A Novel Approach To The Training Of Functional Standing Following Spinal Cord Injury
Funder
National Health and Medical Research Council
Funding Amount
$412,706.00
Summary
The study will employ a new type of functional electrical stimulation (FES), strength-endurance muscle conditioning and standing training to improve stance in SCI victims with incomplete paralysis. We will evaluate an innovative combination of muscle training and novel FES protocols which allow paralysed people to stand and perform upper limb functional tasks. The primary outcomes will be duration of standing, number of repetitions of standing and sitting and upper limb function while standing.
Orthostatic Tolerance During FES-evoked Stepping In Paraplegia: A Safety And Viability Study
Funder
National Health and Medical Research Council
Funding Amount
$244,900.00
Summary
In the past 30 years, there has been growing interest in the potential benefits of functional electrical stimulation (FES) of the paralysed leg muscles as a means of restoring movement in the lower limbs. FES uses electrical impulses generated by a stimulator to elicit purposeful muscle contractions via skin-surface electrodes placed over the muscles. Although traditionally limited to health-related activities such as stationary cycling exercise, recent bioengineering advances in the area of FES ....In the past 30 years, there has been growing interest in the potential benefits of functional electrical stimulation (FES) of the paralysed leg muscles as a means of restoring movement in the lower limbs. FES uses electrical impulses generated by a stimulator to elicit purposeful muscle contractions via skin-surface electrodes placed over the muscles. Although traditionally limited to health-related activities such as stationary cycling exercise, recent bioengineering advances in the area of FES present the SCI person with a means of restoring upright mobility and reinstating functional tasks. Yet, while this technological innovation remains promising for optimising functional outcomes after SCI, there remains a distinct lack of knowledge of the physiological stresses placed upon the individual. In this preliminary safety and viability study, the physiological implications central to enhanced upright mobility will be investigated during FES-evoked prolonged stepping. The responses during FES-stepping will be contrasted with the responses observed during stepping performed without FES. The study will investigate the blood pressure responses during FES-gait, but also address possible physiological mechanisms underlying those blood pressure responses. The findings from this study will identify whether there is a phsiological limitation to the performance of FES-evoked functional mobility. Current physiotherapy practice recognises blood pressure control and orthostatic hypotension as a significant barrier to functional standing and stepping, yet little is known about the physiology underpinning the condition. If FES does present a limitation to the performance of upright functional activities, this study will also assist in devising alternative physiotherapy gait training regimens.Read moreRead less
Transcutaneous Electrical Stimulation To Relieve Chronic Constipation In Children
Funder
National Health and Medical Research Council
Funding Amount
$82,450.00
Summary
1 in 300 children suffer from chronic constipation that is not fixed by changing their diet or taking laxatives. They continue to suffer the problem into adulthood. They also have fecal incontinence or soiling that causes problems with socialising and schooling. We are testing a method of electrical stimulation through the skin on the belly to increase the movement of the bowel. Initial results are encouraging, showing that the rate of movement of the bowel is increased and soiling is decreased.
Transcutaneous Electrical Stimulation To Relieve Chronic Constipation In Children
Funder
National Health and Medical Research Council
Funding Amount
$346,995.00
Summary
We have over 300 children with chronic treatment-resistant constipation at Royal Children's Hospital Melbourne. We have a new physiotherapy technique that may overcome constipation and stop soiling in many of these children. In 2003-4, we ran a pilot study to test a technique used by physiotherapists to treat urinary incontinence. We have called the method TESIC (transcutaneous electrical stimulation using interferential current). TESIC uses suction electrodes placed on the belly and back at the ....We have over 300 children with chronic treatment-resistant constipation at Royal Children's Hospital Melbourne. We have a new physiotherapy technique that may overcome constipation and stop soiling in many of these children. In 2003-4, we ran a pilot study to test a technique used by physiotherapists to treat urinary incontinence. We have called the method TESIC (transcutaneous electrical stimulation using interferential current). TESIC uses suction electrodes placed on the belly and back at the level of the belly button. The electrical stimulation is applied using a current (interferential current) that stimulates deep into the abdomen. We tested 8 children and had very encouraging results with improved constipatio in 5-8 and all with soiling stopped. Parents and children are keen to use this technique but first we need to establish that the results are reproducible in a larger group of 70 children. We also need to know if the effect was just a placebo response (due to time spent with the physiotherapists), and how long the effect lasts. We will also measure changes in soiling. Faecal soiling is smelly and antisocial. Relief of soiling has a big impact on a child's ability to fit in at school and to attend normal schooling. We will measure outcomes using daily diaries kept by children, questionnaires, how quickly food moves through the bowel and pressures within the bowel. We have a multidiciplinary team of experienced clinicians and scientists with expertise in these techniques and in constipation and incontinence in children (paediatric surgeon, gastroenterologist, manometry nurse, incontinence paediatrician and physiotherapist, expert in electrical stimulation and gut nervous system scientist). This technique could revolutionise treatment of chronic constipation. Most physiotherapists have TESIC machines, allowing delivery Australia wide. It is non-invasive and should also be able to be used by adults, including the elderly in nursing homes.Read moreRead less
Characterising And Modulating Corticostriatal Connectivity In Schizophrenia.
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
Schizophrenia is a devastating mental illness that affects approximately 0.5-1% of the population. Many of the symptoms of schizophrenia, such as problems with memory and motivation, remain untreatable. This project will explore the brain processes that underlie memory deficits in people with schizophrenia and investigate the use of non-invasive brain stimulation to improve these impairments. The results from this study will hopefully lead to new treatments for people with schizophrenia.
Investigation Of The Effect Of Prism Therapy On Attention Dysfunction In Right-parietal Lobe Damaged Stroke Patients With Spatial Neglect.
Funder
National Health and Medical Research Council
Funding Amount
$343,888.00
Summary
A strong predictor of a bad outcome after stroke is spatial neglect. This condition is due to a deficit in attention. With attention shifted towards the undamaged side, the victim ignores their damaged side. A new therapy improves neglect, yet little is known about how brain circuits are altered with therapy. We will identify brain areas critical in restoring normal attention, and will investigate for the first time whether repeated therapy sessions improve treatment effectiveness.
Improved Perception Of Temporal Information In Electrical Signals For Profoundly Deaf Users Of Cochlear Implants
Funder
National Health and Medical Research Council
Funding Amount
$170,440.00
Summary
The ultimate goal of this project is to improve the ability of cochlear implant users to understand speech. The way in which a speech signal varies in amplitude over time provides useful information to the listener about the content of the speech signal. Currently, the way that the acoustic signal amplitude is converted to electrical signal amplitude for cochlear implantees does not take into consideration the very significant loudness summation present in multiple-electrode electrical stimulati ....The ultimate goal of this project is to improve the ability of cochlear implant users to understand speech. The way in which a speech signal varies in amplitude over time provides useful information to the listener about the content of the speech signal. Currently, the way that the acoustic signal amplitude is converted to electrical signal amplitude for cochlear implantees does not take into consideration the very significant loudness summation present in multiple-electrode electrical stimulation. That is, when there are multiple sequential current pulses on different electrodes over a short time, the resultant loudness is greater than the loudness due to individual current pulses. The lack of consideration of loudness summation effects has led to the amplitude variations in the acoustic signal not being accurately represented in the loudness variation perceived by the cochlear implantee. This project aims to develop a practical way of more accurately representing speech signal amplitude fluctuations for cochlear implantees by studying the effects of loudness summation. A second aim of the project is to study the effects on perception of using differently-shaped current pulses from those currently used. There is evidence from physiology experiments that using different shapes might cause the electrical stimulation to activate a more narrowly-spaced set of auditory neurons for each electrode. The application of results of both these studies will lead directly to improved perception of speech and other sounds by cochlear implantees, thus improving their communication ability and quality of life.Read moreRead less
Investigating Caloric Vestibular Stimulation As A Novel Therapeutic Intervention For Chronic Pain, Mania And Depression.
Funder
National Health and Medical Research Council
Funding Amount
$340,963.00
Summary
Chronic pain, mania and depression are common health problems worldwide and represent an enormous burden of illness. Current treatments may be costly, invasive and have serious side-effects. In the proposed project, demonstration of therapeutic benefit with a novel, simple method of brain stimulation without such limitations could change how these disorders are managed. Moreover, the findings would be of substantial significance in developing countries where treatments are often non-existent.
NEURONAL RESPONSES ELICITED BY VIEWING HUMAN BODY MOTION AND GESTURE.
Funder
National Health and Medical Research Council
Funding Amount
$135,822.00
Summary
This project aims to study human brain regions active in viewing movements of the body, face and hands, as well as gestures (i.e. movements with meaning). We will map the location of these human motion sensitive brain regions relative to brain areas dealing with other visual functions. We will use a new method of brain scanning (functional MRI) and recordings of the electrical activity of the brain to achieve these goals. Subjects for this project will be epilepsy patients undergoing investigati ....This project aims to study human brain regions active in viewing movements of the body, face and hands, as well as gestures (i.e. movements with meaning). We will map the location of these human motion sensitive brain regions relative to brain areas dealing with other visual functions. We will use a new method of brain scanning (functional MRI) and recordings of the electrical activity of the brain to achieve these goals. Subjects for this project will be epilepsy patients undergoing investigation for seizure surgery at the A and RMC and Royal Children's Hospitals in Melbourne. Functional MRI - a new non-invasive method for studying brain function - will locate the brain structures involved in the detection and analysis of human motion. Recording electrodes are surgically placed inside the brains of these patients in order to find the source of their seizures, and these electrodes will be utilised for this study. A number of facial, hand and body movement and gestural stimuli will be used. First, brain locations responding to face, hand and body movements will be identified. It is predicted that regions sensitive to hand motion could be located near areas known to participate in adjusting the subject's own visually-guided reaching behaviour. Similarly, regions sensitive to facial motion could be located near areas thought to deal with lip-reading. Second, differences in brain activity to gestures and movements of the face and hand will be studied, so as identify brain regions that process increasingly complex information. Third, differences in brain responses to incompatible (e.g. head facing left and moving right) versus compatible human motion will be studied. A brain 'map' with locations of these human motion sensitive regions relative to visually sensitive regions will be generated. These data will not only aid planning for future seizure surgery, but have implications for our understanding of the visual aspects of motor apraxia.Read moreRead less
Fatigue in Lead-free Piezoceramics. This project aims are to achieve a fundamental understanding of the fatigue behaviour of lead-free piezoelectric ceramics which achieve high strain through phase transformations and then ascertain the effects of this behaviour on material degradation rates. The expected outcomes will facilitate replacement of toxic lead in commodity electronics. The focus will be on new lead-free bismuth-alkali-based piezoelectric ceramic systems which demonstrate exciting pot ....Fatigue in Lead-free Piezoceramics. This project aims are to achieve a fundamental understanding of the fatigue behaviour of lead-free piezoelectric ceramics which achieve high strain through phase transformations and then ascertain the effects of this behaviour on material degradation rates. The expected outcomes will facilitate replacement of toxic lead in commodity electronics. The focus will be on new lead-free bismuth-alkali-based piezoelectric ceramic systems which demonstrate exciting potential as alternate materials to lead zirconate titanate (PZT) materials. Successful optimisation of the materials' design and knowledge of their degradation rates are expected to facilitate their commercialisation through a profound reduction in the environmental challenges associated with manufacture and disposal of devices.Read moreRead less