Radical redox indicators. This project aims to synthesise the first examples of advanced biological imaging agents that can reversibly respond to the oxidative status of living cells. Novel mitochondrially-targeted, fluorescent probes will be derived from several well-established families of biological dyes through the introduction of a stable free radical within the parent structure. The design of the new imaging agents aims to both enhance retention in, and restrict the fluorescence response t ....Radical redox indicators. This project aims to synthesise the first examples of advanced biological imaging agents that can reversibly respond to the oxidative status of living cells. Novel mitochondrially-targeted, fluorescent probes will be derived from several well-established families of biological dyes through the introduction of a stable free radical within the parent structure. The design of the new imaging agents aims to both enhance retention in, and restrict the fluorescence response to, the mitochondria so that changes in oxidation and reduction can be monitored. The probes will provide an innovative new means to assess reactive species and associated oxidative stress, thus delivering a new methodology to aid research into mitochondrial chemical biology.Read moreRead less
Fighting slime with free radicals - new surface coatings for biofilm remediation. Bacterial biofilms are a major problem in a number of environmental, industrial and medical applications. They cause significant risks to human health and present an enormous economic burden to society. This project aims to develop smart polymeric coatings that will discourage bacterial attachment and ensure greater long term control over biofilm growth. These coatings represent a breakthrough in the field and will ....Fighting slime with free radicals - new surface coatings for biofilm remediation. Bacterial biofilms are a major problem in a number of environmental, industrial and medical applications. They cause significant risks to human health and present an enormous economic burden to society. This project aims to develop smart polymeric coatings that will discourage bacterial attachment and ensure greater long term control over biofilm growth. These coatings represent a breakthrough in the field and will have a profound impact in many areas, including reducing infections related to medical implants and improving the efficiency of marine engineering systems.Read moreRead less
A Fundamental study into the role of the organic fraction on the toxicity of combustion generated airborne particles. Using a new set of analytical tools this project will for the first time allow a quantified measure of the toxicity of organic compounds condensed on the surface of airborne particles. Understanding the toxicity of particle pollution is essential in controlling the exposure risk to public health.
Eradicating bacterial biofilms with nitroxide-antimicrobial hybrids. This project aims to develop new antimicrobials to address the rise of drug-resistant infections and resilient bacterial communities called biofilms. We aim to break new ground in our fundamental knowledge of antimicrobial mechanisms and exploit this understanding by fusing cellular/molecular microbiology and synthetic chemistry approaches. We seek to gain an in-depth understanding of how nitroxides induce bacterial biofilm dis ....Eradicating bacterial biofilms with nitroxide-antimicrobial hybrids. This project aims to develop new antimicrobials to address the rise of drug-resistant infections and resilient bacterial communities called biofilms. We aim to break new ground in our fundamental knowledge of antimicrobial mechanisms and exploit this understanding by fusing cellular/molecular microbiology and synthetic chemistry approaches. We seek to gain an in-depth understanding of how nitroxides induce bacterial biofilm dispersal, which is critical for the discovery of anti-biofilm molecules that do not fail due to resistance development. These breakthroughs should induce a step-change in our ability to reduce the occurrence of biofilm-related infection in fields ranging from medical and veterinary to biotechnology and agriculture.Read moreRead less
Nitroxide-containing scaffolds for controlling biofilm-related infections. Bacterial biofilms are a major problem in healthcare systems around the world as they cause persistent and chronic infections, including those associated with medical implants and cystic fibrosis. This project aims to develop new chemical approaches to deliver nitroxides at surface interfaces and in microparticles to facilitate long term control over biofilm growth. It is expected that these functionalised scaffolds will ....Nitroxide-containing scaffolds for controlling biofilm-related infections. Bacterial biofilms are a major problem in healthcare systems around the world as they cause persistent and chronic infections, including those associated with medical implants and cystic fibrosis. This project aims to develop new chemical approaches to deliver nitroxides at surface interfaces and in microparticles to facilitate long term control over biofilm growth. It is expected that these functionalised scaffolds will represent a breakthrough in the field and will have a profound impact by reducing infection rates associated with medical devices and improving airway clearance in cystic fibrosis patients.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100061
Funder
Australian Research Council
Funding Amount
$710,000.00
Summary
Extending frontiers of structural chemistry and biology through high resolution pulsed Electron Paramagnetic Resonance. Multifrequency high resolution pulsed Electron Paramagnetic Resonance (EPR) instrumentation will provide forefront technologies in identifying, characterising, quantifying and visualising free radicals and metal ions that are involved in fundamental chemical and biological processes in science and nature.
A Phase III Trial Comparing Adjuvant Versus Salvage Radiotherapy For High Risk Patients Post Radical Prostatectomy
Funder
National Health and Medical Research Council
Funding Amount
$819,138.00
Summary
About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.
Development of New Materials Based on Multinuclear Ruthenium Complexes. The program aims to design new materials for use in applications such as catalysis and light-activated devices (including light harvesting or solar energy conversion), for the detection and analysis of specific small molecules and anions of particular interest, and to provide an insight to the operation of biological systems such as metal-containing enzymes. The particular molecules will also be investigated for the developm ....Development of New Materials Based on Multinuclear Ruthenium Complexes. The program aims to design new materials for use in applications such as catalysis and light-activated devices (including light harvesting or solar energy conversion), for the detection and analysis of specific small molecules and anions of particular interest, and to provide an insight to the operation of biological systems such as metal-containing enzymes. The particular molecules will also be investigated for the development of a new type of therapeutic agent for the treatment of a range of diseases, with a particular interest in this work on a drug for the treatment of HIV-AIDS. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100197
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
National magnetochemical facility. New magnetic materials of the molecular or biological types are quite different to traditional metal oxide magnets widely used, for example, in recording devices. They are very important from the perspective of understanding fundamental properties at low temperatures, in high magnetic fields, or when irradiated by light, but they are also showing promise in a range of applications, such as memory devices and smart cards and in the new area of spintronics and m ....National magnetochemical facility. New magnetic materials of the molecular or biological types are quite different to traditional metal oxide magnets widely used, for example, in recording devices. They are very important from the perspective of understanding fundamental properties at low temperatures, in high magnetic fields, or when irradiated by light, but they are also showing promise in a range of applications, such as memory devices and smart cards and in the new area of spintronics and molecular computers. The magnetochemical projects described here, that require the new equipment being sought, are fundamental in nature but will provide the underpinning of future nanomagnetic materials.Read moreRead less