Discovery and characterisation of novel lanthipeptide biopreservatives. The aim of this project is to advance fundamental knowledge of microbial metabolism and provide natural anti-microbial molecules to the Australian food industry. A quarter of the world’s food supply is lost because of microbiological spoilage. Some chemical preservatives have been developed to combat food spoilage organisms, however their chronic impact on human health is the subject of debate. Consumer demand for safe and n ....Discovery and characterisation of novel lanthipeptide biopreservatives. The aim of this project is to advance fundamental knowledge of microbial metabolism and provide natural anti-microbial molecules to the Australian food industry. A quarter of the world’s food supply is lost because of microbiological spoilage. Some chemical preservatives have been developed to combat food spoilage organisms, however their chronic impact on human health is the subject of debate. Consumer demand for safe and natural alternatives is growing. Paradoxically, microbially-produced bioactive peptides may be the key to combating food spoilage organisms and food-borne pathogens. To this end, the project intends to develop an innovative strategy for the discovery, biosynthesis and characterisation of novel anti-microbial lanthipeptides.Read moreRead less
Portable biosensor for rapid detection of viral contamination in food . The objective of this project is to create a miniaturised and cost-effective electrochemical biosensor device that can detect multiple pathogens, simultaneously, even at very low level of concentrations. This device will be crucial for rapidly detect pathogen contamination in food and water to monitor their safety and quality, particularly beneficial in an outbreak or natural disaster for testing these resources. In additio ....Portable biosensor for rapid detection of viral contamination in food . The objective of this project is to create a miniaturised and cost-effective electrochemical biosensor device that can detect multiple pathogens, simultaneously, even at very low level of concentrations. This device will be crucial for rapidly detect pathogen contamination in food and water to monitor their safety and quality, particularly beneficial in an outbreak or natural disaster for testing these resources. In addition to food and water, the successful development of this versatile cost-effective sensor will benefit a wide range of companies such as pharmaceuticals, medical device manufacturing and farms for controlling product quality where detection of life threatening pathogens is pivotal to prevent risk for consumers.Read moreRead less
Improved biosecurity through the engineering of microbial ecosystems. This project aims to provide data and understanding that will help develop predictive models for changes in the distribution of drug-resistant bacteria, and surveillance and response programs for key biosecurity threats. Microorganisms, including commensals and pathogens, can live in complex communities in a range of environments including animal hosts. It is now known that these communities (known as microbiomes) can exert a ....Improved biosecurity through the engineering of microbial ecosystems. This project aims to provide data and understanding that will help develop predictive models for changes in the distribution of drug-resistant bacteria, and surveillance and response programs for key biosecurity threats. Microorganisms, including commensals and pathogens, can live in complex communities in a range of environments including animal hosts. It is now known that these communities (known as microbiomes) can exert a profound effect on animal health. This project seeks to understand where antimicrobial resistance genes reside in pig gut microbiotia and how they move between members of this complex microbial community, and to provide information on how probiotics may be used to reduce dependence on antibiotics.Read moreRead less
Managing uncertainty in RFID traceability networks. Australia suffers 5.4 million cases of food-borne illness every year, which leads to 2.1 million days of lost work, 1.2 million people visiting a doctor, and 120 deaths annually. This has revealed the urgent need for improved ways of locating and recalling problematic products that have been released into the community. The project will develop novel techniques driven by Radio Frequency Identification (RFID) technology for improving the effici ....Managing uncertainty in RFID traceability networks. Australia suffers 5.4 million cases of food-borne illness every year, which leads to 2.1 million days of lost work, 1.2 million people visiting a doctor, and 120 deaths annually. This has revealed the urgent need for improved ways of locating and recalling problematic products that have been released into the community. The project will develop novel techniques driven by Radio Frequency Identification (RFID) technology for improving the efficiency and accuracy of product tracking in distribution networks. This project will place Australia at the forefront of RFID research. It will also be an excellent vehicle for educating young researchers and engineers in Australia.Read moreRead less
New fertiliser technologies for sustained food security. This project aims to provide fundamental research to develop next-generation fertiliser products that will improve nitrogen use efficiency, and reduce nitrogen losses in food production systems. It will achieve this goal through a multidisciplinary approach combining experts in synthetic and free radical chemistry, chemical engineering and soil science, with a strong commitment from a fertiliser industry partner. Society is facing the tri ....New fertiliser technologies for sustained food security. This project aims to provide fundamental research to develop next-generation fertiliser products that will improve nitrogen use efficiency, and reduce nitrogen losses in food production systems. It will achieve this goal through a multidisciplinary approach combining experts in synthetic and free radical chemistry, chemical engineering and soil science, with a strong commitment from a fertiliser industry partner. Society is facing the triple challenges of food security, environmental degradation and climate change The availability of new, highly-efficient fertilisers is critical for addressing these challenges, and for the competitive advantage of the Australian fertiliser industry.Read moreRead less
Electrochemical sensors as early alert screening tools for water quality assessment. This project will impact on water safety assessment and provide better management tools for water pollutant control. It will address a real need to develop on-line detection technologies for application in the water industry and will demonstrate the potential broad applicability of this technology to a wide range of analytes of concern.
Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors w ....Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors will be used to devise a simple portable colorimetric test that can be performed in the vineyard or the winery. The ability to rapidly determine the level of grape contamination with phenolic glucosides would give Australian wine growers and wine makers a powerful tool to mitigate the effects of bushfires.Read moreRead less
Real-time phylogenetics for food-borne outbreak surveillance. The project aims to introduce, for the first time, real-time evolutionary analysis of agricultural pathogens so that outbreaks affecting crops and the food supply can be managed precisely and rapidly. An expert team will implement a large-scale data analytics framework in user-friendly software that integrates Australian infectious disease genomics data with global data. Underpinning this work are new theory and algorithms that apply ....Real-time phylogenetics for food-borne outbreak surveillance. The project aims to introduce, for the first time, real-time evolutionary analysis of agricultural pathogens so that outbreaks affecting crops and the food supply can be managed precisely and rapidly. An expert team will implement a large-scale data analytics framework in user-friendly software that integrates Australian infectious disease genomics data with global data. Underpinning this work are new theory and algorithms that apply Sequential Monte Carlo to update phylogenetic analyses continuously as new data arrives. Expected outcomes include new knowledge of statistical algorithms for evolutionary analysis, relevant to biological disciplines beyond infectious disease; and enhanced capacity for infectious disease analysis. Read moreRead less
Identifying and controlling the source of Campylobacter and Salmonella in Australia. This project will identify the source of foodborne illnesses due to Salmonella and Campylobacter in order to inform food regulatory policy. The ultimate aim is to reduce the amount of foodborne disease in Australia.
Plant cyclotides as novel sustainable tools for crop protection . This project between the University of Queensland and Syngenta, a top-tier agricultural biotech company, aims at developing new crop protection technologies based on peptides. Insecticides are essential to meet the 60% increase in food production goal set by the UN but long-term exposure to traditional insecticides can harm beneficial pollinating insect populations. Expected outcomes include an exciting new insecticide technology ....Plant cyclotides as novel sustainable tools for crop protection . This project between the University of Queensland and Syngenta, a top-tier agricultural biotech company, aims at developing new crop protection technologies based on peptides. Insecticides are essential to meet the 60% increase in food production goal set by the UN but long-term exposure to traditional insecticides can harm beneficial pollinating insect populations. Expected outcomes include an exciting new insecticide technology based on natural plant defense peptides, the cyclotides, which has potential to revolutionise crop protection, leading to safer products for the environment. Benefits from the technology include a reduction in toxic insecticide residues, precision targetted applications and agrichemicals that degrade without trace.Read moreRead less