Food And Water For Life: Co-creation And Evaluation Of Sustainable Innovations To Strengthen Food And Water Security
Funder
National Health and Medical Research Council
Funding Amount
$1,169,419.00
Summary
Aboriginal and Torres Strait Islander peoples suffer a disproportionate burden of non-communicable diseases. Poor diets, exacerbated by low quality water supplies, are one of the biggest contributors to this. Through our existing long-standing partnership, his project will establish a framework and use regulatory analysis to support the Aboriginal community in Walgett to develop a transformative community-led food and water security action plan to improve the long-term health and well-being.
Exploiting Messenger RNA Export As A Novel Therapeutic Strategy To Treat Cancer
Funder
National Health and Medical Research Council
Funding Amount
$948,098.00
Summary
Novel therapies for cancers represent an area of unmet clinical need. We have identified a new biological pathway implicated in cancer, namely selective mRNA export. Compounds inhibiting other steps of the gene expression pathway are promising therapeutic candidates for cancer, yet mRNA export inhibitors do not exist. We propose to develop first-in-class inhibitors of mRNA export that selectively target transcriptionally addicted cancers with dysregulated RNA processing.
Pathways That Regulate Nuclear Export Of Circular RNA
Funder
National Health and Medical Research Council
Funding Amount
$933,327.00
Summary
An emerging and unusual class of RNA molecules, circular RNAs (circRNAs), is widespread and plays important roles in cancer initiation and progression. However, the pathways responsible for nuclear export of circRNAs are unknown. We propose here to systematically determine how circRNAs are exported from the nucleus and characterise the effect of modulating circRNA export pathways in cancer. This will enable us to determine whether circRNAs can function as a biomarker of patient response.