Drugs are applied to the skin for the treatment of a wide range of conditions, including both local (eg. inflammation, muscle pain, eczema, psoriasis and other dermatological conditions) and systemic (eg. angina, hormone replacement, nicotine withdrawal) therapies. Advances in molecular biology technology has also led to the development of a range of large molecular weight peptide and protein based therapeutic agents for which transdermal delivery offers the most cost-effective and practical sol ....Drugs are applied to the skin for the treatment of a wide range of conditions, including both local (eg. inflammation, muscle pain, eczema, psoriasis and other dermatological conditions) and systemic (eg. angina, hormone replacement, nicotine withdrawal) therapies. Advances in molecular biology technology has also led to the development of a range of large molecular weight peptide and protein based therapeutic agents for which transdermal delivery offers the most cost-effective and practical solution if appropriate delivery systems can be identified. In addition, unwanted skin absorption also occurs following exposure to environmental occupational chemicals, and those applied deliberately to the skin such as insecticides, sunscreens and cosmetics. This study continues our work in seeking to define the relationship between the chemical structure of agents, the types of formulations and solvents in which they are applied or come into contact with the skin and their penetration, distribution and retention in the various layers of the skin and underlying tissues. Of great significance to both the pharmaceutical industry and risk assessment regulatory bodies will be the further development of our work into important areas relating to the ability to predict the likely behaviour of a solute following contact with the skin from the aspect of both optimising drug delivery systems and the accuracy of risk assessment procedures. We will also be continuing our work examining techniques to facilitate drug transport through the skin using physical techniques such as iontophoresis and the design of formulations to specifically target larger pores in the skin such as hair follicles as a means of improving delivery rates and increasing the range of solutes, particularly those of large molecular weight, likely to be considered as potential drug candidates.Read moreRead less
Platform Nanotechnologies For Oral Delivery Of Drugs, Therapeutic Protein And Peptide Delivery
Funder
National Health and Medical Research Council
Funding Amount
$437,034.00
Summary
The development of reliable oral delivery systems for problem drugs and biologics is one of the biggest challenges faced by the pharmaceutical industry in recent times. In order to tackle these challenges, I have developed programmable nanoparticles capable of efficiently deliver wide range of drugs including large peptides and proteins orally.
Novel Prolonged-release Polymeric Microparticles For Relief Of Intractable Cancer-related Pain
Funder
National Health and Medical Research Council
Funding Amount
$796,950.00
Summary
For the 10-30% of patients with advanced cancer who experience intractable pain despite administration of large doses of morphine-like drugs by mouth or injection, more invasive dosing routes may be needed. This project will utilise innovative polymer chemistry to develop bioerodable prolonged-release polymer microparticles to deliver pain-killers into the spinal fluid near to the cells that mediate their actions, with a view to producing prolonged periods of analgesia in these patients.
Drugs are applied to the skin for the treatment of a wide range of conditions including both local (inflammation, pain, eczema, psoriasis) and systemic (angina, nicotine withdrawl, hormone replacement therapy) therapies. Unwanted skin absorption also occurs following exposure to environmental and occupational chemicals, including those applied deliberately to the skin such as insectisides, sunscreens and cosmetics. This study seeks to examine the relationship between the chemical structure of ag ....Drugs are applied to the skin for the treatment of a wide range of conditions including both local (inflammation, pain, eczema, psoriasis) and systemic (angina, nicotine withdrawl, hormone replacement therapy) therapies. Unwanted skin absorption also occurs following exposure to environmental and occupational chemicals, including those applied deliberately to the skin such as insectisides, sunscreens and cosmetics. This study seeks to examine the relationship between the chemical structure of agents, the types of formulations in which they are applied and their penetration into the various layers of the skin and underlying tissues. We intend to further our research into important areas relating to the ability to predict the likely behaviour of a solute which comes into contact with the skin from the aspect of optimising both topical drug delivery systems and risk assessment procedures. We will also be examining techniques of facilitating drug transport through the skin using (i) the knowledge gained of the mechanisms by which vehicles act on the skin, (ii) the synthesis of ester and amide lipophilic prodrugs and (iii) physical techniques such as iontophoresis, whereby small electrical currents are applied to charged drug species on the outside of the skin.Read moreRead less
Bioresponsive Nanocarriers For Controlled And Targeted Delivery To Efficiently Treat Inflammatory Bowel Disease (IBD)
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
Despite considerable progress in treatment of Inflammatory Bowel Diseases, current treatments suffer from many disadvantages such as side effects, lack of efficacy in many patients, and development of drug dependence. Using state of art nanotechnology, novel nanoparticles will be developed to enhance the delivery to the intestine and efficacy of Budesonide (an anti-inflammatory steroid). This research promises to find safer and more effective ways to treat these diseases.
Discovery Early Career Researcher Award - Grant ID: DE190100113
Funder
Australian Research Council
Funding Amount
$420,437.00
Summary
Interactions between volumetric units in modular buildings. This project aims to develop an in-depth understanding of the interactions between volumetric units in modular buildings to develop integration strategies for the interconnection of modules. The uptake of modular construction has been hindered by the technical complexities of the design process for manufacture and assembly, in particular the flexible connection of services. By addressing significant gaps in the guidance on the design of ....Interactions between volumetric units in modular buildings. This project aims to develop an in-depth understanding of the interactions between volumetric units in modular buildings to develop integration strategies for the interconnection of modules. The uptake of modular construction has been hindered by the technical complexities of the design process for manufacture and assembly, in particular the flexible connection of services. By addressing significant gaps in the guidance on the design of modular interconnections and their integration strategies, this project expects to enhance the industry’s capacity to adopt safe, economical and standardised designs of modular systems. This project should significantly reduce the risk in decision making in modular construction, and transformation to advanced building manufacturing technologies in Australia and beyond.Read moreRead less
Surfacing urban wetlands in two urban renewal sites in Sydney. Urban wetlands in Australia provide benefits for climate change mitigation, pollution reduction, habitat provision and socioecological connection. However, in large cities like Sydney, urban wetlands are unseen because undergrounded, and, therefore not adequately understood. This illegibility, and loss of understanding by residents, planners and policy makers impedes wetlands' good management. This project surfaces wetlands through v ....Surfacing urban wetlands in two urban renewal sites in Sydney. Urban wetlands in Australia provide benefits for climate change mitigation, pollution reduction, habitat provision and socioecological connection. However, in large cities like Sydney, urban wetlands are unseen because undergrounded, and, therefore not adequately understood. This illegibility, and loss of understanding by residents, planners and policy makers impedes wetlands' good management. This project surfaces wetlands through visualisation in a multimodal knowledge platform focusing on two urban renewal sites, Green Square and Marrickville South. We leverage design ethnography to develop resources for strengthening multiple stakeholders’ socioecological engagement through methods empowering just, creative and open participation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100161
Funder
Australian Research Council
Funding Amount
$407,598.00
Summary
Translational Design: Product Development for Research Commercialisation. Australia is a world leader in fundamental research. Yet, ranks as one of the worst developed nations for translating research into new-to-market innovation. This project explores a new role for design as a critical component of research commercialisation and innovation ecosystems. It expects to contribute novel insights into how designers can be better integrated into interdisciplinary research directed towards commercial ....Translational Design: Product Development for Research Commercialisation. Australia is a world leader in fundamental research. Yet, ranks as one of the worst developed nations for translating research into new-to-market innovation. This project explores a new role for design as a critical component of research commercialisation and innovation ecosystems. It expects to contribute novel insights into how designers can be better integrated into interdisciplinary research directed towards commercial outcomes. Expected outcomes include a framework and toolkit for a paradigm-shifting design approach to translating fundamental research into products commercialised and manufactured in Australia. This should provide enhanced economic benefit, building Australia’s sovereign capability in new-to-market innovation.Read moreRead less
Using acoustic retroreflection in architecture to improve rooms for speech. This project aims to discover how a novel form of acoustic treatment can improve acoustics for speech in rooms such as classrooms and open-plan offices. The project will generate new knowledge on the theory, design, and effects of acoustically retroreflective surfaces in room acoustics. Expected outcomes include solutions for effective acoustic retroreflectors, knowledge on how retroreflection influences people’s voice r ....Using acoustic retroreflection in architecture to improve rooms for speech. This project aims to discover how a novel form of acoustic treatment can improve acoustics for speech in rooms such as classrooms and open-plan offices. The project will generate new knowledge on the theory, design, and effects of acoustically retroreflective surfaces in room acoustics. Expected outcomes include solutions for effective acoustic retroreflectors, knowledge on how retroreflection influences people’s voice regulation and sound quality perception, and guidelines and simulation tools for integrating retroreflective treatments to improve speaking comfort. This should provide significant benefits including opportunities to resolve seemingly intractable design dilemmas in the acoustics of education and workplace environments.Read moreRead less