Development Of Novel Antibacterial Compounds From Subtilosin A
Funder
National Health and Medical Research Council
Funding Amount
$490,724.00
Summary
We aim to overcome a problem that is not being addressed by pharmaceutical companies- i.e., there is an urgent need to develop new classes of antibacterial drugs because of the increasing prevalence of drug resistant bacteria. We will combine genetics, structural biology and chemistry to develop a new class of anti-bacterial drug based on a naturally occurring microbial molecule that is novel in structure and very stable- attributes that make it very different to existing therapeutic approaches.
Population Prevalence And Environmental-genetic Predictors Of Food Allergy In An Infant Cohort
Funder
National Health and Medical Research Council
Funding Amount
$551,642.00
Summary
This study will measure which children are at greatest risk of food allergy. We plan to recruit 5000 children to test for food allergies, as well as asking a range of questions on different lifestyle factors such as diet and history of allergies . If positive, participants will be invited to a hospital clinic for tests and treatment. This will allow us to describe the epidemiology of food allergy, and assist the development of better services for those with food allergy in the community.
�Percent Daily Intake� Versus �Equivalent Walking Time�: Making Sense Of The Kilojoules On Food And Drink Labels
Funder
National Health and Medical Research Council
Funding Amount
$108,350.00
Summary
We have already established through a series of eight qualitative focus groups plus a pilot survey using a convenience sample that the Equivalent Walking Time (EWT) food label is considered more informative, useful, and difficult to ignore than other labelling systems. As such we now seek to test the EWT against other labelling systems in a more objective and robust fashion, using a much larger, representative sample.
Physical Activity Restores Energy Homeostasis In Obesity Through Hypothalamic Neurogenesis
Funder
National Health and Medical Research Council
Funding Amount
$334,053.00
Summary
The sensing of blood-borne signals by the brain is an important event in regulating appetite and energy expenditure. This sensing is blunted in obesity and contributes to over-eating. The aim of this research is to determine whether the sensing of these blood-borne signals can be restored in obesity by creating new cells in the key appetite controlling centres of the brain. The outcomes of this research will lead to a better understanding of how feeding behaviour can be modified to treat obesity ....The sensing of blood-borne signals by the brain is an important event in regulating appetite and energy expenditure. This sensing is blunted in obesity and contributes to over-eating. The aim of this research is to determine whether the sensing of these blood-borne signals can be restored in obesity by creating new cells in the key appetite controlling centres of the brain. The outcomes of this research will lead to a better understanding of how feeding behaviour can be modified to treat obesity.Read moreRead less
A Multi-level Study Of Socioeconomic Status And Healthy Food Purchasing Behaviour
Funder
National Health and Medical Research Council
Funding Amount
$173,492.00
Summary
Socioeconomically disadvantaged groups have the highest rates of death and ill-health for diet-related diseases (eg. coronary heart disease, some cancers). Our understanding of the dietary practices which may contribute to these outcomes, however, is limited. This project focuses on this issue by examining the relationship between socioeconomic status and food purchasing behaviour. Studies investigating this relationship have found that disadvantaged social groups are least likely to purchase fo ....Socioeconomically disadvantaged groups have the highest rates of death and ill-health for diet-related diseases (eg. coronary heart disease, some cancers). Our understanding of the dietary practices which may contribute to these outcomes, however, is limited. This project focuses on this issue by examining the relationship between socioeconomic status and food purchasing behaviour. Studies investigating this relationship have found that disadvantaged social groups are least likely to purchase foods which are important for long-term health. The reasons for this association, however, remain unclear. Research into the general determinants of food purchasing behaviour shows that food choices are influenced by the intra-personal characteristics of individuals (eg. knowledge and beliefs), interactions between individuals sharing the same context (eg. relations between parents and children), economic and material factors (eg. income, access to a car) and features of the wider physical environment (eg. availability of healthy food and public transport). What is clear from this evidence, is that food choice is influenced by factors which operate at multiple levels. This project aims to collect data simultaneously from each level, and determine whether (and to what extent) factors operating at each level differentially influence the food purchasing behaviours of socioeconomic groups. This study (i) will contribute to our understanding of why socioeconomic groups differ in their health status, (ii) is consistent with the goals and recommendations of numerous government reports, each of which calls for a a reduction in health inequalities, (iii) represents a methodological advance on previous research, and (iv) will generate the information necessary to develop innovative and appropriately targeted health promotion and health education campaigns.Read moreRead less
It is clear that the rate of obesity is increasing dramatically. Better therapeutic strategies are required to treat this debilitating disease. In this study we will determine the effects of sugary drinks on the amount of food eaten and subsequent changes in weight gain. By understanding how sugary drinks affect rates of weight gain we will be able to formulate better strategies to combat obesity.
Diet-induced obesity is the foremost health concern in today�s society and causes many metabolic problems that lead to type diabetes and cardiovascular disease. This grant identifies ghrelin resistance, as a novel metabolic adaptation during obesity. Ghrelin is a hormone that normally stimulates food intake and body weight gain, however during obesity ghrelin does not stimulate food intake. Artificial induction of ghrelin resistance will restrict the development of diet _induced obesity.