Intracortical inhibition evaluated by paired-pulse TMS during choice and simple reaction time tasks. The research will investigate the neurophysiological processes responsible for the selection and initiation of movement in response to an external stimulus. Slowness in the initiation and execution of movement is a common feature of 'neurological aging', neurodegenerative disease, and brain injury. Understanding the brain mechanisms involved in response selection and movement initiation will pro ....Intracortical inhibition evaluated by paired-pulse TMS during choice and simple reaction time tasks. The research will investigate the neurophysiological processes responsible for the selection and initiation of movement in response to an external stimulus. Slowness in the initiation and execution of movement is a common feature of 'neurological aging', neurodegenerative disease, and brain injury. Understanding the brain mechanisms involved in response selection and movement initiation will provide information for the development of specific intervention techniques to improve motor function in these groups.Read moreRead less
The role of the Supplementary Motor Area in time processing. The neural bases of timing mechanisms (0.1-100s range) are the subject of much debate. We hypothesise that the Supplementary Motor Area (SMA), a major cortical structure involving important dopaminergic pathways, subtends duration encoding, in the way depicted by the 'accumulator model'. Using transcranial magnetic stimulation (TMS) over the SMA, we will test healthy subjects in motor and perceptual timing tasks, compared to Parkinson' ....The role of the Supplementary Motor Area in time processing. The neural bases of timing mechanisms (0.1-100s range) are the subject of much debate. We hypothesise that the Supplementary Motor Area (SMA), a major cortical structure involving important dopaminergic pathways, subtends duration encoding, in the way depicted by the 'accumulator model'. Using transcranial magnetic stimulation (TMS) over the SMA, we will test healthy subjects in motor and perceptual timing tasks, compared to Parkinson's disease patients whose timing performance is impaired due to dopaminergic dysfunction. We expect TMS inhibitory effects to induce predictable performance trends, providing support for the accumulator model and the key role of the SMA in timing.Read moreRead less
Expand the capacity of an international multidisciplinary research network focussed on the ethical, legal and social implications of emerging biotechnologies. This project will ensure that Australia plays a central role in international debates and research activities aimed at regulating and facilitating advances in biotechnology. The project will also provide Australian researchers with direct access to key international experts in the field.
The role of turgor in hyphal extension of the Ascomycete Neurospora crassa. Cellular expansion is an absolute necessity during the growth and development of plants and fungi. This process relies heavily upon the accumulation of inorganic ions. Osmotically driven water influx then creates the hydrostatic pressure that underlies the increase in cell volume. Cellular expansion is normally asymmetric and localised in one small region, such as hyphal tip. How does the cell maintain the turgor that dr ....The role of turgor in hyphal extension of the Ascomycete Neurospora crassa. Cellular expansion is an absolute necessity during the growth and development of plants and fungi. This process relies heavily upon the accumulation of inorganic ions. Osmotically driven water influx then creates the hydrostatic pressure that underlies the increase in cell volume. Cellular expansion is normally asymmetric and localised in one small region, such as hyphal tip. How does the cell maintain the turgor that drives expansion? How is expansion controlled spatially? These questions will be addressed in this project by comprehensive study of ion transport processes in a model organism, Neurospora crassa, using osmotic sensitive and transport mutants.Read moreRead less
From developmental stability to organismic senility: Hox genes and telomere impact on life history evolution. Australia benefits from training researchers and technicians in new, break-through biotechnology and from applying this knowledge to relevant, cutting-edge questions in highly publicized research fields. This project contains both these ingredients. Our model species (a lizard) has a relatively high level of offspring malformations (ca 15%), which makes it much more likely to detect thei ....From developmental stability to organismic senility: Hox genes and telomere impact on life history evolution. Australia benefits from training researchers and technicians in new, break-through biotechnology and from applying this knowledge to relevant, cutting-edge questions in highly publicized research fields. This project contains both these ingredients. Our model species (a lizard) has a relatively high level of offspring malformations (ca 15%), which makes it much more likely to detect their underlying genetic mechanism. Furthermore, we can also assess how these animals survive and reproduce in relation to how quickly they age, which can be measured by assessing the shortening of telomeres per unit time. Thus, this collaboration provides an opportunity to train Australian researchers and in that process generate very high profile research.Read moreRead less
Post-invasion trait-mediated indirect interactions: ecological and evolutionary impacts of the invasive European green crab. A multitude of ecological interactions determine the success and impacts of invasive species. We will advance current knowledge of the impacts of invasive European green crabs in Australia by detailing ecological and evolutionary interactions with native molluscs. This information will be useful in understanding the crab's invasion success and impacts on native communiti ....Post-invasion trait-mediated indirect interactions: ecological and evolutionary impacts of the invasive European green crab. A multitude of ecological interactions determine the success and impacts of invasive species. We will advance current knowledge of the impacts of invasive European green crabs in Australia by detailing ecological and evolutionary interactions with native molluscs. This information will be useful in understanding the crab's invasion success and impacts on native communities in Australia and other regions invaded by the crab worldwide. More broadly, this work will provide an evolutionary perspective of post-invasion processes that has been substantiated in terrestrial systems but is often lacking in marine systems. Read moreRead less
Mapping the novice-expert continuum in composing and performing. The project explores those strategies that develop human potential across the novice-expert continuum; foster expert thought and practice; and encourage and manage innovation. Benefits include the generation of new knowledge that will impact on music learning theory and practice internationally.
Genealogy and Topology: A Constellational Comparison of Nietzsche and Heidegger. This research is fundamental in character addressing basic questions about the nature and history of philosophy. It will have direct academic benefits in advancing disciplinary knowledge, in enhancing the reputation of Australian philosophy in Germany and internationally, and in promoting contact between Australian and German philosophers, but is also likely to have longer term benefits in furthering our understandi ....Genealogy and Topology: A Constellational Comparison of Nietzsche and Heidegger. This research is fundamental in character addressing basic questions about the nature and history of philosophy. It will have direct academic benefits in advancing disciplinary knowledge, in enhancing the reputation of Australian philosophy in Germany and internationally, and in promoting contact between Australian and German philosophers, but is also likely to have longer term benefits in furthering our understanding of the nature of concepts, and of conceptual creativity.Read moreRead less
The Future of Oceans Governance in Polar Areas. Australia has a compelling national interest in maintaining its sovereignty and security in the Antarctic. Australian government goals include maintaining the Antarctic Treaty System (ATS); enhancing Australia's influence within the system; protecting the Antarctic environment; understanding the role of Antarctica in the global climate system; and undertaking scientific work of practical, economic and national significance. This project directly ad ....The Future of Oceans Governance in Polar Areas. Australia has a compelling national interest in maintaining its sovereignty and security in the Antarctic. Australian government goals include maintaining the Antarctic Treaty System (ATS); enhancing Australia's influence within the system; protecting the Antarctic environment; understanding the role of Antarctica in the global climate system; and undertaking scientific work of practical, economic and national significance. This project directly addresses national research priorities through analysis of oceans governance issues that centre on Australian interests. This project will also contribute to national benefit by focusing on issues central to the International Polar Year.Read moreRead less