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Relaxin-3 Systems In Brain: Neurophysiology And Behaviour
Funder
National Health and Medical Research Council
Funding Amount
$287,321.00
Summary
The project aim is to better understand the function of a newly-discovered signalling molecule in the mammalian brain, know as relaxin-3. Recent research suggests that this chemical is vital for normal animal behaviour, such as arousal, stress, and learning and memory processes. This project will thoroughly characterise how this chemical modulates activity of brain regions that subserve behaviour in rats. This should reveal clinical implications of relaxin-3 in human behavioural disorders.
Mechanisms Of Head And Neck Cancer Progression Role Of Matrix Metallopreinase (MMP-2) Using In Vitro And In Vivo Anima
Funder
National Health and Medical Research Council
Funding Amount
$218,668.00
Summary
This proposal will assist in improving human health, quality of life and patient lifespan. Head and Neck cancer is of high prevalence in Australia and China. Cancer patients, often with metastasis to adjacent and distant organs, including bone at late stages of the disease, suffer from pain, facial nerve paralysis, recurrence and frequently die under very distressing circumstances. This proposal intends to elucidate the molecular mechanism of Head and Neck cancer and help come up with better tre ....This proposal will assist in improving human health, quality of life and patient lifespan. Head and Neck cancer is of high prevalence in Australia and China. Cancer patients, often with metastasis to adjacent and distant organs, including bone at late stages of the disease, suffer from pain, facial nerve paralysis, recurrence and frequently die under very distressing circumstances. This proposal intends to elucidate the molecular mechanism of Head and Neck cancer and help come up with better treatments against cancers including providing a new target for cancer gene therapy.Read moreRead less
An Investigation Of The Role Of The Pre-frontal Cortex In Cognitive Ageing And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$291,629.00
Summary
This project will investigate the role of the pre-frontal cortex in cognitive ageing and dementia. New neuroimaging techniques will be used to precisely measure this cerebral structure in a large ageing cohort The new brain measures will be used to identify risk and protective factors of cognitive ageing and dementia. This project is highly significant because it will contribute to the identification of at risk individuals and guide future intervention and clinical studies.
Family Mental Health And Pregnancy Outcomes: A Program Of Population Research.
Funder
National Health and Medical Research Council
Funding Amount
$292,639.00
Summary
Mental illness is a big disease burden of the population. Mental health problems may contribute to poor pregnancy outcomes. And pregnancy and birth may also increase the severity of parents’ mental disorder. This study is to investigate that how many women with history of family mental illness give birth in NSW and what is the relationship between mental health and pregnancy and birth. The study aims to provide information to improve mother and baby’s health.
Improving The Bioavailability Of Peptide-based Therapeutics For The Treatment Of Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$341,123.00
Summary
Many diseases are controlled at the molecular level by proteins and their interactions with other proteins. Harmonin is a key protein in Usher syndrome, the most common form of deaf-blindness in humans, and harmonin has similarities to some proteins involved in Alzheimer’s disease. We seek to understand how harmonin works. The findings of this study may lead to new treatments for deaf-blindness and Alzheimer’s disease.