Optimising Efficacy Of A Peptide Derived Against The Alpha-interacting Domain Of The L-type Calcium Channel In Reduction Of Ischemia-reperfusion Injury
Funder
National Health and Medical Research Council
Funding Amount
$405,063.00
Summary
A heart attack is associated with an increase in free radicals and calcium in heart muscle cells. The function of the L-type calcium channel, a protein responsible for calcium entry into cells, is altered by free radicals and this contributes to the development of heart disease. We now have considerable proof of concept that a peptide derived against the L-type calcium channel can decrease heart injury. We will optimise efficacy and delivery of the peptide to prevent heart failure.
Role Of Sensory Neurons In Obstruction-induced Bladder Overactivity
Funder
National Health and Medical Research Council
Funding Amount
$340,986.00
Summary
About 20% of people over the age of 40 have the clinical syndrome of an “overactive bladder”, which causes symptoms of urgency, frequency and incontinence. The mechanisms causing bladder overactivity are not known. This project will identify sensory neurons, which become overexcited, and determine which mediators and ionic channels are responsible for this. Our new data will identify selective pharmacological targets for new therapies and diagnostic tools for these distressing bladder disorders.