Drugs are applied to the skin for the treatment of a wide range of conditions, including both local (eg. inflammation, muscle pain, eczema, psoriasis and other dermatological conditions) and systemic (eg. angina, hormone replacement, nicotine withdrawal) therapies. Advances in molecular biology technology has also led to the development of a range of large molecular weight peptide and protein based therapeutic agents for which transdermal delivery offers the most cost-effective and practical sol ....Drugs are applied to the skin for the treatment of a wide range of conditions, including both local (eg. inflammation, muscle pain, eczema, psoriasis and other dermatological conditions) and systemic (eg. angina, hormone replacement, nicotine withdrawal) therapies. Advances in molecular biology technology has also led to the development of a range of large molecular weight peptide and protein based therapeutic agents for which transdermal delivery offers the most cost-effective and practical solution if appropriate delivery systems can be identified. In addition, unwanted skin absorption also occurs following exposure to environmental occupational chemicals, and those applied deliberately to the skin such as insecticides, sunscreens and cosmetics. This study continues our work in seeking to define the relationship between the chemical structure of agents, the types of formulations and solvents in which they are applied or come into contact with the skin and their penetration, distribution and retention in the various layers of the skin and underlying tissues. Of great significance to both the pharmaceutical industry and risk assessment regulatory bodies will be the further development of our work into important areas relating to the ability to predict the likely behaviour of a solute following contact with the skin from the aspect of both optimising drug delivery systems and the accuracy of risk assessment procedures. We will also be continuing our work examining techniques to facilitate drug transport through the skin using physical techniques such as iontophoresis and the design of formulations to specifically target larger pores in the skin such as hair follicles as a means of improving delivery rates and increasing the range of solutes, particularly those of large molecular weight, likely to be considered as potential drug candidates.Read moreRead less
Platform Nanotechnologies For Oral Delivery Of Drugs, Therapeutic Protein And Peptide Delivery
Funder
National Health and Medical Research Council
Funding Amount
$437,034.00
Summary
The development of reliable oral delivery systems for problem drugs and biologics is one of the biggest challenges faced by the pharmaceutical industry in recent times. In order to tackle these challenges, I have developed programmable nanoparticles capable of efficiently deliver wide range of drugs including large peptides and proteins orally.
Novel Prolonged-release Polymeric Microparticles For Relief Of Intractable Cancer-related Pain
Funder
National Health and Medical Research Council
Funding Amount
$796,950.00
Summary
For the 10-30% of patients with advanced cancer who experience intractable pain despite administration of large doses of morphine-like drugs by mouth or injection, more invasive dosing routes may be needed. This project will utilise innovative polymer chemistry to develop bioerodable prolonged-release polymer microparticles to deliver pain-killers into the spinal fluid near to the cells that mediate their actions, with a view to producing prolonged periods of analgesia in these patients.
Drugs are applied to the skin for the treatment of a wide range of conditions including both local (inflammation, pain, eczema, psoriasis) and systemic (angina, nicotine withdrawl, hormone replacement therapy) therapies. Unwanted skin absorption also occurs following exposure to environmental and occupational chemicals, including those applied deliberately to the skin such as insectisides, sunscreens and cosmetics. This study seeks to examine the relationship between the chemical structure of ag ....Drugs are applied to the skin for the treatment of a wide range of conditions including both local (inflammation, pain, eczema, psoriasis) and systemic (angina, nicotine withdrawl, hormone replacement therapy) therapies. Unwanted skin absorption also occurs following exposure to environmental and occupational chemicals, including those applied deliberately to the skin such as insectisides, sunscreens and cosmetics. This study seeks to examine the relationship between the chemical structure of agents, the types of formulations in which they are applied and their penetration into the various layers of the skin and underlying tissues. We intend to further our research into important areas relating to the ability to predict the likely behaviour of a solute which comes into contact with the skin from the aspect of optimising both topical drug delivery systems and risk assessment procedures. We will also be examining techniques of facilitating drug transport through the skin using (i) the knowledge gained of the mechanisms by which vehicles act on the skin, (ii) the synthesis of ester and amide lipophilic prodrugs and (iii) physical techniques such as iontophoresis, whereby small electrical currents are applied to charged drug species on the outside of the skin.Read moreRead less
Bioresponsive Nanocarriers For Controlled And Targeted Delivery To Efficiently Treat Inflammatory Bowel Disease (IBD)
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
Despite considerable progress in treatment of Inflammatory Bowel Diseases, current treatments suffer from many disadvantages such as side effects, lack of efficacy in many patients, and development of drug dependence. Using state of art nanotechnology, novel nanoparticles will be developed to enhance the delivery to the intestine and efficacy of Budesonide (an anti-inflammatory steroid). This research promises to find safer and more effective ways to treat these diseases.
Designing for wellbeing: realizing benefits for patients through best practice hospital design. The environmental design of healthcare facilities has been shown to directly affect the wellbeing of patients and their families. Poorly designed environments exacerbate patient anxiety and stress and diminish their healthcare experience. Environments designed to support a patient’s wellbeing result in improved health outcomes. Building upon Australia’s international leadership in contemporary hospita ....Designing for wellbeing: realizing benefits for patients through best practice hospital design. The environmental design of healthcare facilities has been shown to directly affect the wellbeing of patients and their families. Poorly designed environments exacerbate patient anxiety and stress and diminish their healthcare experience. Environments designed to support a patient’s wellbeing result in improved health outcomes. Building upon Australia’s international leadership in contemporary hospital design, this project aims to evaluate, prioritise and strategise the best means for realising benefits of environmental design factors that contribute most significantly to achieving positive outcomes for patients and families. It aims to achieve this through a comprehensive comparative case study analysis of new Australian paediatric hospitals.Read moreRead less
Digital fabrication technologies: analysing patterns of adoption and innovative transformations in architectural design and practice. This project on adoption of digital fabrication technologies by Australian architecture practices will reveal emerging opportunities for creative design and associated transformations in the design practices. These outcomes will enable the increasingly globalising sector of architectural design services to become more agile and innovative.
Collapse assessment of reinforced concrete buildings in regions of lower seismicity. This research aims to develop a new displacement based (DB) method for regions of lower seismicity, using 'Displacement Controlled' phenomenon, to assess the risk of collapse and seismic performance of buildings. The project will investigate the system behaviour of buildings in Australia that are laterally supported by lightly reinforced concrete geometric walls, including both torsional and wall floor interacti ....Collapse assessment of reinforced concrete buildings in regions of lower seismicity. This research aims to develop a new displacement based (DB) method for regions of lower seismicity, using 'Displacement Controlled' phenomenon, to assess the risk of collapse and seismic performance of buildings. The project will investigate the system behaviour of buildings in Australia that are laterally supported by lightly reinforced concrete geometric walls, including both torsional and wall floor interaction effects. The new DB method could allow buildings in regions of lower seismicity to be designed for robustness, gravity and wind loading and then checked using displacement principles for seismic compliance, which will dramatically simplify and improve the current seismic design process.Read moreRead less
Built-up cold-formed steel structures. The building industry is seeing a rapid uptake of joining two or more cold-formed steel sections to form large built-up sections with high carrying capacities. The joining consists of screws, or similar fasteners, placed intermittently along the member. The ease of joining encourages innovation in forming versatile new built-up section shapes in expanding areas of application. The project will provide guidelines and numerical tools for the efficient structu ....Built-up cold-formed steel structures. The building industry is seeing a rapid uptake of joining two or more cold-formed steel sections to form large built-up sections with high carrying capacities. The joining consists of screws, or similar fasteners, placed intermittently along the member. The ease of joining encourages innovation in forming versatile new built-up section shapes in expanding areas of application. The project will provide guidelines and numerical tools for the efficient structural design of built-up sections through experimental and theoretical research, studying the new failure modes pertaining to built-up sections, the increase in strength achievable from composite action and the optimum arrangement of fasteners. Read moreRead less