Little evidence supports interventions to improve mobility outcomes in frail older adults hospitalised for movement rehabilitation. This large randomised controlled trial investigates whether increasing the amount of physical activity during inpatient rehabilitation improves mobility and is cost effective. Frail older Australians are very high users of health services. This study will provide evidence for intensive physical therapy that is easily delivered, with significant benefits to older adu ....Little evidence supports interventions to improve mobility outcomes in frail older adults hospitalised for movement rehabilitation. This large randomised controlled trial investigates whether increasing the amount of physical activity during inpatient rehabilitation improves mobility and is cost effective. Frail older Australians are very high users of health services. This study will provide evidence for intensive physical therapy that is easily delivered, with significant benefits to older adults and the aged care health system.Read moreRead less
Risk Stratification Of Older People In Hospital: Validation And Influence On Clinical Decision Making
Funder
National Health and Medical Research Council
Funding Amount
$291,067.00
Summary
Older people in hospital are at high risk of adverse outcomes, a vulnerability commonly referred to as frailty. In community-dwelling older people, frailty status can be measured precisely with a Frailty Index score. This research aims to develop a Frailty Index from a standardised comprehensive geriatric assessment instrument used in the routine care of many patients in hospital. This would assist clinicians to identify vulnerable older inpatients, improving their care in the acute setting.
Reaching The Tenth Decade Of Life In Australia – A 20-year Longitudinal Study Of Older Men
Funder
National Health and Medical Research Council
Funding Amount
$890,063.00
Summary
There are increasing numbers of older people in Australia. A boy born in Australia in 2015 may expect to live to 92 years but how we will ensure that the health of these older men is maintained, and that ageing is a positive experience, is not yet known. We will study a large group of men initially aged over 65 years of age, and who have already been followed for 20 years, to work out how Australian men can reach the tenth decade of life, and how they can achieve this milestone successfully. .
Investigating Hippo Signalling As A Novel Cause Of Muscle Disease, And As A Target For New Interventions To Combat Frailty
Funder
National Health and Medical Research Council
Funding Amount
$460,509.00
Summary
We will explore the role of the Hippo signaling pathway in muscle development, repair and remodelling. We propose that this little-known pathway which affects organ development, is key for maintaining healthy muscles, and is affected in muscle wasting. Using gene therapy tools to alter this pathway in models of disease, we intend to clarify the role of Hippo signaling in muscle, and establish whether the pathway can be manipulated to treat physical frailty caused by muscle wasting.