyse this unique 22+ year set of bacteria and their linked patient data to find the important bacterial virulence factors, forming a foundation for future diagnostics, therapeutics, and vaccines.
Learning to Talk, Talking to Learn: Effects of an early childhood language program in remote Northern Territory indigenous communities. Both the quality and quantity of language children hear, and adult understandings of child development, drive children's future outcomes. Understanding how to improve both is critical to the lifelong education, employment and social potential of children from low socioeconomic families, especially with hearing loss. This project aims to examine to what extent a ....Learning to Talk, Talking to Learn: Effects of an early childhood language program in remote Northern Territory indigenous communities. Both the quality and quantity of language children hear, and adult understandings of child development, drive children's future outcomes. Understanding how to improve both is critical to the lifelong education, employment and social potential of children from low socioeconomic families, especially with hearing loss. This project aims to examine to what extent a parent-implemented early childhood language program designed to buffer against effects of childhood otitis media can support indigenous children in remote northern Australia. Outcomes aim to be data on effects on children's language, attention, and school readiness, plus uptake of strategies and knowledge by parents and other adults, and evidence regarding best practice in such contexts.Read moreRead less