Understanding The Regulation Of Cell Polarity In Development And Cancer
Funder
National Health and Medical Research Council
Funding Amount
$428,602.00
Summary
Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have now shown that the gene Scribble, a key regulator of cell orientation, may keep tumour development in check. In this proposal, we will examine how disruption of Scribble and associated molecules affects normal development and promotes cancer using a combination of tissue culture studies and a newly established mouse model. These studies may provide novel targets for therapeutic intervention in cancer.
Vestibulo-ocular Reflex Physiology, Pathology And Diagnosis.
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
A sensation of movement from the inner ear is used to stabilise vision during head movements. Without it, every time you walk, run, or drive on a bumpy road, the world would appear to bounce. It can be debilitating when this sense doesn't work due to various diseases. This research examines what causes these disorders and how the brain responds to help recovery. A diagnostic technique, that we will develop for wide clinical use, will be used to assess and identify treatments.
Using Good Measurement Principles To Examine Musculoskeletal Disease And Improve The Evaluation Of New Diagnostic Tests
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
This proposal will apply good measurement principles to 2 important but under-resourced areas: 1) To examine risk factors for musculoskeletal disease (particularly osteoarthritis or “wear and tear” arthritis) and to determine how changes in these risk factors in our community will affect the burden of disease, thus identifying new targets for disease prevention. 2) To improve our ability to evaluate how well new diagnostic tests function when introduced into our healthcare system.