Impact of evaluation-based funding on the content of scientific research. Evidence suggests that evaluation-based funding mechanisms trigger adaptive behaviour in scientists, leading to unintended changes in knowledge production. However, there is no conclusive evidence about when (under what circumstances), how (by what processes) and with what effects researchers adapt to these mechanisms. This study aims to answer these crucial questions. To overcome the methodological weaknesses of earlier s ....Impact of evaluation-based funding on the content of scientific research. Evidence suggests that evaluation-based funding mechanisms trigger adaptive behaviour in scientists, leading to unintended changes in knowledge production. However, there is no conclusive evidence about when (under what circumstances), how (by what processes) and with what effects researchers adapt to these mechanisms. This study aims to answer these crucial questions. To overcome the methodological weaknesses of earlier studies, a comparative investigation of several research fields and universities will be conducted, combining for the first time: qualitative interviews, ethnographic observations and bibliometric studies. It will enhance Australian research policy with a critical assessment of existing research funding models.Read moreRead less
Mathematical models of diseases with complex transmission routes. This project aims to model diseases that spread via a mixture of routes including food, water, the environment, and direct spread between individuals. Key diseases include: avian influenza, which causes massive disruption to the poultry industry; gastroenteritis, which costs Australia $1,250 million each year; and leptospirosis, which causes one million severe illnesses each year globally. This project will develop mathematical a ....Mathematical models of diseases with complex transmission routes. This project aims to model diseases that spread via a mixture of routes including food, water, the environment, and direct spread between individuals. Key diseases include: avian influenza, which causes massive disruption to the poultry industry; gastroenteritis, which costs Australia $1,250 million each year; and leptospirosis, which causes one million severe illnesses each year globally. This project will develop mathematical and statistical tools to better estimate risk, analyse outbreak data, and provide guidance for disease control. This research will improve policy and enhance our ability to respond to disease outbreaks.Read moreRead less
Learning clique potentials for high-order graphical models. This project aims to develop algorithms for computers to automatically learn about visual scenes and objects from images. Using our algorithms, computers will be able to find objects and describe scenes in single images or large image collections such as online photo albums.
Nano-reactors: Protein cages as reusable scaffolds for designer enzymes. This project aims to develop robust protein cages derived from the coats of viruses to contain heat-stable P450 enzymes, for use as specialised protein bio-catalysts in chemical industries. A valuable chemical precursor of renewable bio-plastics will be produced from seed oils by enzymes, reducing the use of fossil fuels. This synthetic biology approach combines biotechnology, nanotechnology and protein engineering to estab ....Nano-reactors: Protein cages as reusable scaffolds for designer enzymes. This project aims to develop robust protein cages derived from the coats of viruses to contain heat-stable P450 enzymes, for use as specialised protein bio-catalysts in chemical industries. A valuable chemical precursor of renewable bio-plastics will be produced from seed oils by enzymes, reducing the use of fossil fuels. This synthetic biology approach combines biotechnology, nanotechnology and protein engineering to establish a plant-based platform biotechnology for using enzymes as catalysts to make high-value molecules. The project aims to show how to engineer clean, sustainable chemistry in designer nano-environments. This should make synthetic processes more sustainable and enhance advanced chemical manufacturing in Australia.Read moreRead less
Characterisation of a novel disease immunity pathway in plants. This project aims to understand the mechanisms by which the novel signalling molecule, CAPE1, contributes to
plant immunity. Studies to date have confirmed that CAPE1 inhibits plant diseases but it is unknown how. This
project aims to provide a seminal advance to the field by elucidating how the peptide is generated, how it is
perceived by the plant and the processes by which peptide contributes to plant defence. The expected outcom ....Characterisation of a novel disease immunity pathway in plants. This project aims to understand the mechanisms by which the novel signalling molecule, CAPE1, contributes to
plant immunity. Studies to date have confirmed that CAPE1 inhibits plant diseases but it is unknown how. This
project aims to provide a seminal advance to the field by elucidating how the peptide is generated, how it is
perceived by the plant and the processes by which peptide contributes to plant defence. The expected outcomes
of this project will include a detailed characterisation of a novel plant defence pathway as well the education and
training of next generation of plant scientists. Achieving these outcomes would provide the basis for new
innovative disease management strategies through the manipulation of this novel pathway.Read moreRead less
Controlling the rate of transcription and translation of Rubisco transgenes effectively in higher-plant plastids. Genetic transformation of the circular genome of the plastids provides a containable means for modifying plant growth by manipulating photosynthesis. Although the transformation mechanism is precise, predicting the level of foreign gene expression is difficult because the amounts of messenger RNA and protein produced by foreign genes in plastids varies widely, even when the protein a ....Controlling the rate of transcription and translation of Rubisco transgenes effectively in higher-plant plastids. Genetic transformation of the circular genome of the plastids provides a containable means for modifying plant growth by manipulating photosynthesis. Although the transformation mechanism is precise, predicting the level of foreign gene expression is difficult because the amounts of messenger RNA and protein produced by foreign genes in plastids varies widely, even when the protein assembles without difficulty. This project will devise strategies for controlling this variability that will facilitate attempts to exploit plastid transformation for transplanting better versions of the photosynthetic CO2-fixing enzyme, Rubisco, into plants to improve their growth efficiency in terms of water, fertiliser and light use.Read moreRead less
Practical strategies for engineering the CO2-fixing enzyme, Rubisco, whose subunits are encoded in different subcellular compartments. My recent replacement of the plant CO2-fixing enzyme, Rubisco, with a less efficient bacterial version, with a single type of subunit encoded by a single gene, demonstrated the feasibility of replacing Rubisco. This encourages ongoing attempts to replace plant Rubisco with more efficient versions that would allow the plants to grow with less water, fertiliser or ....Practical strategies for engineering the CO2-fixing enzyme, Rubisco, whose subunits are encoded in different subcellular compartments. My recent replacement of the plant CO2-fixing enzyme, Rubisco, with a less efficient bacterial version, with a single type of subunit encoded by a single gene, demonstrated the feasibility of replacing Rubisco. This encourages ongoing attempts to replace plant Rubisco with more efficient versions that would allow the plants to grow with less water, fertiliser or light. The most efficient Rubiscos are more complex, with two different types of subunits which, in plants, are encoded in different subcellular compartments (nucleus and plastid). This proposal addresses the challenges associated with complementary engineering both genomes to substitute foreign Rubiscos into higher-plant chloroplasts.Read moreRead less
Indigenous Australians and alcohol control: The impact of hotel ownership on harm reduction and social and economic development. This project investigates Indigenous social enterprise that intersects with the alcohol industry. Findings will benefit the Indigenous governing bodies of licensed premises and their communities, health and liquor regulation authorities and the country as a whole. The research addresses policy uncertainty surrounding Indigenous ownership of licensed premises and whethe ....Indigenous Australians and alcohol control: The impact of hotel ownership on harm reduction and social and economic development. This project investigates Indigenous social enterprise that intersects with the alcohol industry. Findings will benefit the Indigenous governing bodies of licensed premises and their communities, health and liquor regulation authorities and the country as a whole. The research addresses policy uncertainty surrounding Indigenous ownership of licensed premises and whether this achieves anticipated economic and social goals and reduces alcohol-related problems. Harm minimisation is an object of liquor licensing acts in most jurisdictions in Australia. Indigenous-owned licensed premises are well-placed to implement responsible alcohol service and promote harm minimisation in keeping with Australian best practice.Read moreRead less
When Your Face is Your ID: Public Responses to Automated Facial Recognition. This project would explore public attitudes toward the use of facial recognition technology in public and commercial spaces, schools, and workplaces with a national survey, focus group interviews, and four case studies. The project aims to generate new knowledge about public attitudes through a multi-method interdisciplinary approach that anticipates the future of the technology by studying its use in China. Expected ou ....When Your Face is Your ID: Public Responses to Automated Facial Recognition. This project would explore public attitudes toward the use of facial recognition technology in public and commercial spaces, schools, and workplaces with a national survey, focus group interviews, and four case studies. The project aims to generate new knowledge about public attitudes through a multi-method interdisciplinary approach that anticipates the future of the technology by studying its use in China. Expected outcomes include public reports on the survey and case studies, seven academic journal articles, and a book. The research would provide significant benefits by contributing new knowledge about how to implement the technology in accordance with Australian commitments to civil rights, ethics and democratic values.
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Active Sound Control and Noise Cancellation over Space. This project aims to address the critical issues for creating acoustic quiet zones in a noisy environment. It will provide novel signal processing theory for further development of active noise cancellation techniques over spatial regions. New technologies developed from this project are expected to underpin the future development of acoustic signal processing research and will have a broad range of applications such as reduction of noise i ....Active Sound Control and Noise Cancellation over Space. This project aims to address the critical issues for creating acoustic quiet zones in a noisy environment. It will provide novel signal processing theory for further development of active noise cancellation techniques over spatial regions. New technologies developed from this project are expected to underpin the future development of acoustic signal processing research and will have a broad range of applications such as reduction of noise inside cars, creation of individual quiet zones in passenger planes and mitigation of acoustic noise made by industrial plants to neighbouring suburbs. The outcomes from this proposal will also have economic importance as it can reduce the health risk posed to people working or living in noisy environments.Read moreRead less